Natesto Application

[Smokin Joe]

I know that Natesto is a Nasal application product but due to getting sores in my nose I've recently tried applying it on the inside of my biceps.
It seems to absorb well and I actually feel it better than the nasal application.
Just curious to know of anyone has tried this before?
Like all testosterone products the information says that he gel can transfer to others so the absorption makes sense.....

 

[Cataceous]

Most likely it is behaving like a typical transdermal product, albeit an expensive one. The problem is that dermal application greatly increases the half-life. When testosterone is not short-acting it suppresses the HPTA, costing you the primary advantage of a nasal gel.

 

[Smokin Joe]

Wow good information and I appreciate it!

 

[madman]

I know that Natesto is a Nasal application product but due to getting sores in my nose I've recently tried applying it on the inside of my biceps.
It seems to absorb well and I actually feel it better than the nasal application.
Just curious to know of anyone has tried this before?
Like all testosterone products the information says that he gel can transfer to others so the absorption makes sense.....

You are wasting your time here.

Natesto is meant to/needs to be applied intranasally in order to reap the benefits of the PK.

In and out of your system quickly due to the half-life of unesterified T.

Dosed 2-3 times daily which results in a short-lived peak with long trough times between doses.

The main reason one would choose Natesto over any other form of exogenous T is that it will cause the least suppression of the hpta out of all the T formulations.

Minimal testicular shrinkage and maintaining fertility without having to add in an ancillary like hCG to boot.

Minimal impact when it comes to side effects (cosmetic/blood markers), especially elevated hematocrit.

If you are dead set on transdermal application then you are far better off using a compounded T cream or big pharma gel.

Look over Figure 1 (PK) as this is the magic behind Natesto's minimal suppression of the hpta.

The key point here is a short-lived peak with long trough times between doses.



12.3. Pharmacokinetics

Absorption

Natesto delivers physiologic amounts of testosterone, producing circulating concentrations that approximate normal testosterone concentrations (i.e., 300 to 1,050 ng/dL) seen in healthy men. The maximum concentration for Natesto is achieved within approximately 40 minutes of administration and has a half-life ranging from 10 to 100 minutes.

Figure 1 summarizes the pharmacokinetic profiles of total testosterone in patients completing 90 days of Natesto treatment administered as 33 mg of testosterone daily (11 mg three times daily).

*Patients should be instructed to report any nasal symptoms or signs to their healthcare professional. In that circumstance, healthcare professionals should determine whether further evaluation (e.g., otorhinolaryngology consultation) or discontinuation of Natesto is appropriate.




5. WARNINGS AND PRECAUTIONS

5.1 Nasal Adverse Reactions and Limited Long-Term Information on Nasal Safety

Nasal adverse reactions, including nasopharyngitis, rhinorrhea, epistaxis, nasal discomfort, and nasal scabbing, were reported in the clinical trial experience with Natesto. All nasal adverse reactions except one (a single case of upper respiratory infection) were reported as mild or moderate in severity; however, long-term clinical trial data on nasal safety is available in a limited number of subjects [see Adverse Reactions (6.2)]. Patients should be instructed to report any nasal symptoms or signs to their healthcare professional. In that circumstance, healthcare professionals should determine whether further evaluation (e.g., otorhinolaryngology consultation) or discontinuation of Natesto is appropriate.

 

[ZALEMAX]

@madman, your post is spot on Natesto is for nasal use.

 

[Dfsoh]

I have always wondered about using Natesto with scrotal or rectal application.
Thoughts?

 

[Cataceous]

I have always wondered about using Natesto with scrotal or rectal application.
Thoughts?

I expect scrotal application would also extend the half-life and offer no advantage over a less expensive transdermal product. It seems possible that rectal application would preserve Natesto's short-acting behavior.

 

[Fortunate]

I expect scrotal application would also extend the half-life and offer no advantage over a less expensive transdermal product. It seems possible that rectal application would preserve Natesto's short-acting behavior.

Agree with this, but wow. That would not be pleasant...

 

[Smokin Joe]

Back on Natesto after a .month and a half break due to illness.
This time tbe acne on my back is horrible.
My wife who is a qualified popper says it's worse than when I was on injectable cipionate.
It itches like fire as well.
I'm going to stop again to see what happens.
Hate to stop and start but it doesn't seem to bother me.
Note:I am taking Cistanche 1/4 teaspoon a day as well but I doubt it is causing acne.
Any suggestions?

 

[Smokin Joe]

Not be ignorant about the types of testosterone but Natesto applied 3 times a day at 33mg x 7 days = 231mg of testosterone weekly.
I'm normally prescribed 100mg weekly of injectable Cipionate.
Could the difference be the cause of this insane back acne?
Is the absorbability a factor with Natesto?
Any help appreciated.

 

[Fortunate]

Not be ignorant about the types of testosterone but Natesto applied 3 times a day at 33mg x 7 days = 231mg of testosterone weekly.
I'm normally prescribed 100mg weekly of injectable Cipionate.
Could the difference be the cause of this insane back acne?
Is the absorbability a factor with Natesto?
Any help appreciated.

My guess is that it's the sharp fluctuations at play? Three quick peaks a day. Natesto does not really bump DHT or E2 much at all.

 

[Smokin Joe]

Hey thanks for the reply.
I have not had any side-effects such as shrunken testicals or tight scrotum like I get with injections .
Just the severe acne.
Maybe I'll try every other day?
I'm now taking Cialis 5mg daily with the Natesto.
My sex drive is increasing from low to moderate. Still taking cistanche once daily as well.
I'll experiment with it and see if I can get the acne under control without losing the goody out of it.