Do i remember correctly you are not taking any pregnenolone anymore?
TRT Effect on 5 Alpha Reductase and Upstream Hormones- Cause of Low Mood and Anxiety?
- Thread starter Gianluca
- Start date
Ya would love to see where ur levels sit on the LC/MS progesterone test. Would u be getting it done at quest?
What’s ur injectable prog protocol atm? Like dosage, frequency, time of day, where u inject, and I assume u inject it subQ?
Gianluca
Well-Known Member
correct, I take a click of a Pregn cream once in a while but not all the time. I still want to try to include it on my protocol sometime in the future though.
Gianluca
Well-Known Member
SubQ on the upper outer quadrant of my butt. I now take it every am, 1mg dose.
I still have to look at where to get my LC/MS for Progesterone.
Why that spot and not like ur abdominal fat? Jc
So u found that u feel better taking it in the am, opposed to before bed?
1mg seems like a solid dose. I mostly took between 1-2mg/ day, when I was using the injectable progesterone
Gianluca
Well-Known Member
I thought I would use that spot because I already use the abdomen for daily HCG, but I always wondered if there is any difference in absorption between different SC spots for oily injectables.
I'm no sure actually, my doc suggested to take it in the am since I was complaining of some sleep disturbances, and he mentioned that Pro at night may increase Cortisol.
Last edited:
Gianluca
Well-Known Member
@Cataceous what would you estimate is the peak time and half life of a 2.5mg ( 0.05 ml ) Progesterone Injection suspended in oil injected SC, considering its IM peak time is "within 8 hrs" at 10mg ( .2ml )?
Seagal
Well-Known Member
According to Mark Gordon, his patients take pregnenolone and dhea and none of them has any of these problems on TRT.
Nelson Vergel
Founder, ExcelMale.com
I am looking into it.
Nelson Vergel
Founder, ExcelMale.com
I was able to add the test:
Accurate and Affordable Progesterone Test- LC/MS
This is the most accurate progesterone test that has no potential interactions and can detect very low levels in men and women. Since it is performed with liquid chromatography and mass spectrometry, results are available after 5 to 7 business days.
Gianluca
Well-Known Member
Funny I was just looking into it last night, thanks for posting this.I was able to add the test:
Accurate and Affordable Progesterone Test- LC/MS
This is the most accurate progesterone test that has no potential interactions and can detect very low levels in men and women. Since it is performed with liquid chromatography and mass spectrometry, results are available after 5 to 7 business days.
Ref range for adult males is ≤0.3 ng/m, I remember seen a study showing normal levels being <.9 ng, but wondering if the different assay leads to a different ref range.
FunkOdyssey
Seeker of Wisdom
I think more accurate testing would have to trigger a reappraisal of what normal physiologic levels are in men. I'm very curious to see where the 1 mg daily dose you've been taking will land on this <= 0.3 ng/mL normal range, using the improved test method.
Nelson Vergel
Founder, ExcelMale.com
Got this from AI
The normal progesterone blood levels in men, as measured by liquid chromatography-tandem mass spectrometry (LC-MS/MS), are generally low and show minimal variation across different age groups. According to the available data:
The normal progesterone blood levels in men, as measured by liquid chromatography-tandem mass spectrometry (LC-MS/MS), are generally low and show minimal variation across different age groups. According to the available data:
- The average serum progesterone level in adult men is approximately 0.38 ± 0.13 ng/mL[5].
- Another study indicates that the progesterone levels in men range from 0.15 to 0.38 ng/mL[1].
