Low Dose Nandrolone With TRT

[Nelson Vergel]

Nandrolone is increasingly being considered as an adjunct therapy in conjunction with testosterone replacement therapy (TRT) for men suffering from hypogonadism. This practice is particularly prevalent among those who experience joint pain. When administered in low doses alongside TRT, nandrolone may offer several potential benefits without the severity of side effects commonly associated with higher doses of anabolic steroids.

Benefits of Low Dose Nandrolone with TRT​

The integration of nandrolone into TRT regimens can result in a variety of improvements:

• Increased Muscle Mass and Strength: Nandrolone has a high anabolic to androgenic ratio, enhancing its muscle-building capacity compared to testosterone alone [1] [2].
• Enhanced Bone Density: The drug has been shown to positively affect bone density, which is crucial for the elderly or those at increased risk of osteoporosis [1] [4].
• Reduction in Joint Pain: Many users report significant relief from joint discomfort, which can be a substantial benefit for long-term quality of life [3].
• Faster Injury Recovery: Anabolic effects also include improved recovery times from injuries, making it a favored option in sports medicine and rehabilitation contexts [2].

How It Works​

Nandrolone differs from testosterone by its reduced conversion to dihydrotestosterone (DHT), which minimizes androgenic side effects such as hair loss and prostate enlargement. This characteristic also influences its preferable use in TRT, where the goal is to mitigate unwanted androgenic reactions while enhancing anabolic effects [3] [4].

Administration and Dosage​

In therapeutic settings, nandrolone is typically administered at a fraction of the dosage of testosterone. Studies have demonstrated effective use at half the dose of testosterone, which minimizes potential side effects while maintaining beneficial outcomes [3]. It is critical, however, to always use nandrolone in conjunction with testosterone to prevent issues like erectile dysfunction due to suppressed natural testosterone production [2] [3].

Potential Risks​

Despite its benefits, the use of nandrolone comes with risks that must be carefully managed:

• Side Effects: Users may experience headaches, acne, and fluid retention. Other serious concerns include changes in HDL cholesterol levels and increased blood pressure [2] [5] [6].
• Cardiovascular Risks: There is an ongoing debate regarding the impact of nandrolone on cardiovascular health, which should be a consideration in its administration [5].

Regulatory and Health Considerations​

Nandrolone is a controlled substance and should only be used under medical supervision. It is essential that a healthcare provider prescribe it because non-prescribed use can have detrimental effects on one's health [6]. This healthcare provider can then conduct routine monitoring through blood tests and health assessments.

The decision to add nandrolone to a TRT program should not be taken lightly. The long-term effects and safety of nandrolone use in conjunction with TRT are still under investigation. As with any medical treatment, a healthcare professional's guidance is indispensable.

Benefits of Low Dose Nandrolone with TRT​

The integration of nandrolone into TRT regimens can result in a variety of improvements:

• Increased Muscle Mass and Strength: Nandrolone has a high anabolic to androgenic ratio, enhancing its muscle-building capacity compared to testosterone alone [1] [2].
• Enhanced Bone Density: The drug has been shown to positively affect bone density, which is crucial for the elderly or those at increased risk of osteoporosis [1] [4].
• Reduction in Joint Pain: Many users report significant relief from joint discomfort, which can be a substantial benefit for long-term quality of life [3].
• Faster Injury Recovery: Anabolic effects also include improved recovery times from injuries, making it a favored option in sports medicine and rehabilitation contexts [2].

How It Works​

Nandrolone differs from testosterone by its reduced conversion to dihydrotestosterone (DHT), which minimizes androgenic side effects such as hair loss and prostate enlargement. This characteristic also influences its preferable use in TRT, where the goal is to mitigate unwanted androgenic reactions while enhancing anabolic effects [3] [4].

Administration and Dosage​

In therapeutic settings, nandrolone is typically administered at a fraction of the dosage of testosterone. Studies have demonstrated effective use at half the dose of testosterone, which minimizes potential side effects while maintaining beneficial outcomes [3]. It is critical, however, to always use nandrolone in conjunction with testosterone to prevent issues like erectile dysfunction due to suppressed natural testosterone production [2] [3].

Potential Risks​

Despite its benefits, the use of nandrolone comes with risks that must be carefully managed:

• Side Effects: Users may experience headaches, acne, and fluid retention. Other serious concerns include changes in HDL cholesterol levels and increased blood pressure [2] [5] [6].
• Cardiovascular Risks: There is an ongoing debate regarding the impact of nandrolone on cardiovascular health, which should be a consideration in its administration [5].

