Gianluca
Well-Known Member
@Gman86 not offense taken at all here, we are all trying to learn what is best to do.No offense to @Gianluca. I love all the experimenting ur doing on the subject, and how methodical u are with everything, and how interested u are in things like prog and preg, in regards to optimizing one’s protocol. I’m sure u understand what I was saying above
However, I do want to correct one of your statements, as Progesterone cream on the scrotum has given me constantly the same blood level. Two hours after application I'm at .6 ng/ml, and about 6/7 hours later I'm at .5. I have been doing it since January and checked levels a few times. On the other hand, forearm and inner thigh application was a disaster.
You sound you have been paying more attention than me, to Progesterone cream side effects vs injection. We know that in the skin, there are certain enzymes, and perhaps Progesterone encountering these enzymes may cause some unwanted side effects.
When I was applying the cream on my forearm, I thought I would feel almost drugged or in hangover almost dizzy. On scrotum, some time I may feel forgetful, or I could sleep at anytime during the day but also not, weird. I have seen other guys experiencing the same. But these symptoms improved significantly when adding back Pregnenolone cream. Curios if you or @Cataceous have ever experienced these side effects with the injection?
As we discussed yesterday, the only really major side effect now for me, is a possible effect on E2 receptors due to Progesterone as you suggested (I haven't checked the literature on this), making my joint to pop and crack, even if my E2 came back up nicely. If Progesterone induces this downregulation of E2 receptor, I doubt the injection route will change anything with this side effect, if this is the problem. I'm not trying to defend the cream, I'm actually open to try injection and see how it goes. I may decide between the injection route or just adding a 25mg Pregnenolone cap to raise Progest, see how that goes.