Ultra sensitive Estradiol Test results

bruin · Jul 7, 2014

[TABLE="class: fullwidth closed"]
[TR]
[TH="colspan: 7"]Estradiol[/TH]
[/TR]
[TR]
[TD="class: resultheader, colspan: 7"]Estradiol - Final
Result/Status Change: Jul 02, 2014 2:20 PM PDT
[TABLE="class: results"]
[TR]
[TH]Analyte[/TH]
[TH]Value[/TH]
[TH]Flag[/TH]
[TH="class: analyte"]Reference[/TH]
[TH]Units[/TH]
[TH]Status[/TH]
[TH]Site[/TH]
[/TR]
[TR]
[TD]Estradiol[/TD]
[TD]49[/TD]
[TD]H[/TD]
[TD="class: analyte"]0-40[/TD]
[TD]pg/mL[/TD]
[TD]Final[/TD]
[TD]EMC[/TD]
[/TR]
[TR]
[TD="colspan: 7"]Comments:
Estradiol Reference Ranges
Menstruating Females
(By day in cycle relative to LH peak) Range (pg/mL)
Follicular Phase (-12 to -4 days) 20 - 144
Mid-cycle (-3 to +2 days) 64 - 357
Luteal Phase (+4 to +12 days) 56 - 214
Post-menupausal Females (untreated) ND - 32

this was from a draw last week, pulled teeth to get the order.
Value is above reference range, for menstruating females...? huh. have not checked other post on here yet, I believe this range is or may be incorrect .....?

Duane
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bruin · Jul 7, 2014

the following results from the previous draw, previous week

[TABLE="class: fullwidth closed"]
[TR]
[TH="colspan: 7"]Testosterone, Free, Bioavail, TotaL[/TH]
[/TR]
[TR]
Testosterone, Free, Bioavail, TotaL - Final
Result/Status Change: Jun 13, 2014 1:01 PM PDT
[TABLE="class: results"]
[TR]
[TH]Analyte[/TH]
[TH]Value[/TH]
[TH]Flag[/TH]
[TH="class: analyte"]Reference[/TH]
[TH]Units[/TH]
[TH]Status[/TH]
[TH]Site[/TH]
[/TR]
[TR]
[TD]Testosterone, Free, S[/TD]
[TD]24[/TD]
[TD="class: analyte"]9-30[/TD]
[TD]ng/dL[/TD]
[TD]Final[/TD]
[TD]MAYO[/TD]
[/TR]
[TR]
[TD="colspan: 7"]Comments:
Testing performed by Equilibrium Dialysis.

[/TD]
[/TR]
[TR]
[TD]Testosterone, Total, S[/TD]
[TD]920[/TD]
[TD][TD="class: analyte"]240-950[/TD]
[TD]ng/dL[/TD]
[TD]Final[/TD]
[TD]MAYO[/TD]
[/TR]
[TR]
[TD="colspan: 7"]Comments:
Testing performed by Liquid Chromatography-Tandem Mass
Spectrometry (LC-MS/MS).

[/TD]
[/TR]
[TR]
[TD]Testosterone, Bioavailable, S[/TD]
[TD]294[/TD]
[TD]H[/TD]
[TD="class: analyte"]50-190[/TD]
[TD]ng/dL[/TD]
[TD]Final[/TD]
[TD]MAYO[/TD]
[/TR]
[TR]
[TD="colspan: 7"]Comments:
Testing performed by Differential Precipitation.

Test Performed by:
Mayo Clinic Laboratories - Rochester Main Campus
200 First Street SW, Rochester, MN 55905
Laboratory Director: Franklin R. ****erill, III, M.D.

