shbg

I'm around 700 natural T due to high shbg-60ish, and e2 is low 16-19. Would a low dose of T cyp keep me from shutting down my natural T? My thinking is that the extra T would push down shbg, then e2 might slowly increase to mid 20s without a shutdown. I have been experimenting with T and had a...

Guys that have low SHBG, what protocols have you used and what is your SHBG? I’m a low SHBG guy myself (11) prior to starting TRT and have tried ED @20mg and it still put my free over the top and E2 out of control. Just thought we could all share in one post what all we’ve tried and the results.

When I started trt my SHBG was 51 on a range of 19.3-76.4. My trough T has settled around 850-900 with a free T of 28-33. One peculiar thing is while my T has stabilized at a consistent place, SHBG keeps dropping. My last 3 labs were 37, 32, now 28. While trough total T was 876, 842, 883...

Hi, How many of you guys noticted lowered SHBG after starting TRT? I am most curious about people who had high-ish SHBG before taking testosterone. For me the drop was almost 50%.

I am high shbg, consistently over 55-65 (range 15-55) I am currently on 40 mg test 2x per week and 360 iu hcg 3x per week. I am getting very inconsistent sleep and feeling up/down throughout the week. I know high shbg typically go with larger, single injections but I’m worried that even more...

My SHBG is on the lower side at around 25. Total T is 650 trough days and E2 around 45. I currently inject 50mg test C two times a week (Tuesdays and Fridays) It has been mentioned on here in the past that I may benefit from an EOD schedule due to my low-normal SHBG. How do I calculate the...

I only seem to get libido and good/random erections during a protocol change, I have reduced my dosage several times and each time I get good libido in week 2 or 3 and then it dissapears. I am a daily low shbg injector. Has anyone dealt with this and how did you rectify it? Theory #1. it was...

Hello everyone. I was on trt for a few years and came off to try and have kids. We have one on the way, so I'm weighing my options and thinking about going back on. Labs from a few months ago: Labcorp Total T 570 246 - 916 ng/dl Free T 7.3 8.7 -...

I have many of the same issues that I see here everyday, not great energy, low libido but its better than before trt. I've been on injectables for 2 years. My current weekly protocol is 100mg T, split SubQ twice per week and 500 iu HCG twice a week. I just got my labs back and have a consult...

When I first started TRT around 10 months ago, my SHBG was around 21. Due to this, many on these forums recommended doing EOD injections, which is what I have been doing. I have noticed that over these past 10 months, my SHBG has been increasing slightly, with it being 30 on my most recent blood...

I am making the switch from cream to injectable T cypionate. I started with cream because I thought it would be more convenient; however, I’ve become convinced it is actually less convenient, as you have to wait for it to dry and plan shower/swim/workout/sex times around it (two times a day, at...

For those with either NAFLD/NASH or high lipids (trigylcerides, ldl, etc), a drug called mgl-3196 by Madrigal Pharm. just concluded its phase 2 trial and patients had an average of their SHBG increasing 80% from baseline with some over 100%. Drug also statistically significantly lowered...

I've just discovered that SHBG levels will determine what injection frequency is best for the individual. My last two SHBG tests were 36 and 42, range 18 - 57 nmol/L Are these considered high, optimal, or low?

I have a low SHBG (14.4 last lab). Since measuring my SHBG (even before i started trt) it has always been between 14 and 18. I have used a lot of protocols the past 3 years with sustanon: once a week 125 mg, 150 mg 250 mg (no effect, no weightgain, no nothing. Even on 250 mg for 6 weeks what...

Why does a low Free T % cause symptoms? I calculate 2 profiles. A guy with 600 total T and shbg at 30, and a guy with 800 total T with shbg at 50. Using an online free T calculator, guy 1 has a 2.30% free T and guy 2 has a 1.75%. Both will have similar direct free T numbers of 14 ng/dl. But...

So as I mentioned in another thread, my endo prescribed sustanon-250 once every two weeks, with review after three shots (labs taken day before third shot). I am aware of the T-level fluctuation related issues with high-dose low-frequency injections (half-lives and all that) but my problem isn't...

