Need to be more specific here when speaking in terms of less suppression, impact on fertility let alone dopamine!
Again this is thrown out the window with daily prop if you are one who pushes your peak TT/FT and more importantly trough up too high.
Many jumping on the TP bandwagon especially those idiots with that more T is better mentality are running around with absurdly high peak FT levels let alone high/absurdly high troughs!
This will result in a strong suppression of the hpta.
Again look up the PK/half-life TP vs oral TU vs Natesto!
Oral TU is dosed twice-daily (2 peaks/troughs).
There is still a strong suppression of the hpta.
When using daily short-acting TP the T levels achieved peak vs trough let alone the time period over those 24 hrs T levels are elevated whether mid-range/high/absurdly high will still result in a strong suppression of the hpta.
Again many are running way too high a peak land more importantly trough FT level when using a daily TP protocol!
You have guys injecting 25-30 mg TP daily which is a whopping f**king dose!
If anything the main advantage when using TP would be the daily peak/trough!
This may have a positive impact on energy, mood, libido and sleep for some.
The OP of this thread is one of the few that is using a low daily dose of TP without pushing his peak absurdly high let alone trough FT too high!
Keep in mind he had his first set of labs done 12 hrs post-injection so he clearly missed testing at peak!
Howdy, Basic question--I tried the search feature but could not find definitive information on the following. The specific question: Is there a dosing of Testosterone Enanthate (in mg per week) below which you can expect to preserve what is left of natural testosterone production? Does the...
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Well only 8mg of straight Prop peaked me at 1200 TT ! since Tprop would quickly taper off question is how long after injection. TBH the blood levels are way overvalued by most in T community. most of the action happens at the receptor you can't measure that. i completely ignore all those...
www.excelmale.com
Again would tread lightly on how high you run your trough/steady-state FT level! This can easily backfire in the long-run for many especially when it comes to mood, libido and erectile function! Too high a FT level can be just as bad in many ways as having too low a FT level. Libido starts in...
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*dopamine circuits are powerfully regulated by androgens
*
androgens as potent modulators of prefrontal cortical operations and of closely related, functionally critical measures of prefrontal dopamine level or tone
*androgens dynamically control meso prefrontal dopamine systems and impact prefrontal states of hypo- and hyper-dopaminergia
*dopamine-dependent prefrontal operations appear to universally follow inverted U shaped functions
* androgens maintain a lifelong capacity to bidirectionally modulate prefrontal dopamine tone
*By targeting enzymes and signaling molecules associated with androgenic metabolites of testosterone (Fig 1), these studies more directly implicate androgens in modulating prefrontal function. They also show that both supranormal androgen stimulation and androgen deficiency negatively affects prefrontal operations (Fig 2A). This inverted U- shaped function is similar to that described for functional meso prefrontal dopamine settings (Cools R and D'Esposito M, 2011; Cools R et al.,2019; Floresco SB, 2013; Floresco SB and Magyar O, 2006)
*The data also demonstrate an inverted U-shaped function that describes these dopamine effects. According to this function, prefrontal dopamine levels— often referred to as prefrontal dopamine tone- that are either higher or lower than a functionally optimal set point are detrimental to behavior and circuit function (Fig 2B).
