Nelson, can you address the value of having low SHBG, without pre or definite diabetes? I can't understand how it would make someone feel bad, even with high E levels, assuming one also has high free T and likely high total T? My SHBg is 21 (on the low end) but my total T is very high at 1983 ng/dl and free T at 698 pg/ml. My estrodial on Quest ultra sensitive at 336 pgml. I have no adverse symptoms, of anything, my hematocrit and hemoglobin are barely above high end of normal, (17.7 and 53) (so I just gave blood a few days ago and these numbers have been steady for months) and the rest of my labs are normal. LDL is 56, and my HDL (which has always been low and unchanged since starting T is 35. While I feel great, I am concerned, about such a high T level. Why did we drive T so high? Because every time I went up in dose, the labs really didn't change much and I felt better and got more and more help with ED, libido, and other symptoms. I am on the topical cream 1 gram (with 200mcg of T) BID. So for those who don't think you can get lots of T with an easy to use cream base product....I am walking proof. My question about SHBG is so what if its low with no diabetes? I do have a little oily skin but thats it!