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bruin · Jul 7, 2014

Metabolic Panel

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[TR]
[TH="colspan: 7"]Comprehensive Metabolic Panel[/TH]
[/TR]
[TR]
Comprehensive Metabolic Panel - Final
Result/Status Change: Jun 11, 2014 1:58 PM PDT
[TABLE="class: results"]
[TR]
[TH]Analyte[/TH]
[TH]Value[/TH]
[TH]Flag[/TH]
[TH="class: analyte"]Reference[/TH]
[TH]Units[/TH]
[TH]Status[/TH]
[TH]Site[/TH]
[/TR]
[TR]
[TD]Sodium[/TD]
[TD]136[/TD]
[TD]L[/TD]
[TD="class: analyte"]137-147[/TD]
[TD]mmol/L[/TD]
[TD]Final[/TD]
[TD]EMC[/TD]
[/TR]
[TR]
[TD]Potassium[/TD]
[TD]4.2[/TD]
[TD="class: analyte"]3.5-5.1[/TD]
[TD]mmol/L[/TD]
[TD]Final[/TD]
[TD]EMC[/TD]
[/TR]
[TR]
[TD]Chloride[/TD]
[TD]108[/TD]
[TD="class: analyte"]99-109[/TD]
[TD]mmol/L[/TD]
[TD]Final[/TD]
[TD]EMC[/TD]
[/TR]
[TR]
[TD]CO2 Total[/TD]
[TD]24[/TD]
[TD="class: analyte"]24-32[/TD]
[TD]mmol/L[/TD]
[TD]Final[/TD]
[TD]EMC[/TD]
[/TR]
[TR]
[TD]Glucose[/TD]
[TD]85[/TD]
[TD="class: analyte"]70-100[/TD]
[TD]mg/dL[/TD]
[TD]Final[/TD]
[TD]EMC[/TD]
[/TR]
[TR]
[TD]BUN[/TD]
[TD]16[/TD]
[TD="class: analyte"]5-24[/TD]
[TD]mg/dL[/TD]
[TD]Final[/TD]
[TD]EMC[/TD]
[/TR]
[TR]
[TD]Creatinine[/TD]
[TD]1.1[/TD]
[TD="class: analyte"]0.8-1.3[/TD]
[TD]mg/dL[/TD]
[TD]Final[/TD]
[TD]EMC[/TD]
[/TR]
[TR]
[TD]Osmolality - Calculated[/TD]
[TD]272[/TD]
[TD="class: analyte"]270-295[/TD]
[TD]mOsmo/KG[/TD]
[TD]Final[/TD]
[TD]EMC[/TD]
[/TR]
[TR]
[TD]BUN/CREAT[/TD]
[TD]15[/TD]
[TD="class: analyte"]7-24[/TD]
[TD]Ratio[/TD]
[TD]Final[/TD]
[TD]EMC[/TD]
[/TR]
[TR]
[TD]Anion Gap[/TD]
[TD]4[/TD]
[TD="class: analyte"]4-12[/TD]
[TD]mmol/L[/TD]
[TD]Final[/TD]
[TD]EMC[/TD]
[/TR]
[TR]
[TD]Total Protein[/TD]
[TD]7.6[/TD]
[TD="class: analyte"]5.3-8.3[/TD]
[TD]gm/dL[/TD]
[TD]Final[/TD]
[TD]EMC[/TD]
[/TR]
[TR]
[TD]Albumin[/TD]
[TD]3.7[/TD]
[TD="class: analyte"]3.4-5.0[/TD]
[TD]gm/dL[/TD]
[TD]Final[/TD]
[TD]EMC[/TD]
[/TR]
[TR]
[TD]Calcium[/TD]
[TD]9.0[/TD]
[TD="class: analyte"]8.5-10.4[/TD]
[TD]mg/dL[/TD]
[TD]Final[/TD]
[TD]EMC[/TD]
[/TR]
[TR]
[TD]Bilirubin Total[/TD]
[TD]0.3[/TD]
[TD="class: analyte"]0.1-1.5[/TD]
[TD]mg/dL[/TD]
[TD]Final[/TD]
[TD]EMC[/TD]
[/TR]
[TR]
[TD]ALT (SGPT)[/TD]
[TD]36[/TD]
[TD="class: analyte"]12-78[/TD]
[TD]U/L[/TD]
[TD]Final[/TD]
[TD]EMC[/TD]
[/TR]
[TR]
[TD]AST (SGOT)[/TD]
[TD]33[/TD]
[TD="class: analyte"]5-37[/TD]
[TD]U/L[/TD]
[TD]Final[/TD]
[TD]EMC[/TD]
[/TR]
[TR]
[TD]Alkaline Phosphatase[/TD]
[TD]95[/TD]
[TD="class: analyte"]30-136[/TD]
[TD]U/L[/TD]
[TD]Final[/TD]
[TD]EMC[/TD]
[/TR]
[TR]
[TD]eGFR Non African American[/TD]
[TD]>=60[/TD]
[TD="class: analyte"]>=60[/TD]
[TD]mL/min/1.73m sq[/TD]
[TD]Final[/TD]
[TD]EMC[/TD]
[/TR]
[TR]
[TD]eGFR African American[/TD]
[TD]>=60[/TD]
[TD][TD="class: analyte"]>=60[/TD]
[TD]mL/min/1.73m sq[/TD]
[TD]Final[/TD]
[TD]EMC[/TD]
[/TR]
[TR]
[TD="colspan: 7"]Comments:
eGFR results <60 mL/min/1.73m sq are below the reference range.
Please note: Results below the reference range do not flag in
the lab computer system.
*The equation has not been validated in patients older than age
70, but an MDRD-derived eGFR may still be a useful tool for
providers caring for patients older than 70.

