Progesterone Dose for Men

DixieWrecked · Apr 17, 2021

Progesterone For Men – The Feel Good Hormone

*The results described are not typical and will vary based on a variety of factors. Progesterone Progesterone is known as our calming, mood, sleep, libido and bone-enhancing hormone. What a lot of men also don’t realize

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If you're asking why we need progesterone, here are some good answers

If you've been asking why we need progesterone, here are some answers about why it is necessary for longevity and good health

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Was just doing some research on progesterone. Has anyone had it tested and corrected a deficiency? Anyone noticed an improvement in symptoms from this?

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Progesterone, often considered a "female hormone," plays a crucial role in men's health by influencing various physiological, psychological, and reproductive functions. Below is a summary of its key benefits for men:

Reproductive and Sexual Health

Testosterone Production: Progesterone acts as a precursor to testosterone, helping maintain healthy levels of this vital male hormone1 4 6.
Sperm Function: It supports sperm production, maturation, and the processes necessary for successful fertilization1 4.
Sexual Function: Adequate progesterone levels help prevent erectile dysfunction and low libido by balancing testosterone and estrogen levels2 7.

Mental Health

Mood Regulation: Progesterone promotes the production of GABA, a calming neurotransmitter, reducing anxiety and improving mood3 4.
Sleep Quality: Its sedative effects enhance sleep by reducing brain activity and addressing sleep disturbances like apnea1 3 5.

Physical Health

Bone Health: It supports bone density, reducing the risk of osteoporosis1 5.
Muscle Maintenance: Progesterone helps preserve lean muscle mass and prevents muscle loss associated with aging1 6.
Prostate Health: Maintaining adequate levels reduces the risk of prostate enlargement and cancer1 6.
Weight Regulation: It aids in appetite control and fat metabolism, helping avoid weight gain linked to hormonal imbalances1 6.

Cardiovascular and Immune System Benefits

Progesterone may improve circulation, lower blood pressure, and act as an immunosuppressant to reduce inflammation or autoimmune risks4.

Symptoms of Deficiency

Low progesterone in men can lead to:

Estrogen dominance, causing symptoms like gynecomastia, fatigue, weight gain, and decreased libido2 7.
Psychological effects such as depression, anxiety, and poor sleep quality1 3.
Physical issues like bone loss, muscle atrophy, and increased risk of prostate problems5 7.

Conclusion

Progesterone is essential for maintaining hormonal balance in men. Its benefits extend beyond reproductive health to include mood stabilization, sleep improvement, muscle preservation, and protection against conditions like osteoporosis and prostate disease. For men experiencing symptoms of hormonal imbalance, testing progesterone levels and considering supplementation under medical supervision can be transformative.

Citations:

Answer from Perplexity: pplx.ai/share

JA Battle · Apr 17, 2021

I know cataceous injects progesterone. I also have progesterone for injection however I’ve yet to use it. I’ve used topical in the past. Without supplementation I measure .4 in the 0-.5 range so I haven’t tried it yet. This is one thing I’m sure the reference range has no clue about

DixieWrecked · Apr 17, 2021

Was looking at the short half life of progesterone. I wonder how that would affect everything. You did scrotal application right? Noticed anything? Ever thought about a sustained released pill from a compounder?

ivkonst2017 · Apr 18, 2021

By the way my progesterone has always been over the range, even after starting TRT increased a bit. Hasnt tested it for at least 6-7 months. What effects you think that might have?

DixieWrecked · Apr 18, 2021

Calming effect to allow better erections.

Cataceous · Apr 18, 2021

DixieWrecked said:
...
Was just doing some research on progesterone. Has anyone had it tested and corrected a deficiency? Anyone noticed an improvement in symptoms from this?

Yes. I previously measured 0.1 ng/mL (0.0-0.5) on LabCorp's test, even with hCG use. I've been supplementing for two years now to get to midrange, ~0.3 ng/mL. For me, in isolation it improves sleep. But I also think having normal levels is a piece of the puzzle in getting good results from TRT. It may be needed to balance against estradiol and DHT.

