Why All Men Should be Tested with the Sensitive Estradiol Test

Vince Carter · Dec 29, 2014

The forum suggested to me the LabCorp 140244

https://www.labcorp.com/wps/portal/...?testId=408440&criterion=Estradiol,+Sensitive

a_crossfitter · Dec 29, 2014

Vince Carter said:
The forum suggested to me the LabCorp 140244

https://www.labcorp.com/wps/portal/...?testId=408440&criterion=Estradiol,+Sensitive

Which forum? I erroneously linked to the wrong test, thankfully Nelson corrected me, so hopefully you are not referencing to my post...

140244 is less accurate than 500108.

croaker24 · Dec 30, 2014

How less accurate exactly? Two months ago I had a 19 on the 140244 test.

Vince Carter · Dec 30, 2014

a_crossfitter said:
Which forum? I erroneously linked to the wrong test, thankfully Nelson corrected me, so hopefully you are not referencing to my post...

140244 is less accurate than 500108.

I got it from two moderators on this forum.

a_crossfitter · Dec 30, 2014

croaker24 said:
How less accurate exactly? Two months ago I had a 19 on the 140244 test.

Nelson, you might want to chime in....

I dont know why 140244 is less accurate than 500108. I am going off of Nelson's experience with dealing with labcorp.

I've had 140244 myself.

140244 gave me a result of 37 pg/ml while the normal estradiol gave me a 66.9 pg/ml. Both results were for the same collection sample.

Go figure!

Vince Carter · Dec 30, 2014

And that's why the sensitive is more accurate than the standard. One is a little high, the other is basically off the charts. I know the difference in mine 19/32 isn't far off from being double the difference. I'm sure if I hadn't taken the wheel my provider would have suggested even more Anastrozole than the .25mg EOD I was on. I was nearly crashed on low E2 and would have continued treating HIGH E2. Go figure.

JanSz · Dec 30, 2014

a_crossfitter said:
Nelson, you might want to chime in....

I dont know why 140244 is less accurate than 500108. I am going off of Nelson's experience with dealing with labcorp.

I've had 140244 myself.

140244 gave me a result of 37 pg/ml while the normal estradiol gave me a 66.9 pg/ml. Both results were for the same collection sample.

Go figure!

Interesting, I am also using 140244 succesfully.

..

croaker24 · Dec 30, 2014

croaker24 said:
How less accurate exactly? Two months ago I had a 19 on the 140244 test.

And for the record, I got a 43 or so on the standard test.

Nelson Vergel · Jan 27, 2015

I was able to find the right estradiol blood test based on mass spectrometry/liquid chromatography:

Affordable sensitive estradiol test

croaker24 · Jan 27, 2015

Nelson Vergel said:
I was able to find the right estradiol blood test based on mass spectrometry/liquid chromatography:

Affordable ultrasensitive estradiol test

Definitely affordable! The test description states:

The commonly used estradiol test may overestimate estradiol. That test uses immunoassay technology that cannot differentiate C-Reactive Protein (involved in inflammation) from estradiol, so it reads the combination of the two as estradiol. This ultra-sensitive estradiol test is based on liquid chromatography/mass spectrometry (LC/MS), an assay technology that does not have that limitation.

What test is it referencing ("commonly used estradiol test"), the standard or the sensitive?

Nelson Vergel · Jan 28, 2015

The regular estradiol test is based on immunoassay ECLIA technology. The one offered by DiscountedLabs.com is the sensitive one that uses mass spectrometry/liquid chromatography (MS/LC). MS/LC has no interference from C-reactive protein. Immunoassay-based estradiol tests tend to overestimate estradiol since they "see" C-reactive protein as estradiol. My concern is that men are basing their decision to take anastrozole based on a test that is over estimating their estradiol value. This results in over treatment or treatment that may not be needed. Estradiol is important for men's health!

Big b · Mar 12, 2015

Nelson Vergel said:
I was able to find the right estradiol blood test based on mass spectrometry/liquid chromatography:

Affordable ultrasensitive estradiol test

Thank you so much for this information Nelson. My estrogen got out of control when I stopped my ai for awhile and I've been trying to get it back in line. I was using aromasin and my estrogen came back a 7.5pg/ml on a scale of 7.6-42.6 pg/ml. Stopped my aromasin and three weeks later I was 494 on a scale of 40-115 pg/ml. I have switched to arimidex (that's all they will prescribe me now) at .5mgs a day for three weeks and feel better, but I can't get rid of the face bloat and my eyes are puffy. I wanted to try adex because it seems like estrogen comes back faster if you drop it too low, but I am so tired of trying to find the right dosage. I was going to do .5mgs adex for three weeks to a month and then switch to 1mg a week in split doses and see if that kept in under control. I just don't know how long this adex dosage will take to get things under control. I'm going to get a blood test tomorrow and see where estrogen is at.

Hydrus · Apr 18, 2015

just wanted to say this thread has some good info, thanks for sharing. I am going through the same stuff right now. First E was in range and next time it's over range. Dr. put me on .5mg a day yesterday. I do have symptoms of high E but I'm not even on hrt yet.

tornquad2 · May 16, 2015

is there a difference i asked my doctor to include estridial on my labs and it read as estrogen non pregnant

Vince Carter · May 16, 2015

Hydrus said:
just wanted to say this thread has some good info, thanks for sharing. I am going through the same stuff right now. First E was in range and next time it's over range. Dr. put me on .5mg a day yesterday. I do have symptoms of high E but I'm not even on hrt yet.

that is an OVERDOSE... .5mg PER DAY...you need to not do that and then consider the treatment this Dr is providing you.

Vince Carter · May 16, 2015

tornquad2 said:
is there a difference i asked my doctor to include estridial on my labs and it read as estrogen non pregnant

most certainly its the wrong test. post the result with the reference range for us to look at.

tornquad2 · May 16, 2015

mine was 40 on ref up to 60 i think

tornquad2 · May 16, 2015

i knew he didnt know what i was asking cause of the look he gave me,i asked cause i though my e2 was low as i had good erections but dull ejaculation and no libido

Vince Carter · May 16, 2015

if this Dr is agreeable to being spoon fed by his patient, ask for either of these tests, depending on the lab he uses:

Quest 140244 sensitive estradiol LC/MS/MS
LabCorp 500108 Sensitive Estradiol LC/MS/MS

Further consider if this Dr is helping or hurting you.