Oral TRT Products: Jatenzo, Tlando, Kyzatrex, & DiTest

[Systemlord]

I have tried Jatenzo on a few occasions, but never got to seven days.

Have you tried Jatenzo after no injections for a couple of weeks?

Stacking both may be causing your problems. I felt bad on Jatenzo 2, 3 and 4th week and I’ll bet it has to do with the cypionate leaving my system and my T levels dropping back into the normal ranges.

 

[Fortunate]

Have you tried Jatenzo after no injections for a couple of weeks?

Stacking both may be causing your problems. I felt bad on Jatenzo 2, 3 and 4th week and I’ll bet it has to do with the cypionate leaving my system and my T levels dropping back into the normal ranges.

Guilty as charged. My feedback is virtually useless as I barely got past a few days.

 

[JM Kane]

No miracles, LOL. But I'll also add this. I didn't have any problems in the bedroom with my wife, but my urologist asked me one day if I'd like to be like 17 again, and I said I was open to trying it. He gave me 5mg daily of Cialis, and wow, what a difference. I was really surprised by it. I'm also highly interested in the other benefits it offers. if you haven't read about it, see this thread - it's one of the best ones I've seen here:

The benefits of long term use of Cialis

An oldie but goodie...still relevant today as it was then. Good shit! The Benefits of Long Term Cialis Use Cialis (tadalafil) is powerful.. What makes Cialis unique among the erectile dysfunction drugs is its long half life. Thirty six hours after taking Cialis, a guy will still have about a...

www.excelmale.com

Already on that and unfortunately dealing with pretty severe Peyronies.

 

[granger]

I thought orals were less ideal as caused higher stress on liver esp as take MUCH MUCH larger doses per week. is that false? or was more so with woman oral hormones?

of course risks and benefits to every form so would be interested if anyone has noted elevated liver enzymes etc.

 

[Nelson Vergel]

I thought orals were less ideal as caused higher stress on liver esp as take MUCH MUCH larger doses per week. is that false? or was more so with woman oral hormones?

Only true for the old methyl testosterone. Oral testosterone undecanoate does not stress the liver.

In contrast to some other oral testosterone forms, testosterone undecanoate enters the bloodstream via the lymphatic system rather than the portal vein. This is important because substances that enter the bloodstream through the portal vein go directly to the liver.

This "first pass" through the liver can be harmful for certain substances, as it may lead to liver damage. Some oral anabolic steroids, for example, have been linked to liver toxicity due to this first-pass metabolism. However, because testosterone undecanoate is absorbed by the lymphatic system, it bypasses this first pass through the liver, thereby reducing the potential for liver toxicity.

This is a prime example of how the method of drug administration can greatly impact its safety profile. Nonetheless, while oral testosterone undecanoate does not have the same risk for liver toxicity as some other oral steroids, it's essential to use it responsibly and under the guidance of a healthcare provider due to other potential side effects.

 

[madman]

I thought orals were less ideal as caused higher stress on liver esp as take MUCH MUCH larger doses per week. is that false? or was more so with woman oral hormones?

of course risks and benefits to every form so would be interested if anyone has noted elevated liver enzymes etc.

FDA-Approved Oral Testosterone: Jatenzo (Testosterone Undecanoate)

The U.S. Food and Drug Administration today approved Jatenzo (testosterone undecanoate), an oral testosterone capsule to treat men with certain forms of hypogonadism. These men have low testosterone levels due to specific medical conditions, such as genetic disorders like Klinefelter syndrome or...

www.excelmale.com

 

[granger]

cool, def would be interesting to see anecdotal liver enzymes before and after. would be interesting if would have increase risk of lymphatic cancer growths vs other test.

pretty poor absorption obv, so would be interesting how much untouched passes through stool or if ends up being broken down in the gut. or simply destroyed

also INTERESTING HELPS liver.... but also curious if the other subset got an INCREASE in hepatic fat content, and this subset was just guys who lost weight on trt.
"terestingly, a prodrug of TLANDO, LPCN 1144 (Lipocine, Inc., Salt Lake City, UT, USA) was also noted to decrease the hepatic fat content in a subset of patients from the ambulatory blood pressure trial, and its benefit in treating non-alcoholic fatty liver disease, which is associated with male hypogonadism, is currently being studied."

also a small note said oral test tends to increase hemocrit more "and needs to be studied why this oral form does this" I thought all trt is likely to cause this, some more than others..

