I know that Natesto is a Nasal application product but due to getting sores in my nose I've recently tried applying it on the inside of my biceps.
It seems to absorb well and I actually feel it better than the nasal application.
Just curious to know of anyone has tried this before?
Like all testosterone products the information says that he gel can transfer to others so the absorption makes sense.....
You are wasting your time here.
Natesto is meant to/needs to be applied intranasally in order to reap the benefits of the PK.
In and out of your system quickly due to the half-life of unesterified T.
Dosed 2-3 times daily which results in a short-lived peak with long trough times between doses.
The main reason one would choose Natesto over any other form of exogenous T is that it will cause the least suppression of the hpta out of all the T formulations.
Minimal
testicular shrinkage and maintaining fertility without having to add in an ancillary like hCG to boot.
Minimal impact when it comes to side effects (cosmetic/blood markers), especially elevated hematocrit.
If you are dead set on transdermal application then you are far better off using a compounded T cream or big pharma gel.
Look over Figure 1 (PK) as this is the magic behind Natesto's minimal suppression of the hpta.
The key point here is a short-lived peak with long trough times between doses.
12.3. Pharmacokinetics
Absorption
Natesto delivers physiologic amounts of testosterone, producing circulating concentrations that approximate normal testosterone concentrations (i.e., 300 to 1,050 ng/dL) seen in healthy men. The maximum concentration for Natesto is achieved within approximately 40 minutes of administration and has a half-life ranging from 10 to 100 minutes.
Figure 1 summarizes the pharmacokinetic profiles of total testosterone in patients completing 90 days of Natesto treatment administered as 33 mg of testosterone daily (11 mg three times daily).
*Patients should be instructed to report any nasal symptoms or signs to their healthcare professional. In that circumstance, healthcare professionals should determine whether further evaluation (e.g., otorhinolaryngology consultation) or discontinuation of Natesto is appropriate.
5. WARNINGS AND PRECAUTIONS
5.1 Nasal Adverse Reactions and Limited Long-Term Information on Nasal Safety
Nasal adverse reactions, including nasopharyngitis, rhinorrhea, epistaxis, nasal discomfort, and nasal scabbing, were reported in the clinical trial experience with Natesto. All nasal adverse reactions except one (a single case of upper respiratory infection) were reported as mild or moderate in severity; however, long-term clinical trial data on nasal safety is available in a limited number of subjects [see Adverse Reactions (6.2)]. Patients should be instructed to report any nasal symptoms or signs to their healthcare professional. In that circumstance, healthcare professionals should determine whether further evaluation (e.g., otorhinolaryngology consultation) or discontinuation of Natesto is appropriate.
