What Could Cause Gyno When Estrogen is Low?

[hfbjr]

Hello guys,just wondering if anyone had any ideas what would be a cause of gyno in a male who has low estrogen?it runs in my family,as it's evident in the males.
I don't know my prolactin levels yet,although I'm not having any discharge whatsoever.

I do have chest fat on sides,too.im not however, overweight.i do have some very small hard masses too. I'm wondering if stress can cause the gyno,as I'm a "worry wort"

Besides prolactin,anything else I need checked to rule out the evil cause?

 

[ERO]

If it runs in the family, that is likely it. You may have posted this elsewhere, but what is your Total and Free T levels? Low E2 is not necessarily low if you have super low Total and Free T as well. The T to E ratio may still be tilted toward too much E2. That is only a guess without numbers, though.

 

[hfbjr]

Total was 425 ref 175-781
Free t was 99 ref 47 -244
Estrogen sensitive was 12.6 ref 10-42
Estrone19.8 ref 9-42

 

[hfbjr]

I'm learning everyday from these posts.so basically,if my testosterone is low,the ratio to estrogen can still be high? Makes sense.

 

[Vince Carter]

I'd suggest along with Prolactin, and the sensitive Estradiol again, consider Pregnenolone and Progesterone. Just brain-storming.

 

[hfbjr]

Thanks vince,I appreciate it.

 

[Vettester Chris]

I'd suggest along with Prolactin, and the sensitive Estradiol again, consider Pregnenolone and Progesterone. Just brain-storming.

x2! That's where I was leaning, especially on the prolactin/progesterone side of it.

If you (hfbjr) have by chance used some larger doses of Nor19 anabolics, e.g., Deca, Tren ..., then that subject can be an issue? If you haven't, but you find an issue with your labs, possibly it will need a deeper look into the pituitary? It's speculation right now, run labs!

 

[Nelson Vergel]

IGF-1 has been linked to gynecomastia.

Gynecomastia Associated with a Combination of High IGF-1 and Estradiol In Adolescents
Several other causes are also linked:

Gynecomastia: Clinical evaluation and management

 

[ERO]

Your T to E ratio is 37 and the ideal range is 14-20. So in keeping with the T:E ratio theory, your E2 is low in relation to your T (as well as low in terms of the range on the test). Said another way, my speculation about your T being super low proved false.

 

[hfbjr]

Thanks for the replies.never used any anabolic steroids.back in 2006 I had surgery to remove gyno,which is odd that it's back.

Ero,can you explain, you lost me on your post,but I know it's an important one.it just confused me some.

 

[ERO]

There is a theory called the Testosterone to Estrogen ratio. Basically, it takes into account the fact that men need a certain amount of both T and E2 and that more important than a static number for each of them is the ratio between the two. Young healthy men have a T:E ratio of between 14 and 20. So for example if you had an E2 of 30 and a Total T of 600, your T:E ratio would be 20.

This concept is logical when you think about it and it helps show why striving toward a specific number on a test can be futile. For example, a lot of guys want to get their E2 to be right at, lets use 30 again. Well, if they have a Total T of 900 or 1000, which would be common on TRT, their ratio is blown out of the water and that E2 number is way too low for those Total T levels. With a Total T of 900 and an E2 of 30, the T:E ratio is 30, and for a Total T of 1000 and an E2 of 30 the T:E ratio is 33.3.

Now there is always the exception - say the guy that is super sensitive to E2 and that needs a lower E2 level than most guys to feel good - but by and large the T:E ratio is a handy guideline and helps one to get past chasing his tail trying to get to a set number on a blood test.

 

[Jasen Bruce]

Do you drink alcohol regularly? breast tissue exists in every male, it just becomes a problem when influenced by certain hormones or chemicals. If your E2 is in range it may be something else you are exposed to.

Another consideration is your 'free estradiol" levels. If your SHBG is too low it will allow free E2 to increase. I know someone who experienced gynecomastia even though E2 and prolactin were low. He started taking oxandrolone which lowered SHBG and the gyno symptoms showed up quickly after.

