Oral TRT Products: Jatenzo, Tlando, Kyzatrex, & DiTest

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Fortunate said:
I have tried Jatenzo on a few occasions, but never got to seven days.
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Have you tried Jatenzo after no injections for a couple of weeks?

Stacking both may be causing your problems. I felt bad on Jatenzo 2, 3 and 4th week and I’ll bet it has to do with the cypionate leaving my system and my T levels dropping back into the normal ranges.
 
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Systemlord said:
Have you tried Jatenzo after no injections for a couple of weeks?

Stacking both may be causing your problems. I felt bad on Jatenzo 2, 3 and 4th week and I’ll bet it has to do with the cypionate leaving my system and my T levels dropping back into the normal ranges.
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Guilty as charged. My feedback is virtually useless as I barely got past a few days.
 
JohnnyQuest said:
No miracles, LOL. But I'll also add this. I didn't have any problems in the bedroom with my wife, but my urologist asked me one day if I'd like to be like 17 again, and I said I was open to trying it. He gave me 5mg daily of Cialis, and wow, what a difference. I was really surprised by it. I'm also highly interested in the other benefits it offers. if you haven't read about it, see this thread - it's one of the best ones I've seen here:

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The benefits of long term use of Cialis

An oldie but goodie...still relevant today as it was then. Good shit! The Benefits of Long Term Cialis Use Cialis (tadalafil) is powerful.. What makes Cialis unique among the erectile dysfunction drugs is its long half life. Thirty six hours after taking Cialis, a guy will still have about a...
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Already on that and unfortunately dealing with pretty severe Peyronies.
 
I thought orals were less ideal as caused higher stress on liver esp as take MUCH MUCH larger doses per week. is that false? or was more so with woman oral hormones?

of course risks and benefits to every form so would be interested if anyone has noted elevated liver enzymes etc.
 
granger said:
I thought orals were less ideal as caused higher stress on liver esp as take MUCH MUCH larger doses per week. is that false? or was more so with woman oral hormones?
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Only true for the old methyl testosterone. Oral testosterone undecanoate does not stress the liver.

In contrast to some other oral testosterone forms, testosterone undecanoate enters the bloodstream via the lymphatic system rather than the portal vein. This is important because substances that enter the bloodstream through the portal vein go directly to the liver.

This "first pass" through the liver can be harmful for certain substances, as it may lead to liver damage. Some oral anabolic steroids, for example, have been linked to liver toxicity due to this first-pass metabolism. However, because testosterone undecanoate is absorbed by the lymphatic system, it bypasses this first pass through the liver, thereby reducing the potential for liver toxicity.

This is a prime example of how the method of drug administration can greatly impact its safety profile. Nonetheless, while oral testosterone undecanoate does not have the same risk for liver toxicity as some other oral steroids, it's essential to use it responsibly and under the guidance of a healthcare provider due to other potential side effects.
 
granger said:
I thought orals were less ideal as caused higher stress on liver esp as take MUCH MUCH larger doses per week. is that false? or was more so with woman oral hormones?

of course risks and benefits to every form so would be interested if anyone has noted elevated liver enzymes etc.
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FDA-Approved Oral Testosterone: Jatenzo (Testosterone Undecanoate)

The U.S. Food and Drug Administration today approved Jatenzo (testosterone undecanoate), an oral testosterone capsule to treat men with certain forms of hypogonadism. These men have low testosterone levels due to specific medical conditions, such as genetic disorders like Klinefelter syndrome or...
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cool, def would be interesting to see anecdotal liver enzymes before and after. would be interesting if would have increase risk of lymphatic cancer growths vs other test.

pretty poor absorption obv, so would be interesting how much untouched passes through stool or if ends up being broken down in the gut. or simply destroyed

also INTERESTING HELPS liver.... but also curious if the other subset got an INCREASE in hepatic fat content, and this subset was just guys who lost weight on trt.
"terestingly, a prodrug of TLANDO, LPCN 1144 (Lipocine, Inc., Salt Lake City, UT, USA) was also noted to decrease the hepatic fat content in a subset of patients from the ambulatory blood pressure trial, and its benefit in treating non-alcoholic fatty liver disease, which is associated with male hypogonadism, is currently being studied."

also a small note said oral test tends to increase hemocrit more "and needs to be studied why this oral form does this" I thought all trt is likely to cause this, some more than others..

not hating, but skeptical hippo eyes just because dose is sooo high, like with most things takes awhile to figure out all the side effects. but also may just be a great TRT option..

but ya, waiting with bated breath how folks labs change esp with liver/hemocrit. not much easier than pills! no cross contamination, no embolism/infections, and presumably less HPTA shut down as short acting... neat stuff
 

Comparison of Jatenzo, Kyzatrex, and Tlando​

Overview​

Jatenzo, Kyzatrex, and Tlando are all oral testosterone undecanoate (TU) formulations used for testosterone replacement therapy (TRT) in men with hypogonadism. These medications offer an alternative to traditional intramuscular injections and topical gels, providing a more convenient oral administration route.

