While we await BigTex's thoughts, a couple of things...1) All the other usual-suspect anti-inflammatories appear, from what I have been able to determine, to have downsides which prevent healthy chronic use. Aspirin can cause bleeding. NSAIDS like ibuprofen don't appear to be heart-healthy and have other issues I have forgotten the details of but which Chris Masterjohn has highlighted. 2) As I posted in another thread, I have been having success with White Willow Bark but I have only been using it a short period of time (a month or so), it is not as "strong" as other compounds, and it may have other issues I have not discovered yet such as interference with enzymes. 3) There was a post on another board that made the case that water retention in the joints was the mechanism behind the joint relief, and "dry" compounds such as Winstrol which tend to increase joint pain were cited as part of the argument. 4) I don't have a strong view on what the mechanism is, however if the affect was predominantly one of blocking pain signals, then people who use Nandrolone for joint relief and then go off of it should logically have much worse pain and joint damage when they stop since they blocked the pain warning signal, however I have not seen reports of this. Also, if tendon pain is blocked and someone continues to work the tendons before they heal, a phenomenon called tendinosis can occur which makes the tendon very prone to rupture, so we should hear of numerous tendon tears from people on Nandrolone, however we don't.