REALLY Struggling With Weight Loss: What Labs to Run?

Hi y'all,

for a bit more of my background (optional) I have a thread here about being on HCG Monotherapy for many, many years: Long-Term HCG Monotherapy Results and that'll go into some specific blood work.

But here's the situation.

I have kept 100lbs off for over a decade and cannot get the last little bit off - all of the weight is concentrated in my stomach. I've tried every possible diet and my body usually adjusts rapidly with all the lost weight coming back after a few weeks (ie, I did IF/keto at a deficit and dropped 10lbs in two months, and then by month three of that diet, with no changes to caloric intake, it had all come back).

I weigh all of my food and track all of my calories meticulously. All of it. If I put two tablespoons of whole milk in my coffee, it gets logged. Splash of cooking oil in my stir-fry? Logged. Believe me when I tell you I know exactly how many calories I am eating. I also have a very "clean" diet. Yesterday's eating, for example, was as follows; Breakfast - oatmeal, fresh fruit and some almonds, protein shake. Lunch - grilled chicken thighs, stir-fried vegetables, steamed rice. Dinner - lean flank steak, black beans, brown rice, steamed veggies. Dessert - a very small bowl of dark chocolate granola with some whole milk. I drink plenty of water. That's an average day for me, though on Friday or Saturday night I may have 1-2 beers and a slightly larger untracked meal (ie, going out to dinner with friends, but not going totally nuts and eating a large pizza by myself).

I otherwise don't drink, nor do I use any recreational drugs.

I am physically active, doing at least 30 minutes of Zone 2 cardio 4-5 times per week and lifting weights at least three times per week. I do not have any trouble gaining muscle in the gym.

I have gotten my metabolism clinically checked in a hospital setting, which showed my RMR to be 2350 calories per day. Working with a nutritionist, we set that as my "floor" for my caloric intake and I started eating 2450 calories per day, at which point I started gaining one pound per week despite being ravenously hungry. We also did a body fat check via skin fold, later independently confirmed by BodPod scan - my arms, legs, upper back, and shoulders were all in the single digits or close to it (8% to 10%) but my upper chest/pec area was 28% body fat and my abdomen was 44%. The doctor said he had never seen anything like it and that usually the variance is at most 10% between body parts.

The following blood values have all been tested and are within normal ranges: T3, T4, TSH, Free/Total Testosterone, Estrogen, Cortisol, A1C, fasting and un-fasted blood glucose, full liver and kidney panels.

I am currently taking three prescription medications: HCG monotherapy for low T as indicated, 350iu subcutaneously per day. Trintellix for depression, 10mg per day. Vyvanse for ADD, 20mg per day.

So, my thought here is that something chemical is going on. To support this hypothesis I will note that about two years ago I took compounded semaglutide for a few months before losing my job and having to quit for financial reasons. With with no other lifestyle changes I lost ten pounds in two months, and this weight has not come back. I'm not opposed to going the GLP-1 route again, but I am worried that my symptoms are indicative of a larger issue.

Are there other labs I should be looking at? I'm just totally stumped here.

Cheers!
 
My first thought was cortisol, but it looks like you've tested that. You might want to check your insulin levels and make sure fasting insulin is under 6 or so. You might also want to work with a holistic doc and test for chronic infections like mold exposure. I know people who have had very good results with intermittent calorie restriction where you eat at maintenance or slightly above for 4 days and eat around 70% of that the other three days (interspersed, not 3 days straight.) Walking has often made me noticeably leaner and many people do what they think is zone two but which is actually more than that.
 
Hi y'all,

for a bit more of my background (optional) I have a thread here about being on HCG Monotherapy for many, many years: Long-Term HCG Monotherapy Results and that'll go into some specific blood work.

But here's the situation.

I have kept 100lbs off for over a decade and cannot get the last little bit off - all of the weight is concentrated in my stomach. I've tried every possible diet and my body usually adjusts rapidly with all the lost weight coming back after a few weeks (ie, I did IF/keto at a deficit and dropped 10lbs in two months, and then by month three of that diet, with no changes to caloric intake, it had all come back).

I weigh all of my food and track all of my calories meticulously. All of it. If I put two tablespoons of whole milk in my coffee, it gets logged. Splash of cooking oil in my stir-fry? Logged. Believe me when I tell you I know exactly how many calories I am eating. I also have a very "clean" diet. Yesterday's eating, for example, was as follows; Breakfast - oatmeal, fresh fruit and some almonds, protein shake. Lunch - grilled chicken thighs, stir-fried vegetables, steamed rice. Dinner - lean flank steak, black beans, brown rice, steamed veggies. Dessert - a very small bowl of dark chocolate granola with some whole milk. I drink plenty of water. That's an average day for me, though on Friday or Saturday night I may have 1-2 beers and a slightly larger untracked meal (ie, going out to dinner with friends, but not going totally nuts and eating a large pizza by myself).

I otherwise don't drink, nor do I use any recreational drugs.

I am physically active, doing at least 30 minutes of Zone 2 cardio 4-5 times per week and lifting weights at least three times per week. I do not have any trouble gaining muscle in the gym.

