KYZATREX (oral testosterone undecanoate) now available in all states across the US

KYZATREX™ (testosterone undecanoate capsules)

The Power of Hormonal Balance | Restore your T- levels with Two KYZATREX capsules a day. | Discover KYZATREX Rediscover CONFIDENCE | A solution sans needles, gels, or creams

www.kyzatrex.com

KYZATREX (testosterone undecanoate) is an oral testosterone replacement therapy specifically designed for adult males with conditions associated with a deficiency or absence of endogenous testosterone, such as primary hypogonadism and hypogonadotropic hypogonadism 1112. Here is detailed information regarding its dosage, usage, side effects, price, and efficacy:

Dosage​

KYZATREX is available in capsule form in three dosage strengths: 100 mg, 150 mg, and 200 mg. The recommended starting dose is 200 mg taken orally twice daily, once in the morning and once in the evening, with food to enhance absorption 2412. Dosage adjustments are made based on serum testosterone levels measured 3 to 5 hours after the morning dose, at least 7 days after starting treatment or following a dose adjustment 45.

Usage​

KYZATREX capsules should be taken with food. The therapy is initiated only after confirming hypogonadism through appropriate tests that show serum testosterone concentrations below the normal range. It is important to monitor blood pressure regularly due to the risk of hypertension associated with its use 1012.

Side Effects​

Common side effects include increased blood pressure, which may necessitate the use of antihypertensive medications. Other potential side effects are acne, pain at the injection site, increased red blood cell count, and mood changes. Serious side effects may include major adverse cardiovascular events such as heart attacks and strokes11517.

Price​

The price of KYZATREX can vary depending on the pharmacy, insurance coverage, and dosage. It is advisable to consult with a healthcare provider or pharmacist for the most accurate pricing information.

Efficacy​

KYZATREX has shown high efficacy in clinical trials, with up to 96% of patients achieving normal testosterone levels within 90 days of treatment. The therapy effectively manages symptoms associated with testosterone deficiency, such as fatigue, low libido, and muscle loss 367. The formulation is designed to be absorbed through the lymphatic system, reducing the risk of liver toxicity commonly associated with oral testosterone treatments 18.

Additional Considerations​

KYZATREX carries a boxed warning regarding the potential for blood pressure increases and the associated risk of cardiovascular events. It is classified as a Schedule III controlled substance due to potential for misuse and abuse 1017. It is not indicated for use in women, particularly those who are pregnant, and it is not approved for treating low testosterone due to aging19.In summary, KYZATREX offers a significant advancement in the treatment of male hypogonadism, providing a convenient oral formulation that avoids the complications of other testosterone delivery methods like injections and gels. However, careful monitoring for side effects, particularly hypertension, is crucial.

 

Did you get any nasty side effects by the way?

None.

I am looking at all the warnings and one of them says increase risk of death.

That's a load of sh**! There's an increase risk of death living life, like crossing the street. There's increase risk of death with any other medicines.

 

Does anyone have the study with oral T where the doctor talks about taking the second dose early afternoon?

 

Does anyone have the study with oral T where the doctor talks about taking the second dose early afternoon?

There is no study using such dosing (early am/early afternoon) protocol.

Some uros especially Dr. Sun recommend such dosing protocol for some of their patients in order to maximize T levels during the day which would allow one to avoid the peak that would be achieved in the late evening after the second dose as some men may feel too amped up which can cause numerous issues for some especially when it comes to getting quality sleep.

I already posted the link for the interview with Dr. Sun in post #28 of this thread.

 

There is no study using such dosing (early am/early afternoon) protocol.

Some uros especially Dr. Sun recommend such dosing protocol for some of their patients in order to maximize T levels during the day which would allow one to avoid the peak that would be achieved in the late evening after the second dose as some men may feel too amped up which can cause numerous issues for some especially when it comes to getting quality sleep.

I already posted the link for the interview with Dr. Sun in post #28 of this thread.


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Thanks I knew I saw it somewhere! Do you have any experience with this dosing schedule?

 

Amazon Pharmacy: CLARUS THERAPEUTICS JATENZO 237 MG CAPSULE (1 Capsule)

Amazon is showing a 30 day suppy is 600$. Thats seems sky high. I dont have any insurance, any other source? I called my doc and it will take 20 days for a new appointment after i missed my appointment call today....why is this 20x the price of normal testosterone?

I'm on Jatenzo @237 mg twice daily. I have libido and erections, not so on injections after a couple of weeks. The rapid and frequent spikes in hormones I believe is the reason for optimal response.

When on injections, I don't feel the anabolic effects even with similar hormone levels.