Regulatory and Health Considerations​

Nandrolone is a controlled substance and should only be used under medical supervision. Non-prescribed use can lead to serious health consequences, reinforcing the necessity for it to be prescribed by a healthcare provider who can conduct regular monitoring through blood tests and health assessments [6].

The decision to add nandrolone to a TRT program should not be taken lightly. The long-term effects and safety of nandrolone use in conjunction with TRT are still under investigation. As with any medical treatment, a healthcare professional's guidance is indispensable.

Citations​

1. Innovative Men's Health
2. Alpha Hormones
3. Regenx Health
4. PMC Article on Nandrolone
5. PMC Article on Cardiovascular Risks
6. Cleveland Clinic on Nandrolone

The careful application of low dose nandrolone in conjunction with TRT can be a valuable component of a comprehensive treatment strategy for specific patient groups, offering benefits that enhance both quality of life and physical functioning.

Forum Discussions:

folks on nandrolone what are some typical protocols for TRT​

Low dose nandrolone with low dose testosterone​

Nandrolone (Deca) Base TRT Trial​

nandrolone decanoate​

Is low dose nandrolone safe?​

Deca (nandrolone) for joint pain | Excel Male TRT Forum​

Nandrolone - What to expect - Hb/HCT, HDL, Muscle?​

Nandrolone (Deca Durabolin): Effect on Lab Tests


Nandrolone (Deca Durabolin): Effect on Lab Tests

​

 

[Nelson Vergel]

This slide show provides information on the clinical uses of FDA-approved anabolic-androgenic steroids (AAS), with a focus on Nelson Vergel's descriptions of their medical and therapeutic applications. Here's a summary of the content available in the file:

Slides also provided in the PDF file attached (ExcelMale members only)

1. Introduction and Disclaimer: States that the information provided does not constitute a recommendation and should be used at the discretion of the prescriber.
2. FDA-approved AAS for Human and Veterinary Use: Lists specific compounds approved for use and their formulations, including dosages and methods of administration.
3. Mechanisms and Effects of AAS:
   • Describes how AAS work at the cellular level to promote protein synthesis, increase appetite, and block fat storage.
   • Details both anabolic effects (such as increasing bone density and muscle mass) and androgenic effects (such as changes in sexual characteristics and increased aggression).
4. Side Effects of AAS: Discusses potential adverse effects, including cardiovascular, liver, and endocrine impacts, and suggests management strategies like phlebotomy for erythrocytosis or medications for managing gynecomastia.
5. Specific AAS Compounds:
   • Nandrolone: Includes background, clinical uses, and numerous study references supporting its use in treating conditions like anemia, osteoporosis, and muscle wasting.
   • Oxandrolone and Stanozolol: Provides detailed information on these compounds, including their use, dosages, and specific roles in medical treatments.
   • Oxymetholone (Anadrol): Discusses its properties, including its high potency and liver toxicity at certain dosages.
6. Testosterone Replacement Therapy (TRT) and Management of AAS Side Effects: Discusses the integration of TRT in managing the side effects of AAS use and outlines different therapeutic approaches for managing complications like decreased libido, hair loss, and liver enzyme increases.
7. Research and Studies: Provides citations and summaries of clinical studies and trials that examine the effectiveness of AAS in treating various medical conditions, highlighting the significant volume of research on nandrolone.

 

[Seagal]

Wasn't there recently a change in regulation for prescription of nandrolone?

 

[Nelson Vergel]

Wasn't there recently a change in regulation for prescription of nandrolone?

No. Only CA is making it very difficult for compounding pharmacies to ship injectables to that state.

 

[Nelson Vergel]

Dr. Robert Carlson, a board-certified general and cardiac surgeon with 15 years of experience in open-heart surgery, has shifted his focus over the past decade to patient optimization. He specializes in managing pain and enhancing energy and focus through the combined use of testosterone and nandrolone. Dr. Carlson has found this combination particularly effective in treating chronic joint and back pain, significantly improving patients' quality of life. He emphasizes regular monitoring of the liver and kidneys, noting that he has not observed any significant adverse effects on these organs with this treatment regimen. The protocol typically involves biweekly injections of both hormones, initially at higher doses, which are reduced after the first month. Dr. Carlson maintains a balanced ratio of these hormones to avoid side effects such as erectile dysfunction, underscoring the safety and efficacy of nandrolone when used appropriately.

