AbsoluteZ3R0
Member
I see this is an old thread.... but anyway, have been looking at Toremifene.... this study:
https://www.ncbi.nlm.nih.gov/pubmed/17412336
RESULT(S):
Toremifene administration resulted in a significant increase in FSH, testosterone, SHBG, and inhibin B levels, as well as in sperm concentration, percentage motility and normal sperm forms.
As far as I know, all SERMs raise SHBG. I believe this is due to the E2-agonizing qualities they exhibit on specific receptors. Of course, the issue with SERMs is that the varying interactions they exhibit on E2 receptors can often make their effects unpredictable. I would imagine that using any of them effectively in conjunction with a standard TRT protocol would be disastrously convoluted. The most commonly used one is tamoxifen, but only temporarily to combat gynecomastia. I can't imagine staying on a SERM throughout the entirety of a trt regimen, and I would imagine that SHBG would return to baseline after discontinuation. Incidentally, I used clomid for a few months and my SHBG didn't budge (it was actually a few decimals lower on clomid than it was pre-clomid, not a significant difference).