The other day I tested testosterone at 4 pm, 3 hours past my midpoint. I was still in the 400 range, having spent the morning and mid afternoon with testosterone at the top end of the ranges.

Jatenzo is the only formulation of TRT that has worked for me!

 

Amazon Pharmacy: CLARUS THERAPEUTICS JATENZO 237 MG CAPSULE (1 Capsule)

Amazon is showing a 30 day suppy is 600$. Thats seems sky high. I dont have any insurance, any other source? I called my doc and it will take 20 days for a new appointment after i missed my appointment call today....why is this 20x the price of normal testosterone?

Taking advantage here!

Forget amazon.

Things have recently changed here when it comes to the $$$ Jatenzo.

As I stated in a previous thread the cost for Jatenzo is absurd and luckily they were forced to offer a pay-out-of-pocket option recently due to trying to stay competitive with Kyzatrex and Tlando which already offered such.

Oral TU- IT’S GO TIME - HELPING YOU GET STARTED ON JATENZO®

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Can't get it up... Ferritin that is. Blood issues after 5 years. HCG related question. Labs attached.

I have been on TC for over 5 years with varying results, mostly positive until the last year. I have had to do a few blood donations within the last 3 years due to rising HCT. It dropped my ferritin levels to 10, range 30 - 400. I can't get my ferritin levels up. My Mayo PCP said that if I take...

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Kyzatrex or Jatenzo

Good day all. I've been on testosterone cypionate almost 7 years. I inject anywhere from 100 to 120 mg in total divided 2 times a week. Am 47. I'm feeling good consistently for years now. Looks like my insurance cover oral testosterone. I did read some threads on here, I see system Lord is...

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I think Kyzatrex's manufacturer set theirs up to $125/month self-pay. You can access doctors here: Get Started | Why Kyzatrex | Safe, Easy, Up to 96% Effective

 

Possible dose titration (Jatenzo or Kyzatrex) needs to be kept in mind when it comes to the cost as not everyone will fare well or hit a high enough T level with the starting doses.

A phase III, single-arm, 6-month trial of a wide-dose range oral TU (Kyzatrex) product

Abstract Background Oral testosterone undecanoate (TU) formulations may provide effective, safe, and easily titratable testosterone replacement therapy. Objective Demonstrate efficacy and safety of a novel oral TU formulation. Design An open-label, single-arm, multi-center trial treated...

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Dose and impact of baseline characteristics.

The distribution of final doses is provided in Figure 3. The logistic regression analysis of the impact of baseline characteristics on final dose demonstrated that body weight and diabetic status were positively associated with higher final dose (⩽400, 600, or 800mg) with odds ratios of 3.928 (95% CI: 1.896–8.137) and 2.646 (95% CI: 1.111–6.300), respectively. In contrast, use of antihypertensive medication had no influence on final dose.


Figure 3. Final dose distributions after 90 days of treatment with KYZATREX

ORAL TU (316 MG BID) QUICKLY AND EFFECTIVELY INCREASES SERUM T CONCENTRATIONS IN HYPOGONADAL MEN

INTRODUCTION AND OBJECTIVE Over 2.4 million US men have hypogonadism, defined as serum testosterone (T) levels

www.excelmale.com

*Overall, 316 mg TU BID quickly and effectively increased serum T concentrations above 450 ng/dL in 77% of hypogonadal men. The wide distribution of serum T concentrations for the same dose (e.g., 23% <450 ng/dL and 27% 1000 ng/dL) suggests that men likely respond differently to T replacement therapy. Future studies and investigations should evaluate patient factors that impact the magnitude of T increases allowing for more individualized titrations.

 

Marius Pharmaceuticals Submits KYZATREX® (oral TU) CIII Capsules for Approval to Health Canada

It was just a matter of time! F**king A! Looks like they may have beat out Verity Pharmaceuticals oral Tlando for dibs on the Canadian market! RALEIGH, N.C., July 30, 2024 (GLOBE NEWSWIRE) -- Marius Pharmaceuticals, a patient-centric healthcare company focused on developing innovative...

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Has anyone found a cheaper way to get Jatenzo than the 150 per month?

 

Possible dose titration (Jatenzo or Kyzatrex) needs to be kept in mind when it comes to the cost as not everyone will fare well or hit a high enough T level with the starting doses.

A phase III, single-arm, 6-month trial of a wide-dose range oral TU (Kyzatrex) product

Abstract Background Oral testosterone undecanoate (TU) formulations may provide effective, safe, and easily titratable testosterone replacement therapy. Objective Demonstrate efficacy and safety of a novel oral TU formulation. Design An open-label, single-arm, multi-center trial treated...

www.excelmale.com

Dose and impact of baseline characteristics.

