Semaglutide Forum: Game Changer for Weight Loss

[Deleted member 43589]

Lets face it.....the history of weight loss drugs has been horrible.

Factbox: A troubled history for weight-loss drugs

A proposed diet drug from Orexigen Therapeutics was rejected by U.S. regulators who requested a clinical trial to resolve concerns about heart risk, the company said on Tuesday.

www.reuters.com

Lets just go ahead and throw 2,4-Dinitrophenol into the mix. It is still being used.

2,4-Dinitrophenol (DNP): A Weight Loss Agent with Significant Acute Toxicity and Risk of Death - PMC

2,4-Dinitrophenol (DNP) is reported to cause rapid loss of weight, but unfortunately is associated with an unacceptably high rate of significant adverse effects. DNP is sold mostly over the internet under a number of different names as a weight ...

www.ncbi.nlm.nih.gov

 

[tareload]

Lets face it.....the history of weight loss drugs has been horrible.

Factbox: A troubled history for weight-loss drugs

A proposed diet drug from Orexigen Therapeutics was rejected by U.S. regulators who requested a clinical trial to resolve concerns about heart risk, the company said on Tuesday.

www.reuters.com

Lets just go ahead and throw 2,4-Dinitrophenol into the mix. It is still being used.

2,4-Dinitrophenol (DNP): A Weight Loss Agent with Significant Acute Toxicity and Risk of Death - PMC

2,4-Dinitrophenol (DNP) is reported to cause rapid loss of weight, but unfortunately is associated with an unacceptably high rate of significant adverse effects. DNP is sold mostly over the internet under a number of different names as a weight ...

www.ncbi.nlm.nih.gov

I'm sure if Pharma could find a way to sustainably manage the side effects DNP would be selling like hot cakes.

 

[Deleted member 43589]

It sells pretty well in the black market (weight loss of up to 1.5 kg per week is reported without significant side effects"....Here is another one that is still very much available....Sibutramine (Reductil™ Abbott Laboratories) and phentermine....which seems to be being replaced by Semaglutide.

 

[tareload]

10 years ago I was 320 lb and >35% BF. Took about 1 year to drop 100 pounds and of course another few years to do a proper body recomp. Add in TRT in 2018 and now I sit at about 240 lb and 8-10% BF. This is a marathon not a sprint. These obesity pharma interventions will end in tears. Take the time to find what works for you and your body. In my case it is low carb and either full blown keto (Phase 1 fat loss) or higher protein medium fat (Phase 2 muscle gain while maintaining low BF). Lots of veggies. Yes to the mainstream I am now looked at as having the eating disorder. That's how screwed up our food system is now.

Good luck.

 

[tareload]

So I was on Wegovy (Semaglutide) for about 1 year, lost 35 lbs. The initial side effects were a pain but manageable. I titrated up to the max 2.4 dosage. My issue became elevated heart rate and PVC’s (Skipped heart beats). I stopped in December at the recommendation of my cardiologist and they went away completely. We are talking like 20 beats per minute increase in resting heart rate.

Anyone else experience these heart related side effects? The medicine is a miracle. Cuts appetite and cravings in an unbelievable way. I want to try Mounjaro (different formulation) but concerned because it’s still a GLP -1 agonist.



Would love to hear if anyone else had or solved these issues?

Effects of GLP-1 Receptor Agonists on Heart Rate and the Autonomic Nervous System Using Holter Electrocardiography and Power Spectrum Analysis of Heart Rate Variability

Long- and short-acting glucagon-like peptide 1 receptor agonists (GLP-1RAs) liraglutide and lixisenatide, which are available for diabetes therapy, may act

diabetesjournals.org

Thanks for sharing your experience. I will take a hard pass. Imagine guy already overdoing it on TOT and then adding in the GLP1 agonist. Sounds like a ride I don't want to get on.

 

[Deleted member 43589]

About 15 months shown here. No GLP-1 agonist involved.