DixieWrecked · Apr 18, 2021

Cataceous said:
Yes. I previously measured 0.1 ng/mL (0.0-0.5) on LabCorp's test, even with hCG use. I've been supplementing for two years now to get to midrange, ~0.3 ng/mL. For me, in isolation it improves sleep. But I also think having normal levels is a piece of the puzzle in getting good results from TRT. It may be needed to balance against estradiol and DHT.

That's what I am thinking. What are some of the methods you have used to supplement and how did they go?

I wonder if the people whose upstream hormones are not as affected feel great on TRT, and vice versa.

JA Battle · Apr 18, 2021

DixieWrecked said:
Was looking at the short half life of progesterone. I wonder how that would affect everything. You did scrotal application right? Noticed anything? Ever thought about a sustained released pill from a compounder?

I have considered it and soon after lost interest as I became aware that the pass through the liver really lowers its bioavailability. A good part of that lowered availability is actually not that it is not available but rather it heavily metabolizing into up to 30 other hormones. It feels like more of a crapshoot taking any hormones orally to me. Transdermal is a little better though if you get the right product.

I prefer injection. The key I believe will be taking it in a large enough oil depot to slow down its absorption. A good part of half life is the size of the injection. I want dilute it so I have to inject .5 ml to get the .6 mg cataceous is injecting. I also may do this twice daily as the half life will be short.

Half life isn’t everything, as the tissues absorb hormones that they have use for and the effects persist for a while (vague description I know).

Cataceous · Apr 18, 2021

DixieWrecked said:
... What are some of the methods you have used to supplement and how did they go?
...

I initially used progesterone in coconut oil applied to the scrotum, ~7 mg. This gave good results but seemed a little messy and imprecise. The product is easily obtained on Amazon.

I switched to an injectable form obtained from AllDayChemist. I use only 0.6 mg per day. It sounds like Defy is willing to prescribe it, so that will probably be the source of my next batch.

I rejected oral dosing for the reason stated by @JA Battle.

DixieWrecked said:
...
I wonder if the people whose upstream hormones are not as affected feel great on TRT, and vice versa.

I think there's something to this, and the list of upstream hormones that may be disrupted by TRT is getting pretty long: LH, FSH, GnRH, kisspeptin, progesterone, pregnenolone...

JA Battle · Apr 18, 2021

Cataceous said:
I initially used progesterone in coconut oil applied to the scrotum, ~7 mg. This gave good results but seemed a little messy and imprecise. The product is easily obtained on Amazon.

I switched to an injectable form obtained from AllDayChemist. I use only 0.6 mg per day. It sounds like Defy is willing to prescribe it, so that will probably be the source of my next batch.

I rejected oral dosing for the reason stated by @JA Battle.

I think there's something to this, and the list of upstream hormones that may be disrupted by TRT is getting pretty long: LH, FSH, GnRH, kisspeptin, progesterone, pregnenolone...

Interestingly, I decided last night to begin progesterone injection as I know I’m no where near my newly conceived target level of the high end of the old reference range. I accidentally injected 3x my planned dose of .6 per dose for a total of 1.8mg. I ended up falling asleep quickly and it was a deeeeep sleep. Today I noticed I feel more social and my mid morning oral temp is 98.6 which is .5 degrees higher than normal.

I’m going to inject .6mg morning and night. In the morning, intramuscularly with my larger shot containing test e, test p, estradiol v, and dht v.

At night subq with my magnesium in DMSO.

Very interesting findings. I’m going to be making an injectable dhea or dheas and pregnenolone if possible to get those hormone to high end of range.

ivkonst2017 · Apr 18, 2021

In fact I see now I have tested progesterone, last in December:

Progesteron

S

0.31

ng/ml

0.05 - 0.15

ECLIA

According to my lab the upper range for men is up to 0.15ng/ml. I have before tested 0,17 and 0.2

JA Battle · Apr 18, 2021

Interestingly I am in the zone this morning following my 1.8mg injection of progesterone. Listening to music, planning action, not even a thought of sitting down or playing video games. When a song ends on my home sound system I’m like running to pick a new song. 24 oz Coffee feels stronger today. Haha it’s weird but progesterone feels androgenic. Like some swagger is emerging from within the man.