Mechanism of Action​

All three drugs work by replacing the testosterone that is not being produced naturally by the body. They are metabolized through the lymphatic system, which helps avoid liver toxicity, a significant issue with earlier oral testosterone formulations.

Dosage and Administration​

  • Jatenzo: The recommended starting dose is 237 mg taken orally twice daily with food. The dosage can be adjusted based on serum testosterone levels, with a range from 158 mg to 396 mg twice daily.
  • Kyzatrex: The starting dose is 200 mg taken orally twice daily with food. The dosage can be adjusted based on serum testosterone levels, with a range from 100 mg once daily to 400 mg twice daily.
  • Tlando: The recommended dose is 225 mg taken orally twice daily with food. Unlike Jatenzo and Kyzatrex, Tlando does not require dose adjustments.

Efficacy​

  • Jatenzo: In clinical trials, Jatenzo achieved eugonadal testosterone levels in 87% of participants. It has shown significant improvements in sexual and mood symptoms, bone mineral density, and lean body mass.
  • Kyzatrex: In a phase III trial, 96.1% of participants achieved normal testosterone levels after 90 days. The drug was well-tolerated, with no serious adverse events reported.
  • Tlando: Approximately 80% of subjects attained testosterone levels within the eugonadal range in clinical studies. Tlando has also shown beneficial effects on sexual and mood symptoms.

Side Effects​

  • Jatenzo: Common side effects include gastrointestinal reactions (nausea, diarrhea) and a small but significant increase in systolic blood pressure (4.9 mmHg).
  • Kyzatrex: The most notable side effect is a slight increase in systolic blood pressure (1.7 mmHg). No serious adverse events were observed in the study.
  • Tlando: Similar to Jatenzo, Tlando has been associated with increases in blood pressure and prolactin levels. The mean increase in systolic blood pressure was 3.8 mmHg.

Cost and Insurance​

The cost and insurance coverage for these medications can vary. All three drugs are prescription-only and may present a barrier for some patients due to cost and lack of insurance coverage.

Conclusion​

Jatenzo, Kyzatrex, and Tlando offer effective and convenient oral options for testosterone replacement therapy. Each has its own dosing regimen and side effect profile, but all have shown to be effective in achieving normal testosterone levels in hypogonadal men. The choice between these medications may depend on individual patient needs, side effect tolerance, and cost considerations.


Citations:
[1] Jatenzo vs Tlando Comparison - Drugs.com
[2] Oral Drugs Offer New Option for Testosterone Replacement
[3] A phase III, single-arm, 6-month trial of a wide-dose range oral testosterone undecanoate product
[4] Oral Testosterone Replacement Therapy: What’s Available and What Took so Long? - American Urological Association
[5] Kyzatrex vs Tlando Comparison - Drugs.com
[6] https://www.goodrx.com/classes/androgens/oral-testosterone-vs-injection
[7] https://www.liebertpub.com/doi/full/10.1089/andro.2022.0011
[8] Testosterone oral agents (JATENZO, TLANDO) - www.westernhealth.com
[9] Testosterone Replacement Therapy: A Narrative Review with a Focus on New Oral Formulations
[10] A Review of Testosterone Therapy Options for Men
[11] https://www.touchendocrinology.com/...review-with-a-focus-on-new-oral-formulations/
[12] https://liebertpub.com/doi/full/10.1089/andro.2021.0025
[13] Testosterone Update on Oral Products
 
BigBeard411 said:
where is the cheapest place I can get Kyzatrex with no insurance?
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One average $149 and even then keep in mind this is for the starting dose 200 mg 2x/day.

Some men will not achieve high enough levels on such and may need to titrate up to 300 or 400 mg dosed twice daily (600-800 mg/day)!