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Bass · Jul 7, 2014

that does not look like the sensitive assay, and it needs to come down in my opinion. is this labcorp test, and do you have a question?

Gene Devine · Jul 7, 2014

It may be the Ultra Sensitive assay as my Ultra Sensitive peaks at 42.5 pg/ml...nevertheless it's high and should in the 20's if a Sensitive assay.

Your Free Testosterone is way over the reference range as well which (and not seeing SHBG) means your Testosterone dosage is too high (also need to see Total Testosterone lab) and would be indicated by your E2 being over the reference range as well.

Always remember E follows T.

Drop your Testosterone dosage drop E2...if you are injecting try injecting twice weekly as this will help with E2 management as well.

bruin · Jul 7, 2014

These test are performed by the Mayo Clinic.
This is my first test so I don't know what it is supposed to look like.
My initial thoughts are that the E is high.
The Dr did not order a Total T lab, or SHBG.
This is a relief Dr filling in for my reg doc who is out sick he did offer that he was not very proficient about HRT in general.
Furthermore, it is my opinion that he should have called to discuss these issues, but then again this is not his schtick, so it would not raise a flag. I will speak to him and request a referral to an Endo, possibly, just seek out another doc in the interim for a second opinion.
I inject twice a week, ( 1000 total), so, what, arbitrarily drop the dose to 800 a week? 700, 600 a week?

Bass · Jul 8, 2014

numbers don't mean anything if you don't feel good, both go hand and hand. rule of thumb is, whatever you do make sure you stay in optimal range on the scale, but the main thing is how you feel.

bruin · Jul 8, 2014

OMG............Im feeling great, I am feeling so good, energy, everything. Physiologically, mentally and physically I could not ask for more right now with my body humming like a fine tuned machine, mental acuity high and some decrease in body fat with marked definition and muscle gain (weight). I have a genetic predisposition to anemia, and since HRT no recurrence.

I think I will drop my dose to 400 / 2x week , and monitor any fluctuations.

Bass · Jul 8, 2014

please clarify your dose, I don't understand what you mean by 400 / 2x week!

Gene Devine · Jul 8, 2014

Bass said:
please clarify your dose, I don't understand what you mean by 400 / 2x week!

^^^^What the wise one said above...I am confused with this dosage as well.

bruin · Jul 8, 2014

uh oh......yeah I screwed up........my current prescribed dose is 0.5 ml 1/week. I have been splitting that up to twice weekly IM. So, will look at reducing the dose respectively and maintain twice weekly IM.