not hating, but skeptical hippo eyes just because dose is sooo high, like with most things takes awhile to figure out all the side effects. but also may just be a great TRT option..

but ya, waiting with bated breath how folks labs change esp with liver/hemocrit. not much easier than pills! no cross contamination, no embolism/infections, and presumably less HPTA shut down as short acting... neat stuff

 

[Nelson Vergel]

THE STATE OF ORAL TRT: FEELING THE IMPACT OF TRENDS IN PRACTICE AND PATIENT CARE

www.excelmale.com

 

[Nelson Vergel]

Comparison of Jatenzo, Kyzatrex, and Tlando​

Overview​

Jatenzo, Kyzatrex, and Tlando are all oral testosterone undecanoate (TU) formulations used for testosterone replacement therapy (TRT) in men with hypogonadism. These medications offer an alternative to traditional intramuscular injections and topical gels, providing a more convenient oral administration route.

Mechanism of Action​

All three drugs work by replacing the testosterone that is not being produced naturally by the body. They are metabolized through the lymphatic system, which helps avoid liver toxicity, a significant issue with earlier oral testosterone formulations.

Dosage and Administration​

• Jatenzo: The recommended starting dose is 237 mg taken orally twice daily with food. The dosage can be adjusted based on serum testosterone levels, with a range from 158 mg to 396 mg twice daily.
• Kyzatrex: The starting dose is 200 mg taken orally twice daily with food. The dosage can be adjusted based on serum testosterone levels, with a range from 100 mg once daily to 400 mg twice daily.
• Tlando: The recommended dose is 225 mg taken orally twice daily with food. Unlike Jatenzo and Kyzatrex, Tlando does not require dose adjustments.

Efficacy​

• Jatenzo: In clinical trials, Jatenzo achieved eugonadal testosterone levels in 87% of participants. It has shown significant improvements in sexual and mood symptoms, bone mineral density, and lean body mass.
• Kyzatrex: In a phase III trial, 96.1% of participants achieved normal testosterone levels after 90 days. The drug was well-tolerated, with no serious adverse events reported.
• Tlando: Approximately 80% of subjects attained testosterone levels within the eugonadal range in clinical studies. Tlando has also shown beneficial effects on sexual and mood symptoms.

Side Effects​

• Jatenzo: Common side effects include gastrointestinal reactions (nausea, diarrhea) and a small but significant increase in systolic blood pressure (4.9 mmHg).
• Kyzatrex: The most notable side effect is a slight increase in systolic blood pressure (1.7 mmHg). No serious adverse events were observed in the study.
• Tlando: Similar to Jatenzo, Tlando has been associated with increases in blood pressure and prolactin levels. The mean increase in systolic blood pressure was 3.8 mmHg.

Cost and Insurance​

The cost and insurance coverage for these medications can vary. All three drugs are prescription-only and may present a barrier for some patients due to cost and lack of insurance coverage.

Conclusion​

Jatenzo, Kyzatrex, and Tlando offer effective and convenient oral options for testosterone replacement therapy. Each has its own dosing regimen and side effect profile, but all have shown to be effective in achieving normal testosterone levels in hypogonadal men. The choice between these medications may depend on individual patient needs, side effect tolerance, and cost considerations.


Citations:
[1] Jatenzo vs Tlando Comparison - Drugs.com
[2] Oral Drugs Offer New Option for Testosterone Replacement
[3] A phase III, single-arm, 6-month trial of a wide-dose range oral testosterone undecanoate product
[4] Oral Testosterone Replacement Therapy: What’s Available and What Took so Long? - American Urological Association
[5] Kyzatrex vs Tlando Comparison - Drugs.com
[6] https://www.goodrx.com/classes/androgens/oral-testosterone-vs-injection
[7] https://www.liebertpub.com/doi/full/10.1089/andro.2022.0011
[8] Testosterone oral agents (JATENZO, TLANDO) - www.westernhealth.com
[9] Testosterone Replacement Therapy: A Narrative Review with a Focus on New Oral Formulations
[10] A Review of Testosterone Therapy Options for Men
[11] https://www.touchendocrinology.com/...review-with-a-focus-on-new-oral-formulations/
[12] https://liebertpub.com/doi/full/10.1089/andro.2021.0025
[13] Testosterone Update on Oral Products