 

[Nelson Vergel]

Formatted Transcript

Nelson Vergel: Hello, everyone. Nelson Vergel here from ExcelMale.com and DiscountedLabs.com. I’m joined by my good friend, Dr. Rand McClain. It’s been years since we did a video together, though you can find our past discussions on the ExcelMale YouTube channel. Dr. McClain, thanks for joining us. Many of our viewers are eager to hear from you about the latest advancements in hormone replacement for both men and women. But first, tell us what you’ve been up to. I hear you’ve opened a new clinic and have a book coming out. Fill us in.

Dr. Rand McClain: Thanks, Nelson. We’ve been busy! We recently opened a new clinic in Houston, located in The Woodlands, with Dr. Todd serving as the medical director. It officially opened at the beginning of August. So, for those who want an in-person visit, there’s now another option, though we continue to offer telemedicine across the U.S. and beyond.

Also, I finally completed my book, which has been quite an undertaking. It’s surreal to hold a copy in my hands after all the effort. You know how demanding the book-writing process can be! This one is called Cheating Death: The New Science of Living Longer and Better, and it’s available for pre-sale on Amazon.

Nelson: That’s amazing. I’m sure many of our viewers will want to check it out. Writing a book is no small feat, so congratulations. What are some of the key topics covered?

Dr. McClain: Thank you! The book is packed with information aimed at optimizing health and longevity. I wanted to share everything I’ve learned over the years, especially the things that often aren’t part of mainstream medical practice—which tends to be more “paint-by-numbers” healthcare. There’s so much patients don’t hear about unless they do their own research.

Nelson: That’s true. The healthcare landscape is changing, and consumers are becoming more empowered. Access to telehealth, blood tests without doctor visits, and shipped medications has improved tremendously in the past decade.

Dr. McClain: Exactly. People now have more opportunities to take control of their health. And that’s part of what I focus on—informing patients so they can advocate for themselves.

Nelson: Let’s talk about treatments that might not be well-known, like nandrolone. I’m obviously biased since I wrote about it in my first book. What’s your take on its medical use?

Dr. McClain: Nandrolone is a fantastic option with fewer androgenic side effects and minimal estrogen conversion. It’s especially useful for muscle mass preservation, which is why I prescribe it for patients with wasting disorders or those needing extra weight gain. It's affordable and effective, making it a great tool in our arsenal.

Nelson: Yes, and it’s approved for use. It’s good to see places like Baylor College of Medicine conducting studies on it for joint healing and pain management.

Dr. McClain: Absolutely. Baylor’s research is promising. Nandrolone’s use in lower doses for pain management has been effective, especially for patients who need alternatives to NSAIDs due to potential kidney and heart issues.

Nelson: Let’s move on to peptides like ibutamoren. Have you used it in your practice?

Dr. McClain: Yes, ibutamoren (MK-677) is one of the most effective growth hormone secretagogues. It’s easy to administer as an oral capsule, leading to significant IGF-1 increases. However, it can cause water retention and intense hunger. I’ve seen amazing results in patients, but dosing needs to be individualized.

Nelson: I’ve experienced that hunger firsthand—it’s intense! Lower doses or alternate-day use can help manage it.

Dr. McClain: Exactly. Starting with a lower dose like 12.5 mg and monitoring results can make a big difference. The appetite stimulation can be beneficial for those needing to gain weight, such as in cancer cachexia cases.

Nelson: That’s an interesting theory—ibutamoren combined with chemotherapy to support weight maintenance. It’s something oncologists should explore.

Dr. McClain: Definitely. More research could unlock its full potential.

Nelson: What about sexual function? Trimix and other compounded options seem promising.

Dr. McClain: Trimix is effective, especially when PDE5 inhibitors aren’t tolerated. It’s a reliable treatment for ED, but priapism is a risk, so it needs to be used under medical supervision. Injecting can sound daunting, but patients find it manageable after proper training.

Nelson: True. For some, PDE5 inhibitors cause side effects like headaches and back pain. Trimix is a game-changer for them.

Dr. McClain: Absolutely. It’s a great alternative when other options fail. Interestingly, studies have shown that PDE5 inhibitors can also reduce all-cause mortality after a heart attack.

Nelson: Yes, that’s a lesser-known benefit. Thanks for sharing that.

Dr. McClain: My pleasure. We could talk about this forever! For more information, visit our website at PSRMed.com. We’re expanding locations to make these treatments more accessible.

Nelson: Thanks, Dr. McClain. We’ll include the links in the video description. Remember to subscribe to the ExcelMale channel for more informative videos. Dr. McClain, it’s been great, and we’ll do this again soon.

Dr. McClain: Anytime, Nelson. It’s always a pleasure. Take care!

Nelson: You too—live long and prosper!