The distribution of final doses is provided in Figure 3. The logistic regression analysis of the impact of baseline characteristics on final dose demonstrated that body weight and diabetic status were positively associated with higher final dose (⩽400, 600, or 800mg) with odds ratios of 3.928 (95% CI: 1.896–8.137) and 2.646 (95% CI: 1.111–6.300), respectively. In contrast, use of antihypertensive medication had no influence on final dose.


Figure 3. Final dose distributions after 90 days of treatment with KYZATREX
View attachment 45318

ORAL TU (316 MG BID) QUICKLY AND EFFECTIVELY INCREASES SERUM T CONCENTRATIONS IN HYPOGONADAL MEN

INTRODUCTION AND OBJECTIVE Over 2.4 million US men have hypogonadism, defined as serum testosterone (T) levels

www.excelmale.com

*Overall, 316 mg TU BID quickly and effectively increased serum T concentrations above 450 ng/dL in 77% of hypogonadal men. The wide distribution of serum T concentrations for the same dose (e.g., 23% <450 ng/dL and 27% 1000 ng/dL) suggests that men likely respond differently to T replacement therapy. Future studies and investigations should evaluate patient factors that impact the magnitude of T increases allowing for more individualized titrations.





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Oral TU Quickly and Effectively Achieves Serum Testosterone ≥300 NG/DL in Most Hypogonadal Men Without Dose Titrations

* Overall, the starting dose of 237 mg TU BID quickly and effectively increased serum T concentrations ≥300 ng/dL in 85% of hypogonadal men. The wide distribution of serum T concentrations for the same dose (e.g., 15%

www.excelmale.com

Conclusions:

Overall, the starting dose of 237 mg TU BID quickly and effectively increased serum T concentrations ≥300 ng/dL in 85% of hypogonadal men. The wide distribution of serum T concentrations for the same dose (e.g., 15% <300 ng/d and 12% ≥1000 ng/dL) suggests that men likely respond differently to T replacement therapy. Therefore, an oral T replacement therapy that allows for dose titration would likely be preferable to a fixed dose. Future studies and investigations should evaluate patient factors that impact the magnitude of T increases allowing for more individualized titrations.

 

Understanding Testosterone and Muscle Preservation

www.excelmale.com

00:29:13 - Oral vs Injectable Testosterone: Benefits and Comparisons

01:05:55 - Kyzatrex: A New Approach to Testosterone Delivery




If your goal is to minimize chances of driving up hematocrit let alone hitting a high-end short-lived daily peak twice daily then 400 mg BID is most likely the way to achieve such unless you are one of those hyper responders who will fare well on a lower daily dose!

High-Dose Oral TU Kyzatrex in Men with Low Testosterone: Safety, Efficacy, and Patient Satisfaction

Hot off the press! You heard it here first, Nelson's domain is where it's at! High-dosed oral TU (Kyzatrex 400 mg) BID, LH/FSH while lower were maintained at non-zero levels, minimal impact on hematocrit! *At a mean follow up time of 6 months, patients demonstrated a significant increase in...

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*At a mean follow up time of 6 months, patients demonstrated a significant increase in TT (263 to 798 ng/dL), drop in SHBG (32.4 to 17.83 nmol/L), and increase in calculated fT (7.24 to 26.74 ng/dL). FSH and LH, while lower, were maintained at non-zero levels (FSH from 5.7 to 2.9 mIU/mL and LH from 3.3 to 1.9 mIU/mL). Estradiol modestly increased (20.5 to 24.7 pg/mL) while hematocrit did not significantly increase (44.9% to 47.4%). No patients reported testicular atrophy or were initiated on aromatase inhibitors. One patient had a hematocrit rise above 52% (53.2%) and was reduced to 300 mg BID.

* Initiating oral TU therapy with Kyzatrex at 400 mg BID is safe and effective in achieving therapeutic serum testosterone levels. The high dose was well-tolerated and resulted in substantial symptom improvement, high patient satisfaction, and adherence. These findings support considering a higher starting dose for hypogonadal men considering oral TU therapy.

Minimizing Erythrocytosis during TRT (Daily injectable Testosterone vs. Gels vs. Kyzatrex)

All, I react very badly to injectable T (56 hematocrit @ 100 mg split 3x per week SubQ). My ferritin suffers greatly here and sits in the 20's to low 30's. I want it to be above 70. Testosterone have given me a severe case of periodic limb movement disorder due to low dopamine resulting (I...

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