Shoot for waist to height ratio under 0.5.

View attachment 29099

This would be Phase 1 of the Body Recomp...fat loss (and muscle loss) Phase.

By the way, congratulation on your loss!

 

[pyater]

Effects of GLP-1 Receptor Agonists on Heart Rate and the Autonomic Nervous System Using Holter Electrocardiography and Power Spectrum Analysis of Heart Rate Variability

Long- and short-acting glucagon-like peptide 1 receptor agonists (GLP-1RAs) liraglutide and lixisenatide, which are available for diabetes therapy, may act

diabetesjournals.org

Thanks for sharing your experience. I will take a hard pass. Imagine guy already overdoing it on TOT and then adding in the GLP1 agonist. Sounds like a ride I don't want to get on.

View attachment 29102

@readalot - Thanks for posting the study. I will share with my Endo. He actually looked up while I was in the office. Heart side effects of semaglutude and all he said was very rare.

 

[SteveCleves]

Effects of GLP-1 Receptor Agonists on Heart Rate and the Autonomic Nervous System Using Holter Electrocardiography and Power Spectrum Analysis of Heart Rate Variability

Long- and short-acting glucagon-like peptide 1 receptor agonists (GLP-1RAs) liraglutide and lixisenatide, which are available for diabetes therapy, may act

diabetesjournals.org

Thanks for sharing your experience. I will take a hard pass. Imagine guy already overdoing it on TOT and then adding in the GLP1 agonist. Sounds like a ride I don't want to get on.

View attachment 29102

Just my experience. 2 years of Semaglutide @ 1mg a week. RHR at start was 68, currently 58.

Also liraglutide from that study is a daily injection.

 

[captain]

All the things people been doing on here over the years and your talking about side effects from semaglutude. Starting to sound like Jillian Michaels.

 

[tareload]

and your talking about side effects from semaglutude

So what would be the plan....stay on GLP-1 agonist indefinitely?

 

[captain]

Till something better comes along I would use it. I would say if it's not working for you, it would be best to stop.

 

[Vtail]

So what would be the plan....stay on GLP-1 agonist indefinitely?

My wife has been taking Semaglutide for a few months and is down about 25-30 lbs without any of the unpleasant gastric side effects. Her doc told her that when she reaches her target weight that she would be switched to a maintenance dose. I don't know whether that means the same dosage less frequently or a lower weekly dosage, nor do we know what will be recommended for overall duration. But it sounds like her doctor is leaning towards "indefinitely".

 

[bixt]

10 years ago I was 320 lb and >35% BF. Took about 1 year to drop 100 pounds and of course another few years to do a proper body recomp. Add in TRT in 2018 and now I sit at about 240 lb and 8-10% BF.

Well done! Current pics?

 

[tareload]

Well done! Current pics?

Look like last pic today (a little leaner):

5 Months in...

My carb intake generally comes from oats, sourdough on occasion, berries, dark leafy greens, steamed white rice, 4oz of orange juice once a day with psyllium husk, and carb balance tortillas (going to be doing away with these, lots of unnecessary ingredients.) I also try to time my largest...

www.excelmale.com

Will delete later as I don't like these floating out there for long. But if it helps encourage and avoid disappointment with GLP-1 agonist then I will take a little risk.


Did it in two Phases:

5 Months in...

Hello All, My name is Steve. I started TRT about 5 months ago and am trying to wrap my head around what my most recent blood testing results are telling me. First of all I am 33, have struggled with my weight for most of my adult life. I would be categorized as obese. I am 6' 2", currently 320...

www.excelmale.com

 

[SteveCleves]

My wife has been taking Semaglutide for a few months and is down about 25-30 lbs without any of the unpleasant gastric side effects. Her doc told her that when she reaches her target weight that she would be switched to a maintenance dose. I don't know whether that means the same dosage less frequently or a lower weekly dosage, nor do we know what will be recommended for overall duration. But it sounds like her doctor is leaning towards "indefinitely".

