There seems to be mixed thoughts on whether it can cross the blood-brain barrier when taken directly. I’d say it’s so inexpensive that it wouldn’t hurt to try, and I tend to think that it would help. Earlier I referenced Andrew Huberman, and his suggested stack for sleep is magnesium threonate, apigenin, and theanine. I generally recommend adding one thing at a time so that would still be my suggested approach here, but he says they have a synergistic/compounding effect which really helps when stacked.
That being said, I would also recommend the advice above about lowering your dose. TRT can really wire up the nervous system, and if you’re getting hot flashes at night it could indicate a hormonal issue. I know a lot of people here(myself included which I try to refrain from) always want to solve a problem by adding a solution in the form of a supplement or action to their routine. But if something is off with your body you should listen to it and try to figure out what it is instead of trying to cover it up or add yet another ingredient to the ever-growing list. Perfect example is anti-depressants or painkillers. If you’re depressed it’s probably because of your lifestyle, diet, job, etc. Instead of taking a pill you should work to fix your life first. Same with painkillers. If you’re doing something that keeps you in pain then shutting down the pain signals may bring relief but in the long run will be worse for you than resolving the issue at its core. And yes, I know people deal with chronic pain or chemical imbalances so those drugs can be literal life-savers in some situations, but I think too many people jump to the quick fix first. So yeah…to avoid even more ranting/rambling…try slowly dropping your dose down and see if it helps resolve the issue. It’s quite possibly just a case of you mr body going “hey man, we’re not made to deal with these levels…especially at night”.