Look over post #48!




post #6/48
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KYZATREX (oral testosterone undecanoate) now available in all states across the US

https://www.kyzatrex.com/prescriber.html KYZATREX (testosterone undecanoate) is an oral testosterone replacement therapy specifically designed for adult males with conditions associated with a deficiency or absence of endogenous testosterone, such as primary hypogonadism and hypogonadotropic...
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madman said:
One average $149 and even then keep in mind this is for the starting dose 200 mg 2x/day.

Some men will not achieve high enough levels on such and may need to titrate up to 300 or 400 mg dosed twice daily (600-800 mg/day)!

Look over post #48!




post #6/48
www.excelmale.com

KYZATREX (oral testosterone undecanoate) now available in all states across the US

https://www.kyzatrex.com/prescriber.html KYZATREX (testosterone undecanoate) is an oral testosterone replacement therapy specifically designed for adult males with conditions associated with a deficiency or absence of endogenous testosterone, such as primary hypogonadism and hypogonadotropic...
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High-Dose Oral TU Kyzatrex in Men with Low Testosterone: Safety, Efficacy, and Patient Satisfaction

Hot off the press! You heard it here first, Nelson's domain is where it's at! High-dosed oral TU (Kyzatrex 400 mg) BID, LH/FSH while lower were maintained at non-zero levels, minimal impact on hematocrit! *At a mean follow up time of 6 months, patients demonstrated a significant increase in...
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I have heard Kyzatrex can reverse testicular atrophy to some extent versus injectables, is this correct?

Is it reasonable to expect similar free and total T numbers on Kyzatrex as e.g. EOD test cyp injections or is there an upper limit?
 
Beyond Testosterone Book by Nelson Vergel
donkeyfarlo said:
I have heard Kyzatrex can reverse testicular atrophy to some extent versus injectables, is this correct?

Is it reasonable to expect similar free and total T numbers on Kyzatrex as e.g. EOD test cyp injections or is there an upper limit?
Click to expand...

I have heard Kyzatrex can reverse testicular atrophy to some extent versus injectables, is this correct?


Kyzatrex (oral TU) dosed 2x daily will result in less suppression of the hpta than injectable esterified T due to the PK which will result in 2 shorter-lived daily peaks with longer trough times between doses.

The trough levels achieved (sub-physiologic) are nothing to brag about!

From the most recent pilot study I uploaded in (post #8).

High-dosed oral TU (Kyzatrex 400 mg) BID, LH/FSH while lower were maintained at non-zero levels, minimal impact on hematocrit!

None of the patients reported testicular atrophy.

Even then need to keep in mind the only way for an individual to truly know how much testicular shrinkage occurred would be to have testicular volume measured using a prader orchidometer or ultrasonography pre/post TRT.

You would never truly know playing the guessing game!




www.excelmale.com

High-Dose Oral TU Kyzatrex in Men with Low Testosterone: Safety, Efficacy, and Patient Satisfaction

Hot off the press! You heard it here first, Nelson's domain is where it's at! High-dosed oral TU (Kyzatrex 400 mg) BID, LH/FSH while lower were maintained at non-zero levels, minimal impact on hematocrit! *At a mean follow up time of 6 months, patients demonstrated a significant increase in...
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*At a mean follow up time of 6 months, patients demonstrated a significant increase in TT (263 to 798 ng/dL), drop in SHBG (32.4 to 17.83 nmol/L), and increase in calculated fT (7.24 to 26.74 ng/dL). FSH and LH, while lower, were maintained at non-zero levels (FSH from 5.7 to 2.9 mIU/mL and LH from 3.3 to 1.9 mIU/mL). Estradiol modestly increased (20.5 to 24.7 pg/mL) while hematocrit did not significantly increase (44.9% to 47.4%). No patients reported testicular atrophy or were initiated on aromatase inhibitors. One patient had a hematocrit rise above 52% (53.2%) and was reduced to 300 mg BID.


* Initiating oral TU therapy with Kyzatrex at 400 mg BID is safe and effective in achieving therapeutic serum testosterone levels. The high dose was well-tolerated and resulted in substantial symptom improvement, high patient satisfaction, and adherence. These findings support considering a higher starting dose for hypogonadal men considering oral TU therapy.




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Effect of Oral Testosterone Undecanoate on LH and FSH Concentrations

Introduction Treatment of male hypogonadism with testosterone (T), most profoundly with long-acting injections and pellets, has been shown to inhibit the hypogonadal-pituitary-gonadal (HPG) axis[4]. T injections result in a reduction in both luteinizing hormone (LH) and follicle-stimulating...
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Also keep in mind there are only 2 other studies on oral TU/gonadotropins using Jatenzo and one was short-term (2 weeks) which had minimal impact while the other study was much longer (16 weeks) and showed a strong suppression of LH/FSH.