I’m thinking that disrupting ones hpha’s requires broader replacement of hormones. Preg, prog, dhea, test, e2, dht all need to be solid. Then move on to next. Sex steroids can alter creation and metabolism of thyroid and adrenal hormones.

If we are destined for sex steroid replacement might as well make sure each one is squared away.

A large point of thyroid is to facilitate/create robust amounts of all of the sex steroids. And the steroids in return assist with making sure thyroid keeps doing it. Positive feedback between all of these systems is broken with one abnormal hormone.

Gman86 · Apr 18, 2021

ivkonst2017 said:
In fact I see now I have tested progesterone, last in December:

Progesteron

S

0.31

ng/ml

0.05 - 0.15

ECLIA

According to my lab the upper range for men is up to 0.15ng/ml. I have before tested 0,17 and 0.2

How is ur level so high? Are u taking anything for it?

Gman86 · Apr 18, 2021

Cataceous said:
I initially used progesterone in coconut oil applied to the scrotum, ~7 mg. This gave good results but seemed a little messy and imprecise. The product is easily obtained on Amazon.

I switched to an injectable form obtained from AllDayChemist. I use only 0.6 mg per day. It sounds like Defy is willing to prescribe it, so that will probably be the source of my next batch.

I rejected oral dosing for the reason stated by @JA Battle.

I think there's something to this, and the list of upstream hormones that may be disrupted by TRT is getting pretty long: LH, FSH, GnRH, kisspeptin, progesterone, pregnenolone...

What time of day do u inject the 0.6mg of progesterone?

Do u inject it shallow IM or SubQ?

Cataceous · Apr 18, 2021

Gman86 said:
What time of day do u inject the 0.6mg of progesterone?

Do u inject it shallow IM or SubQ?

Subcutaneous at bedtime.

ivkonst2017 · Apr 18, 2021

Gman86 said:
How is ur level so high? Are u taking anything for it?

no. it has been 0.2 even before starting trt

Gman86 · Apr 18, 2021

ivkonst2017 said:
no. it has been 0.2 even before starting trt

So it’s been above range before TRT, and after starting TRT its even higher? Never seen that before. I’ve only seen progesterone go down on TRT, and have never seen someone naturally above the top of the range

Charliebizz · Apr 19, 2021

JA Battle said:
Interestingly I am in the zone this morning following my 1.8mg injection of progesterone. Listening to music, planning action, not even a thought of sitting down or playing video games. When a song ends on my home sound system I’m like running to pick a new song. 24 oz Coffee feels stronger today. Haha it’s weird but progesterone feels androgenic. Like some swagger is emerging from within the man.

I’m thinking that disrupting ones hpha’s requires broader replacement of hormones. Preg, prog, dhea, test, e2, dht all need to be solid. Then move on to next. Sex steroids can alter creation and metabolism of thyroid and adrenal hormones.

If we are destined for sex steroid replacement might as well make sure each one is squared away.

A large point of thyroid is to facilitate/create robust amounts of all of the sex steroids. And the steroids in return assist with making sure thyroid keeps doing it. Positive feedback between all of these systems is broken with one abnormal hormone.

I know a few people who were able to resolve all other hormone issues by correcting thyroid. They had decent thyroid numbers on paper but lower body temps. Once the corrected body temp issues t levels came way up.

It was also a lot more involved then just taking thyroid meds. I myself have lower body temps but haven't been able to raise them much. And can't seem to tolerate thyroid meds. I am always looking for a way to avoid trt do to the hpta shutdown but always end up back on it lol

ivkonst2017 · Apr 19, 2021

Gman86 said:
So it’s been above range before TRT, and after starting TRT its even higher? Never seen that before. I’ve only seen progesterone go down on TRT, and have never seen someone naturally above the top of the range

Not sure either, all I can say is with TRT I've most of the time been on HCG as well so I guess this may play a part as well

Gman86 · Apr 19, 2021

ivkonst2017 said:
Not sure either, all I can say is with TRT I've most of the time been on HCG as well so I guess this may play a part as well

That definitely can play a role. When I was using pregnyl HCG it would significantly raise my DHEA-S way out of range and also raise my progesterone level quite a bit

what brand of HCG are u using? If it’s from a compounding pharmacy, what compounding pharmacy is it from? And what’s ur dose per week?