J Urol. 2017 May;197(5):1326-1331. doi: 10.1016/j.juro.2017.01.018. Epub 2017 Jan 10. The Utility of Sex Hormone-Binding Globulin in Hypogonadism and Infertile Males. Ring J1, Welliver C2, Parenteau M3, Markwell S1, Brannigan RE4, Köhler TS5. Abstract PURPOSE: We sought to determine the role...

Hi guys, I'm strongly considering injecting myself 3x per week rather than the 2x per week I have been doing. The doctor suggested I might have some success with it as well. I currently inject only my HCG 3x per week. My SHGB is 21, would I inject M/W/F? How would I feel on Saturday and Sunday...

After realizing that after 8-9 yrs of being on TRT that I have been using way too much Test for my body... I have been injecting anywhere from 170-220mg per wk, started at 2xWK, then EOD, now ED, from IM to SQ..... my levels have always been top 80% of TT range and top 90-120% of FT range, low...

High IGF1, Low HDL, Low SHBG, but normal Blood glucose and A1C. Fit and not overweight at all. Thyroids are all good, no fatty liver Would you say there's a possibility that I suffer from mild insulin resistance? What other tests are out there to confirm this? It's been years and I'm still...

My shbg has come up at 23 and 25 on separate tests. I'd like to inject as infrequently as possible while still being stable. How often should I be injecting? Is every 3 days ok for my T and HCG?

Gentlemen, I'm glad I found this group there's been a lot to learn so far and the forum has been an informative resource. Here's my story. I'm 43 and have I've been on TRT for around 1.5 years and have not had much success in consistently getting the erections I had Pre-TRT. My libido is...

Guys, Labs below. I’m new to the cite but looking for some help. I am currently on week 2 of TRT. I battled with this decision for several years. 3 years ago I had a TT of 359 at age 33. Now 36, I had my labs done and I’m at 602 but my free test is at 13. My SHBG is also high and estradiol on...

I searched the forums but could not find the answer. For those of you who have increased injection frequency, have you seen an increase in SGBH? Does changing injection frequency have any impact on SHBG? Thanks

Hi All. Me going to start this week on Friday with Testosterone Only I am Primary and want achieve Optimal Test Levels My details Age 41 Weight 75/77 kg Height 175cms TT 378 Shbg 50 Estradiol 38 Should I start with 100 MG splitting in a week and after 6 weeks after blood work ramp up dosage Does...

Hi all, I’m in the process of scheduling a consultation with Defy but also wanted to visit a Urologist in-person for a consultation to discuss TRT and some post vasectomy pain. I have an upcoming appointment with Dr. Melograna from MidAtlantic Urology. Other members have posted about him on...

Good afternoon, After doing more research and reviewing the responses to my other thread, I’ve decided to schedule an appointment with Defy to get a consultation and potentially start a TRT protocol to treat my low free testosterone. I looked back at my lab history over the past 2 years and I...

Trying to not make a wall of text here as it's really not that interesting. I've been living in basically hell for the last 10 years and need to get to the bottom of this before I off myself. (Joking, but not really somedays it feels). (Back story) 34 now, married one child. Have had low T...

Hi all, I’ve been treating hypothyroidism over the last 2.5 years and finally after multiple medications and doses i’ve found what works well for me. I take a combination of unithyroid and cytomel along with some iodine. Unfortunately, since I started my treatment, my SHBG has been...

Does anyone feel like anatrozole affects their memory recall and cognitive abilities? I have been on daily shots with .25mg of adex daily for a few months now and am having ED, issues learning things, and articulating myself. Not sure if I just bottomed out my E or if it might be a side effect...

Long-term weight loss maintenance, sex steroid hormones, and sex hormone-binding globulin. Duggan C1, Tapsoba JD1, Stanczyk F2, Wang CY1, Schubert KF3, McTiernan A1,3,4. Author information Abstract OBJECTIVE: We tested the effects of weight loss on serum estradiol, estrone, testosterone, and...