Suppression of LH 75%!

Again the most recent pilot study using high-dosed oral TU (Kyzatrex 400 mg) BID mean follow-up time 6 months LH/FSH while lower were maintained at non-zero levels.

Other than nasal T gel (Natesto) any form of exogenous whether T pellets, oral esterified T (Jatenzo), transdermal gels/creams, injectable esterified T when used in therapeutic doses to treat low testosterone will have a strong impact on suppression on the hpta.

Formulation/PKs, dosing protocol/minimum effective doses needed to raise T levels in order to achieve a healthy FT level in order to provide relief/improvement of symptoms will results in suppression of the hpta.

Long and medium-acting injectable esterified TU/TC/TE/mixed will have the strongest impact.

Even short-acting injectable esterified TP can still have a strong suppressive effect on the hpta

As I stated in a previous thread when using daily short-acting TP the T levels achieved peak vs trough let alone the time period over those 24 hrs T levels are elevated whether mid-range/high/absurdly high will still result in a strong suppression of the hpta.

Top it off there are many injecting daily TP hitting very high/absurdly high peaks let alone healthy troughs.

Next would be oral TU (Jatenzo) and transdermals.

Nasal T gel would be the least suppressive due to the PK/dosing protocol.

Any formulation that has a strong suppressive effect on the hpta will result in testicular shrinkage and negative effect on fertility/spermatogenesis.

As you would know the addition of an LH mimetic (hCG) will allow one to maintain some degree of intra-testicular testosterone (ITT) which will helps minimize/prevent testicular atrophy and maintain fertility while using exogenous T.

The addition of hCG + rFSH would be more effective!








Is it reasonable to expect similar free and total T numbers on Kyzatrex as e.g. EOD test cyp injections or is there an upper limit?


Looking over any of the studies done using oral TU one can easily achieve a high-end and in some cases very high peak TT/FT level let alone a small % of outliers have been able to hit an absurdly high peak!

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FDA Approves Oral Testosterone Replacement Therapy Kyzatrex

Another oral testosterone undecanoate. https://www.empr.com/home/news/fda-approves-oral-testosterone-replacement-therapy-kyzatrex/
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*The percentage of patients who received KYZATREX and had testosterone Cmax threshold less than or equal to 1200 ng/dL, between 1440 and 2000 ng/dL, and greater than 2000 ng/dL at the final PK visit were 88%, 4%, and 0%, respectively.


*The percentage of patients who received JATENZO and had Cmax less than or equal to 1500 ng/dL, between 1800 and 2500 ng/dL, and greater than 2500 ng/dL at the final PK visit were 83%, 3%, and 3%, respectively.


* The percentage of patients who received TLANDO and had a T Cmax threshold less than or equal to 1620 ng/dL, between 1944 ng/dL and 2700 ng/dL, and greater than 2700 ng/dL at the PK visit were 82%, 5%, and 0%, respectively.


Keep in mind dose used/absorption of T is what matters as the bioavailability is very low compared to injections.

Dose titration (Jatenzo or Kyzatrex) needs to be kept in mind as not everyone will fare well or hit a high enough T level with the starting doses.

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KYZATREX (oral testosterone undecanoate) now available in all states across the US

Did you get any nasty side effects by the way? None. I am looking at all the warnings and one of them says increase risk of death. That's a load of sh**! There's an increase risk of death living life, like crossing the street. There's increase risk of death with any other medicines.
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Even then one could never achieve the TT/FT (peak/trough) let alone steady-state levels that one can easily attain when using injectable T due to the dose of T/bioavailability/PK.

As I stated in a previous thread:

Keep in mind if your goal is to take advantage of the anabolic properties of T then injectables are where it's at as one can easily attain high/absurdly high trough FT levels.

When it comes to reaping the full anabolic benefits not only is having supra-physiological levels of FT steady-state 24/7 important but also how high you drive up FT levels.

When it comes to packing on size/mass/strength T is king!

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Kyzatrex or Jatenzo

Good day all. I've been on testosterone cypionate almost 7 years. I inject anywhere from 100 to 120 mg in total divided 2 times a week. Am 47. I'm feeling good consistently for years now. Looks like my insurance cover oral testosterone. I did read some threads on here, I see system Lord is...
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Would definitely look into giving oral TU (Kyzatrex) a go if you are interested!
 
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