JustPanicNoDisco
Member
@Coconutz did you have any erections issues prior to starting exogenous estradiol? I know some guys have reported ED while others just report low libido and feeling like shit. It's a wide spectrum.
From what I've read, it appears estrogen receptors (specifically, ER-alpha receptors) have some governance over the expression of androgen receptors, so without the former, the latter can definitely not work optimally. Potentially this is why guys report not "feeling" testosterone and other androgenics/anabolics when their estro signaling is impaired.
From what I've read, it appears estrogen receptors (specifically, ER-alpha receptors) have some governance over the expression of androgen receptors, so without the former, the latter can definitely not work optimally. Potentially this is why guys report not "feeling" testosterone and other androgenics/anabolics when their estro signaling is impaired.