I did a fair amount of investigation into Semaglutide before I went on it. Spent A LOT of time on the various ******** groups, forums etc. From my observations there are 2 responses to Semaglutide

1 Absolute horror, nausea, vomiting, pain, headaches, can't sleep, heart issues, basically the experience is torture. It starts with the lowest dose and these people just can't tolerate the drug at all and go off it.

2 Almost no side effects, or very very limited side effects. Nothing but positive effects. The weight seems to just melt off.

There isn't really an in between from the experiences I've seen. Either it works or you feel like your al qaeda in Gitmo in 2002.

 

[bixt]

Look like last pic today (a little leaner

Thats fantastic! I missed the earlier thread where you posted it.

I always pictured you to be this nerd reading studies in his basement (subconsciously your name alluded to that mental impression), nice to finally be able to see that the real @readalot is actually the real deal! (as far as a "high T" look is concerned, which is the ultimate judge of knowledge being put into practise). It certainly gives a lot of credence that what you preach is not wrong.

Respect!

 

[tareload]

Thats fantastic! I missed the earlier thread where you posted it.

I always pictured you to be this nerd reading studies in his basement (subconsciously your name alluded to that mental impression), nice to finally be able to see that the real @readalot is actually the real deal! (as far as a "high T" look is concerned, which is the ultimate judge of knowledge being put into practise). It certainly gives a lot of credence that what you preach is not wrong.

Respect!

Thanks for the kind words. Regarding the Nerd reading studies...you got me haha!

To your point one really doesn't know who they are talking to on the other end of the screen. That's why I never was a big fan of credentials and all that on the forums. Folks should judge based on the information presented and decide for themselves. But I understand a pic is helpful sometimes.

Tren! Can't Gain Weight, No Appetite

If you would actually look closer, you would see how i never responded to you, and never talked to you, but you keep trying to get to me. This is the last time i ever speak to you, because as i said - you are nothing, so i just dont care. If you cant actually show yourself, you are a coward and...

forums.t-nation.com

 

[tareload]

Remember, when clinical trials last one year never be early adopter for miracle drugs when other less sexy methods will work just fine.

A potentially serious adverse effect of GLP-1 receptor agonists

www.sciencedirect.com

The risk of chronic intestinal obstruction in humans cumulates over time, with the highest occurrence appearing 1.6 years following GLP-1RA treatment5. However, clinical trials on GLP-1RAs usually do not last for more than a year and relevant studies revealed that the incidence of constipation is independent of short-term doses of GLP-1RAs14. We thus extracted a plot of the relationship between the incidence of constipation and the duration of treatment for four GLP-1RAs (Fig. 2) using the data from high-quality randomized controlled clinical trials. The result indicates that constipation was positively correlated with the duration of therapy (r2 = 0.8–0.9).

1. Download : Download high-res image (437KB)
2. Download : Download full-size image

Figure 2. The incidence of drug-induced constipation correlated with time from the data of four different doses of glucagon-like peptide-1 receptor agonists in 11 randomized and placebo controlled clinical studies15-25.

Since intestinal obstruction is a fatal condition that requires surgery, clinicians should be aware that the emergence of chronic adverse events of GLP-1RAs may involve the small intestine. If the underlying cause of which remains unknown, erroneous inferences will likely to be drawn. This is of particular importance as the use of GLP-1RAs in treating multiple disorders is expanding tremendously.

 

[tareload]

https://ascpt.onlinelibrary.wiley.com/doi/epdf/10.1002/cpt.2430

 

[tareload]

I hope it doesn't turn out like this but this was what I thought about when I first heard of the latest miracle:

Fenfluramine/phentermine - Wikipedia

en.wikipedia.org

For this too young to remember or know about this.

Risk / benefit must always be strongly considered.