Citations:
[1] Progesterone, LC/MS/MS
[2] Reproducibility of an assay to measure serum progesterone metabolites that may be related to breast cancer risk using liquid chromatography-tandem mass spectrometry
[3] Combined Liquid Chromatography–Tandem Mass Spectrometry Analysis of Progesterone Metabolites
[4] Development and validation of a LC-MS/MS method for the establishment of reference intervals and biological variation for five plasma steroid hormones
[5] LC-MS/MS Method for Rapid Quantification of Progesterone in Rabbit Plasma and Its Application in a Pharmacokinetic Study of the Transdermal Formulation
[6] Sex-specific Estrogen Levels and Reference Intervals from Infancy to Late Adulthood Determined by LC-MS/MS
[7] Reproducibility of an assay to measure serum progesterone metabolites that may be related to breast cancer risk using liquid chromatography-tandem mass spectrometry - PubMed
[8] Simultaneous Measurement of Thirteen Steroid Hormones in Women with Polycystic Ovary Syndrome and Control Women Using Liquid Chromatography-Tandem Mass Spectrometry
[9] Progesterone Quantitative by HPLC-MS/MS, Serum or Plasma | ARUP Laboratories Test Directory
[10] Liquid Chromatography-Tandem Mass Spectrometry-Based Characterization of Steroid Hormone Profiles in Healthy 6 to 14-Year-Old Male Children
[11] 070085: 17-OH Progesterone, LC/MS | Labcorp
[12] https://www.fertstert.org/article/S0015-0282(14)00190-3/fulltext
[13] LC-MS/MS test for progesterone outperforms traditional immunoassays
[14] Impact of sample extraction on the accurate measurement of progesterone in human serum by liquid chromatography tandem mass spectrometry
[15] https://academic.oup.com/jcem/article-pdf/98/7/3058/9050028/jcem3058.pdf
The normal progesterone blood levels in men, as measured by liquid chromatography-tandem mass spectrometry (LC-MS/MS), are generally low and show minimal variation across different age groups. According to the available data:
- The average serum progesterone level in adult men is approximately 0.38 ± 0.13 ng/mL.
- Another study indicates that the progesterone levels in men range from 0.15 to 0.38 ng/mL.
The normal progesterone blood levels in men, as measured by liquid chromatography-tandem mass spectrometry (LC-MS/MS), are generally low and show minimal variation across different age groups. According to the available data:
- The average serum progesterone level in adult men is approximately 0.38 ± 0.13 ng/mL[5].
- Another study indicates that the progesterone levels in men range from 0.15 to 0.38 ng/mL[1].
Citations:
[1] Progesterone, LC/MS/MS
[2] Reproducibility of an assay to measure serum progesterone metabolites that may be related to breast cancer risk using liquid chromatography-tandem mass spectrometry
[3] Combined Liquid Chromatography–Tandem Mass Spectrometry Analysis of Progesterone Metabolites
[4] Development and validation of a LC-MS/MS method for the establishment of reference intervals and biological variation for five plasma steroid hormones
[5] LC-MS/MS Method for Rapid Quantification of Progesterone in Rabbit Plasma and Its Application in a Pharmacokinetic Study of the Transdermal Formulation
[6] Sex-specific Estrogen Levels and Reference Intervals from Infancy to Late Adulthood Determined by LC-MS/MS
[7] Reproducibility of an assay to measure serum progesterone metabolites that may be related to breast cancer risk using liquid chromatography-tandem mass spectrometry - PubMed
[8] Simultaneous Measurement of Thirteen Steroid Hormones in Women with Polycystic Ovary Syndrome and Control Women Using Liquid Chromatography-Tandem Mass Spectrometry
[9] Progesterone Quantitative by HPLC-MS/MS, Serum or Plasma | ARUP Laboratories Test Directory
[10] Liquid Chromatography-Tandem Mass Spectrometry-Based Characterization of Steroid Hormone Profiles in Healthy 6 to 14-Year-Old Male Children
[11] 070085: 17-OH Progesterone, LC/MS | Labcorp
[12] https://www.fertstert.org/article/S0015-0282(14)00190-3/fulltext
[13] LC-MS/MS test for progesterone outperforms traditional immunoassays
[14] Impact of sample extraction on the accurate measurement of progesterone in human serum by liquid chromatography tandem mass spectrometry
[15] https://academic.oup.com/jcem/article-pdf/98/7/3058/9050028/jcem3058.pdf
Gianluca
Well-Known Member
I will probably take the test in a week or two, and then I will update you guys here.
I know with finasteride a lot of times the balance is thrown off indefinitely even if you stop. TRT would have a different mechanism of affecting it so it’s hard to say. If you do feel worse on TRT no matter the regime or trying to help it, might not be for you for a variety of reasons that can go beyond just 5AR.
Charliebizz
Well-Known Member
I always recommend trying the scrotal cream. I know so many guys who didn't do well on TRT until they made the switch.
Gianluca
Well-Known Member
I believe if someone is not using huge amount of test for prolonged time, I think probably there is not much to be concerned about the 5-ar. Lower levels of Progesteonre/Pregnenolone can be an issue for some
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