Will do. I’ll probably get labs after about a month. Defy told me that they’ve had several requests for it this week alone, so maybe they’re more open to it. They seemed supportive of giving it a try when I asked.
I feel like I've been shafted. I really wanted to give this a try. Cataceous even put in a call for me. Maybe by the time I'm due for a follow-up, Natesto/TNG will have gotten overwhelmingly popular and they won't fight me on trying it.
I think that's wise. If we can assume 10 mg is going to give you roughly twice the serum levels of Natesto then it could push those testosterone peaks up to as much as 1,400-1,500 ng/dL. Aside from being supraphysiological, this possibly would cause more significant HPTA suppression, in spite of the short half-life.
Libido didn’t seem to improve with OP, although the studies that have been shared here seem to suggest otherwise, at least when compared to users’ experience with Clomid.
There's no guarantee the absorbed amounts are equivalent when different concentrations are used, but it could be worth trying if you don't mind some experimentation.
@Cataceous @madman
www.excelmale.com
Presumably with these methods it's the unusual serum testosterone profile that reduces HPTA suppression. What's interesting is that this seems to be less important in primary hypogonadism. That is, at least anecdotally, guys with primary seem to be able to tune their LH just by varying their doses, even when injecting longer testosterone esters.Comparison of Testosterone Blood Concentrations from Different TRT Products Versus Normal Diurnal Variations
Abstract Background: To improve symptoms associated with testosterone deficiency (TD), many testosterone therapies (TTh) are available that aim to restore serum testosterone (T) levels to the normal physiologic range. The magnitude, frequency, and duration between peak and trough T...
*Men using nasal and oral T products are able to achieve mean serum T levels that are within the normal range, but they experience several T peaks and troughs throughout the day because of the multiple daily dosing regimens required (2 or 3 times/day). This results in a PK profile that significantly deviates from the endogenous PK profiles of both younger and older patients
*No single formulation appears to provide an exposure profile that would resemble diurnal variation of both young and older men
In line with what @madman says, I find rising serum testosterone interferes with sleep. I would have to take a third dose of nasal gel earlier in the evening. In one of the clinical trials the dosing times were "0700 h, 1300 h, and 2100 h". The night interval of 10 hours is the longest, which would make it possible to have declining levels by bedtime.
I tried the Empower version for 5 days. Just didn't like it. It does seem to build up in your nose, and occasionally you can feel it running down your throat, which isn't pleasant. I also felt like I was high (and actually tired) for a few hours after taking each dose, obviously due to the jump in testosterone, and I also had a minor headache every single day, which seemed to start shortly after using it. The application wasn't a huge deal, although I still felt like I was tied to a clock with the 3 times per day application. Admittedly, I probably haven't used it long enough to give it a fair shake, and I'd probably get used to it a bit more and make some adjustments, but at this point I prefer the feeling from Enclomiphene. One pill at night, more natural feeling throughout the day. I think I'll stick with Enclomiphene for the time being and play around with the frequency to find the best spot for me. If my numbers really start to drop or I start feeling awful, I'm open to jumping on the nasal gel again, particularly because my subjective feeling was that it likely did jump up my testosterone levels for that 1-2 hours. But I suppose I'm happy enough with Enclomiphene right now to make me not willing to spend time with the nasal gel waiting things out or finding the best approach.
Have you considered or tried taking enclomiphene + intranasal testosterone together? The enclomiphene would stimulate endogenous production and likely prevent suppression from a short-acting form of testosterone. You could use the intranasal testosterone more PRN/as needed vs. strictly 3x/day: such as prior to a workout, sexual activity, or a focused work session/important meeting.
I had the same feeling with Natesto
www.excelmale.com
I did notice a lot more random erections, libido probably increased a bit. So there was some good, and maybe that's a sign to me that in general my T is too low. The feeling in my nose and headache was just too annoying, although I'm not ready to give up on it completely, particularly since I only gave it a few days. Maybe a combination of enclomiphene with using this as a once or twice per day boost would be a good fit.I had the same feeling with Natesto
Post #17
FDA Approved Natesto Nasal Gel to Treat Men with Low Testosterone
Trimel Pharmaceuticals Corporation announced today (May 28.2014) that the United States Food and Drug Administration (FDA) has approved Natesto (testosterone), formerly CompleoTRT, the first and only testosterone nasal gel for replacement therapy in adult males for conditions associated with a...
Or even maybe just doing one nostril instead of both, or decreasing the nasal dosage by not going the full 8 "clicks" for a rotation. Might be enough to top things off without side effects.
I kinda agree with this. I believe Dr. Lipschultz is getting ready to study this.
Maybe consider the Natesto brand. I am prone to headaches and Natesto is literally the only form of TRT that does not give me a headache. The ingredient list is quite small while the list of ingredients in Defy's version is quite large. The headaches could be from one of the ingredients specific to the Defy formulation.