Gynecomastia is more complex then just measure estradiol and prolactin.

To rule out hormones try getting the following panel to check hormones that may influence gynecomastia:

Testosterone F&T
Sensitive Estradiol (LC/MS)
DHEA
Prolactin
IGF-1
CBC
CMP (chemistries)
Sex Hormone Binding Globulin
Free t3

 

[Vince Carter]

Its a not so known thing that with SHBG = High Free T = High Free Estrogen...can be really tough for us to manage.

 

[hfbjr]

With a t to e ratio of 37,would that warrant a micro dose of arimidex?also,I would think that introducing 80 mg of testosterone x2 a week would send it up higher too.

 

[100% PAUL]

Do you drink alcohol regularly? breast tissue exists in every male, it just becomes a problem when influenced by certain hormones or chemicals. If your E2 is in range it may be something else you are exposed to.

Another consideration is your 'free estradiol" levels. If your SHBG is too low it will allow free E2 to increase. I know someone who experienced gynecomastia even though E2 and prolactin were low. He started taking oxandrolone which lowered SHBG and the gyno symptoms showed up quickly after.

Gynecomastia is more complex then just measure estradiol and prolactin.

To rule out hormones try getting the following panel to check hormones that may influence gynecomastia:

Testosterone F&T
Sensitive Estradiol (LC/MS)
DHEA
Prolactin
IGF-1
CBC
CMP (chemistries)
Sex Hormone Binding Globulin
Free t3

Jasen
What did you do to fix the issue?

 

[CoastWatcher]

Jasen
What did you do to fix the issue?

Jasen is affiliated with Defy Medical and was offering thoughts from a clinical perspective. It wasn't based on his own experience.

 

[100% PAUL]

Jasen is affiliated with Defy Medical and was offering thoughts from a clinical perspective. It wasn't based on his own experience.

I am aware of that. What does that have to do with what he did to fix the problem of the person who had gynecomastia even though E2 and prolactin were low

 

[CoastWatcher]

I am aware of that. What does that have to do with what he did to fix the problem of the person who had gynecomastia even though E2 and prolactin were low

It read as if you were asking for Jasen's personal experience. I felt that, in light of it being a somewhat older post, you should be aware of that.

 

[johndoesmith]

There is a theory called the Testosterone to Estrogen ratio. Basically, it takes into account the fact that men need a certain amount of both T and E2 and that more important than a static number for each of them is the ratio between the two. Young healthy men have a T:E ratio of between 14 and 20. So for example if you had an E2 of 30 and a Total T of 600, your T:E ratio would be 20.

This concept is logical when you think about it and it helps show why striving toward a specific number on a test can be futile. For example, a lot of guys want to get their E2 to be right at, lets use 30 again. Well, if they have a Total T of 900 or 1000, which would be common on TRT, their ratio is blown out of the water and that E2 number is way too low for those Total T levels. With a Total T of 900 and an E2 of 30, the T:E ratio is 30, and for a Total T of 1000 and an E2 of 30 the T:E ratio is 33.3.

Now there is always the exception - say the guy that is super sensitive to E2 and that needs a lower E2 level than most guys to feel good - but by and large the T:E ratio is a handy guideline and helps one to get past chasing his tail trying to get to a set number on a blood test.

I don't know if you'll see this as it's an older post.

My T to E2 ratio is 33 now. Total of 1188, and sensitive E2 of 36. NO AI.

I understand that's pretty low. What can one even do about that?

 

[CoastWatcher]

I don't know if you'll see this as it's an older post.

My T to E2 ratio is 33 now. Total of 1188, and sensitive E2 of 36. NO AI.

I understand that's pretty low. What can one even do about that?

The ratio is one value, not a hard-and-fast rule. It's one thing a patient and doctor can use to evaluate a protocol. The most important question is, how are you feeling? Any symptoms that would lead you to think your estradiol is in need of attention?