Nicotine use via snus, or what is getting more common nicotine bags without tobacco, absolutely are addictive, even though there is no smoking involved and the delivery is sustained...so i will argue nicotine will always be addictive, and will always be vasoconstrictive, have personally experienced declining erection quality that subsided when quitting buccal use, personally know many who have had circulation problems. That being said it is an immunosuppressant and may be beneficial for some, especially if very low doses provide benefits, one would assume that 1-2mg in 24h period would not be that bad for the CV system.
As a parasympathetic alkaloid and the main substance in cigarette smoke, nicotine modulates the immune system, inhibits innate and acquired immunity and is used in treating many autoimmune diseases. It often stimulates the α7 receptor and causes an ...
www.ncbi.nlm.nih.gov