//minus the libido which is expected with a non functioning ER.//
Why did the case study of the man born with estrogen insensitivity have normal sexual function, including nocturnal erections and no ED/libido issues? Libido/ED is much deeper than just a single hormone.
With the new data emerging from PFS studies, you cannot rule out nocebo effect, considering placebo group (those who didnt take finasteride) reported a laundry list of sexual sides despite them getting sugar pills. There is no solid human data that finasteride does anything to receptors at all, its a theory, but there is scant data to back this up. People have recovered from PFS, that shows you that it's not permanent at all but they had to put in work to change their mind/body/gut. As for estrogen insensitivity, that has even fewer data to support it other than a few anecdotal accounts. We just can't make up stuff in medicine, there needs to be data behind it, even the supposed data and theory from moderators on PFS forums is lacking credibility, although their efforts were quite good. I also find it interesting that older men with BPH who take Finasteride at 5mg/day report less sexual sides than 20-30's men who take 1mg per day, the paradox of PFS continues...
//However, there's men who have not recovered and tried large amounts of T & DHT with no response and even got worse.//
Because its not black and white, there are guys with high T that have libido/ed issues, there are guys with low T that have no issues with libido. When my T was low, I could get rock hard and had a great libido and great mood, we know that hormones are important, but they are not the end all be all with the human psyche, we barely know anything about mental health, many theories, nothing solid.
//Lol and lastly, THERE IS NO EVIDENCE.//
You could be the first person this happened to in medical literature, but you must prove it first in which you are refusing to do, the pharmacology behind Arimidex does not support this and this is a heavily studied drug and we have had millions of patients take tremendously high doses of this medication for long periods of time, DATA would be somewhere, think of all the breast cancer women who take this medication for 7-10 years @ 1mg a day, we have a large sample size, we have absolutely ZERO evidence this happens. If we need more evidence for this problem, you really should step up for the sake of science. The easiest way to do this would be to come off TRT and get your baseline levels back, if your E2 skyrockets, congratulations, your E2 is skyrocketing because its not getting used by receptors.
Also, I've noticed a trend with you, your symptoms seem to come and go, one minute you are having anxiety depression, penile shrinkage etc, next minute your not. I cannot keep up with your symptom list anymore to establish a baseline.
Also, I've had joint popping with low E2, in range E2, and high E2, I don't see the correlation with the two. My wife has joint popping as well, and she's never taken an AI and her estrogen levels are within range. I don't see how half these problems have to do with insensitivity to estrogen. Anyways, I am getting burned out on this thread and it doesn't seem like we are getting any other contributers, so I am done here and unsubscribing.
You either have this problem or you don't. You have not been diagnosed with this problem other than a self-diagnosis, you cannot be 100% sure you are insensitive to estrogen, so its possible E2 is being used properly in your body. You can either let this defeat you or define you. Start fixing your body, the body always wants to return to homeostasis and has been shown to heal itself. I am 100% certain you can fix yourself but you HAVE to believe and you may have to make some drastic changes to your lifestyle.
I don't know why the case study with the man with EIS still had sexual function. His is congenital, his body's may have adapted differently. I still have sexual function, but it's ED and nothing like I had before. I still get nocturnal erections. but they're extremely weak and nothing like before. Remember, this guy could have nocturnal erections but still be weak and not full, but he doesn't know better, so he is reporting that he has them.
You need to stop looking at 1 single aspect to back up your point. it's not just libido. These guys use TRT and even use large doses and still have no libido, muscle wastage, penile shrinkage and tissue loss, facial boneloss, anhedonia, etc. It clearly shows androgen insensitivity. This is present in way too many men. And for the guys who recover, look at their initial symptoms, NONE had tissue loss. They just had ED, anxiety, low energy. Clearly hypogonadism or hypothyroidism, not PFS. You cannot lump these guys together as a whole. You can do your own research it's all there for you to see.
Ive noticed a trend with you too. You tend to give me a symptoms I never said I had. I never ever said I had shrinkage. Please review my initial posts. My symptoms are still the same, except slightly worse. Also, ever here of a good day and bad day? Yeah im depressed and have anxiety but I have a life, a girlfriend, family and responsibilities. Some days I feel Ok mentally, still depressed but trying to keep my mind off of it.
Once again everyone is different. Some people only have joint popping with low E2. Just because you have it with both, doesn't mean that's the case with everyone. I really hope you don't carry this habit over into your job you'll be in a world of hurt.
What life style changes do you suppose I make? I eat healthy, I exercise even though I get zero benefit, and I maintain my social and work life. Please enlighten me.