If you're talking about daily injections then 10 mg TC/TE is relatively safe, matching the average daily production of healthy young men, ~6-7 mg T. In my opinion 20 mg TC/TE per day is excessive, to the point of not being TRT. Even 10 mg per day is in theory too much for about half of all men—because it exceeds their prime natural production. You should be prepared to titrate downwards if any symptoms of excess arise.What would be a "safe" low dose starting point for someone who has hypertension and past clotting issues, both of which are being managed by meds, exercise, diet? 20mg?
Due to my existing hypertension and past hypercoagulopathy, perhaps I would be best advised to try a SERM (i.e. enclomiphene) before jumping to frank TRT. Thoughts?If you're talking about daily injections then 10 mg TC/TE is relatively safe, matching the average daily production of healthy young men, ~6-7 mg T. In my opinion 20 mg TC/TE per day is excessive, to the point of not being TRT. Even 10 mg per day is in theory too much for about half of all men—because it exceeds their prime natural production. You should be prepared to titrate downwards if any symptoms of excess arise.
10mg TE /day brings me 9,25 ng/ml. The normal range here in Germany is 2,41-8,30 at least on my report. While writing this... I took 0,75mg Finasteride with it maybe it would be lower without the supressed DHT conversion. But even 15% less would be on the upper end of normal. And this all the time.If you're talking about daily injections then 10 mg TC/TE is relatively safe, matching the average daily production of healthy young men, ~6-7 mg T. In my opinion 20 mg TC/TE per day is excessive, to the point of not being TRT. Even 10 mg per day is in theory too much for about half of all men—because it exceeds their prime natural production. You should be prepared to titrate downwards if any symptoms of excess arise.
The million dollar question is can we compare natural levels of T production to what we supplement. I spoke with Dr Rand McLean recently and he said the level of T we measure when not on TRT is not the same as to when we are on TRT , he said we need higher levels on TRT , haven’t heard that before though.10mg TE /day brings me 9,25 ng/ml. The normal range here in Germany is 2,41-8,30 at least on my report. While writing this... I took 0,75mg Finasteride with it maybe it would be lower without the supressed DHT conversion. But even 15% less would be on the upper end of normal. And this all the time.
Some years ago I felt good on 20mg/day. Was total off last summer to see what happens for 12 weeks. The only downside I feel is a lack of drive and motivation. I feel in a way old when I am off.
Need it for what?we are on TRT , he said we need higher levels on TRT
SERMs are kind of unpredictable. I think short-acting testosterone would be a better bet. These include nasal gels and troches. These products do not result in complete HTPA suppression, so you can have an additive effect with your natural testosterone production. Read about Natesto, for example.Due to my existing hypertension and past hypercoagulopathy, perhaps I would be best advised to try a SERM (i.e. enclomiphene) before jumping to frank TRT. Thoughts?
To feel optimisedNeed it for what?
That is what I thought "what" may be referring to. See my additional comments above. Guys, feel free to add on. I have not found that wonderful free lunch. Great if you do. Nota Bene.To feel optimised
That feeling of optimization comes at a high cost. After reading hundreds of posts here on side effects, I can tell you that 90% or more were due to T dose being too high. It almost always catches up to you eventually.To feel optimised
If you're talking about daily injections then 10 mg TC/TE is relatively safe
Need it for what?
Anabolic drive...check.
Bigger more vascular muscles...yep.
Less sleep and interrupted sleep...ouch.
Diminished cognitive function....whoops.
Intermittent ED and alternating bouts of raging libido...that's a doozy.
If susceptible, elevated Hct and BP/RHR/WB viscosity...could be good or bad depending on your baseline.
Long term cardiovascular implications for at individual level...not a clue.
Disclose objective function when clarifying what is needed or using this term optimization.
I wouldnt say thats optimised, optimised to me is feeling right and having everything in range, obviously taking too much isnt optimisedNeed it for what?
Anabolic drive...check.
Bigger more vascular muscles...yep.
Less sleep and interrupted sleep...ouch.
Diminished cognitive function....whoops.
Intermittent ED and alternating bouts of raging libido...that's a doozy.
If susceptible, elevated Hct and BP/RHR/WB viscosity...could be good or bad depending on your baseline.
Long term cardiovascular implications at individual level...not a clue.
Disclose objective function when clarifying what is needed or using this term optimization.
The word expert gets used quite a lot today. I don't hear the term competent nearly as much.
I don't know. To each their own and I like your honesty. Definitely should be a legal easy way to play your hobby just like food, booze, cigs and other. Ridiculous hoops that anabolic enthusiasts have to jump through or take completely asymmetric risk to reward to go cheaper UGL route. Dumb.guess what I really need is a shrink and not Testosterone. My self-esteem needs to come from elsewhere.
I have a friend who's been on clomid and adex for several years and his T land E2 labs look great and he feels great. I just don't like the possible estrogenic aspect, but that hasn't seemed to be a problem for him, so, was thinking of giving enclomiphene a shot.SERMs are kind of unpredictable. I think short-acting testosterone would be a better bet. These include nasal gels and troches. These products do not result in complete HTPA suppression, so you can have an additive effect with your natural testosterone production. Read about Natesto, for example.
Due to life circumstances, I've been missing 1 daily shot per week. Back when I did twice per week, getting off by a day never seemed to matter. Is this likely the case with daily shots, as long as it's only one shot missed?SERMs are kind of unpredictable. I think short-acting testosterone would be a better bet. These include nasal gels and troches. These products do not result in complete HTPA suppression, so you can have an additive effect with your natural testosterone production. Read about Natesto, for example.
If I did TE, I would be comfortable with microdosing daily subq injections. But would it suppress HPTA more than other delivery systems?
Yes, this is going to be similar. With long-acting esters the minor dip in testosterone from missing a day probably isn't perceptible.Due to life circumstances, I've been missing 1 daily shot per week. Back when I did twice per week, getting off by a day never seemed to matter. Is this likely the case with daily shots, as long as it's only one shot missed?
It applies to primary hypogonadism as well. Primary has the advantage of a normal body set point for its testosterone level—the testicles just can't produce enough to reach that level. For example, the hypothalamus and pituitary want total testosterone to be 650 ng/dL, but the testicles only produce enough to give you 200 ng/dL. With TRT you can dose to get close to the desired level without seeing HPTA shutdown—you're not exceeding what the hypothalamus and pituitary are calling for....
This applies to secondary hypogonadism. As @Cataceous has mentioned in other threads, primary may be a different story.
There's probably no harm in giving it a try. You might do well with it. My suspicion is that enclomiphene is more likely to give good results in those who naturally produce more estradiol. I'm in that category. It makes me wonder if guys with lower aromatization could actually do better with Clomid, where you're basically adding estrogen to your enclomiphene.I have a friend who's been on clomid and adex for several years and his T land E2 labs look great and he feels great. I just don't like the possible estrogenic aspect, but that hasn't seemed to be a problem for him, so, was thinking of giving enclomiphene a shot.
...
I think it would be worth trying short-acting testosterone, such as nasal gel or troches. You might be able to get the benefits of testosterone without the problems. These products would also allow your HPTA to function normally....
Everything gets better when I am off. Recover faster from training, sleep better, able to increase the load with no impact on HRV.
There are two downsides of being off: Total loss of libido (expected) and with it a loss of drive in general. I get slow and unmotivated. I was not long enough off to see a change in body composition. I am aware that it will happen long term, I will lose bone density as well and my better recovery might be only transient. It is hard to find a way out.
...