I have gotten my metabolism clinically checked in a hospital setting, which showed my RMR to be 2350 calories per day. Working with a nutritionist, we set that as my "floor" for my caloric intake and I started eating 2450 calories per day, at which point I started gaining one pound per week despite being ravenously hungry. We also did a body fat check via skin fold, later independently confirmed by BodPod scan - my arms, legs, upper back, and shoulders were all in the single digits or close to it (8% to 10%) but my upper chest/pec area was 28% body fat and my abdomen was 44%. The doctor said he had never seen anything like it and that usually the variance is at most 10% between body parts.

The following blood values have all been tested and are within normal ranges: T3, T4, TSH, Free/Total Testosterone, Estrogen, Cortisol, A1C, fasting and un-fasted blood glucose, full liver and kidney panels.

I am currently taking three prescription medications: HCG monotherapy for low T as indicated, 350iu subcutaneously per day. Trintellix for depression, 10mg per day. Vyvanse for ADD, 20mg per day.

So, my thought here is that something chemical is going on. To support this hypothesis I will note that about two years ago I took compounded semaglutide for a few months before losing my job and having to quit for financial reasons. With with no other lifestyle changes I lost ten pounds in two months, and this weight has not come back. I'm not opposed to going the GLP-1 route again, but I am worried that my symptoms are indicative of a larger issue.

Are there other labs I should be looking at? I'm just totally stumped here.

Cheers!
Try adding some HIT training. As this will not burn more fat by itself BUT make your mitochondria MORE efficient at fat burning when you are in fat burning mode.
 
Try adding some HIT training. As this will not burn more fat by itself BUT make your mitochondria MORE efficient at fat burning when you are in fat burning mode.
I agree with this, but with the caveat that you don't want to put yourself into a state of overtraining. I would slightly cut back on something else and, to start, add one BRIEF workout per week of either sled-pushing or sprints on a slightly uphill slope. Total workout time should be no more than 15 minutes including rest breaks.
 
Strange that you didn't regain the weight lost after discontinuation of GLP-1.
Not sure if the psychiatric meds or the HCG could contribute to this fat distribution pattern.
I believe it's not unusual, isn't sometimes called skinny fat.
 
I started keto 3 weeks ago and I use a breath meter to verify. My fat storage area is the same as yours, lower abdomen. I am shocked by how much of it has melted away in just three weeks.
 
Your best bet is Semaglutide, to lessen your appetite and calories, because clearly that's where the problem is. You will not understand how your body works at 100% - contemporary medicine is not that advanced and you already checked all of its tests.

If you start losing your fat, but you still have a lot of visceral fat in the abdomen, then you may conclude that there is some deeper underlying problem. What this or that doctor said doesn't matter - they are typically clueless. Most aging people collect fat around the abdomen with normal blood tests.

Vyvance is a stimulant and theoretically I would expect it to lessen appetite but that doesn't seem to be happening in your case. You could try to replace it with Phentermine, which is prescribed for appetite suppression.

Also, I don't understand why you need Trintellix, when the stimulant should be able to displace the depression by itself. Fewer pills, fewer side effects.
 
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Your best bet is Semaglutide, to lessen your appetite and calories, because clearly that's where the problem is. You will not understand how your body works at 100% - contemporary medicine is not that advanced and you already checked all of its tests.

If you start losing your fat, but you still have a lot of visceral fat in the abdomen, then you may conclude that there is some deeper underlying problem. What this or that doctor said doesn't matter - they are typically clueless. Most aging people collect fat around the abdomen with normal blood tests.

Vyvance is a stimulant and theoretically I would expect it to lessen appetite but that doesn't seem to be happening in your case. You could try to replace it with Phentermine, which is prescribed for appetite suppression.

Also, I don't understand why you need Trintellix, when the stimulant should be able to displace the depression by itself. Fewer pills, fewer side effects.
First hand experience, stimulants have a way of lessening appetite at first but that goes away after awhile. Also, and this goes for phentermine, there's a rebound weight gain to that stuff. Semaglutide is a better bet but then again not everybody can achieve zero percent body fat before our bodies in the ground.
 
Thanks for the insights, y'all. I have taken @Guided_by_Voices' suggestion and booked an appointment with a well-regarded and highly-recommended holistic/functional medicine doctor in town who specializes in weight loss and hormone issues. I'd just like to make sure there isn't an underlying issue before I throw more drugs at the problem (GLP-1 or otherwise), especially since I'm at single digit body fat (or near it) everywhere except my torso. If everything's all clear then I've got no problem hopping back on a GLP-1 or something else, since, again, I didn't regain any of the weight I lost last time around.

It's possible that it could be related to my medication, but weight gain is not an observed side effect of anything I take in any clinical trials, nor do I take particularly high doses of anything (10mg is the lowest dose of trintellix, 20mg is the second-lowest dose of vyvanse, etc). It's also not something I really have any control over as going off any of my medications causes pretty significant problems for my mental and physical health and I've spent a long time dialing in a regimen that works for me without any observable side effects.
 

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