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I think I mostly agree with you, but when you say normal levels shouldn't cause harm, how we define normal is important. For example, my baseline free T was about 11 ng/dl and then i sent it up over 20+ ng/dl with some cream and my stomach started acting up. I might still have been in the normal range (barely), but normal for who? Not normal for me if my body likes to sit at 11.

Talking about benefits for most people that certain vulnerable types can't handle, if testosterone increases gastric acid secretion like it did in those rats, that could explain some of the experiences we're having.

We know there are tradeoffs inherent with increased testosterone because otherwise we would have evolved to have more. Maybe it sends more amino acids to the skeletal muscles instead of repairing the gut, the way it depletes your iron stores by directing all of it to RBC production. Testosterone certainly cranks up some people into a wired state with elevated HR, BP, insomnia, etc that doesn't seem conducive to the parasympathetic rest & digest program that normally maintains gut health. Just spitballing random ideas here but you get the picture that something like this could be involved.
That’s a great point about higher test levels possibly leading to the body being in a sympathetic state more of the time than if that same person had lower test levels. Being in a parasympathetic state is extremely important for things like digestion and healing. So it would make sense that if higher test levels caused a person to be in a sympathetic state more of the time, healing in certain areas could be effected. Not all areas tho, I would assume. Since testosterone can increase healing/ regeneration in things like skin, muscle and bone.

and that’s another great point in regards to the possibility of increased testosterone levels partitioning nutrients and resources differently/ using up certain nutrients more in order to increase some of the bodies actions, like how testosterone can cause iron stores to deplete faster since testosterone increases RBC production at a greater rate than men with lower testosterone levels. There absolutely could be trade offs to consider with testosterone, and like u said, everyone‘s body is going to function optimally at different levels.

But what matters most, imo, is anecdotal/ real world results. Clearly if u and @Belekas saw gastrointestinal issues when u raised ur test dosages, there’s definitely something going on here. The exact mechanism of action tho is hard to say. That study u posted at least offers a possible answer to what could be going on tho. So thanks for posting it
 
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A 130kg bb dude with a severely thick blood does phlebotomy himself and lets 1.5L blood straight into the motherfucking plastic bottle lmao The blood so thich it barely drips from the bottle when turned upside down smh I hear some crazy stories from time to time from back home, imagine that lol What high HTC? I knew folks do it themselves but 1.5L at once fuck me lol
 
ACR urine test = 0.2 mg/mmol
Urine Creatinine = 19.5 mmol/L
Urine Albumin = 4.8 mg/L

So as I understand from all the guidelines ACR < 3 mg/mmol is all good and no concert FWIW. Last year when I was eating my normal diet incl grains, fruits and vegs my Urine Creatinine was 1.4 mmol/L thats quite a jump to 19.5 now on eating mostly Beef. But given all the parameters last years ACR was 2.5 mg/mmol

Not sure what to make from it but seems the lower ACR ratio the better kidney health from what I've read. I might have gotten it wrong so please correct me if anyone sees a mistake I've made in my thinking. But anyway what a drastic change from last year to this year FWIW.


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Yeah that is really interesting. I wonder what effect an AI would have on the digestive side effects of TRT, especially GERD if estradiol relaxes the lower esophageal sphincter. Might be something to try for science at some point.
 
Beef itself has a lot of creatine, so that could account for the elevated creatinine. Also, for kidney health in general, astragalus and baking soda are two things to look into that may be helpful/protective, although it doesn't look like you have an issue. The carnivore people (e.g. Dr. Shawn Baker and Dr. Paul Saladino) have written on the lack of beef being an issue for the kidneys.
 
Yeah that is really interesting. I wonder what effect an AI would have on the digestive side effects of TRT, especially GERD if estradiol relaxes the lower esophageal sphincter. Might be something to try for science at some point.
Absolutely. I will ask my mate for a couple tablets and get them shipped to me with all the other meds I'm getting soon and will give it a go. I never researched them so not sure which ones to ask for Arimidex or Aromasin or shouldn't be a big difference?
 
Beef itself has a lot of creatine, so that could account for the elevated creatinine. Also, for kidney health in general, astragalus and baking soda are two things to look into that may be helpful/protective, although it doesn't look like you have an issue. The carnivore people (e.g. Dr. Shawn Baker and Dr. Paul Saladino) have written on the lack of beef being an issue for the kidneys.
Yes agree and thats the main difference since last years test which was pre TRT and eating a simple diet without restricting any food groups. This test the difference is I'm on TRT and have eaten mostly Beef for 2-3 weeks into the test FWIW. No carbs, no vegs, fruits, just meat, mostly Beef and some cheese here and there. I have Shawn Bakers book but yet to start. Been too deep into solving this H Pylori/Inflammed stomach lining/GERD issues.
 
Also, GHRP 6 is something to look into for GERD as it apparently speeds intestinal motility and gastric emptying. I have heard anecdotal reports of it being helpful.
Thats very interesting. I'm in the UK and just checked UK-peptides have GHRP 6 and it costs 9.95 for 5mg.
 
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View attachment 34757Got these results today and GP ordered ACR urine test for kidney health. I need Cystatin-C done as well as Creatinine and eGFR are not precise for a muscular and hard training person I believe. What are your opinion guys? Also was severely dehydrated during the blood test and have walked probably 10km almost fasted, so maybe that had impact as on results too. Will increase water as well as I eat a lot of protein and Kidneys are taking a toll.
Cystatin C
 
Also, GHRP 6 is something to look into for GERD as it apparently speeds intestinal motility and gastric emptying. I have heard anecdotal reports of it being helpful.
Have you heard anything about ipamorelin? That's also supposed to be a ghrelin-mimetic. Defy doesn't offer GHRP-6 but they do have ipamorelin so I'm thinking of trying that for the digestive gains.

Some places are advertising that it doesn't increase appetite or weight gain but reddit says that's a lie. It would need to be activating the ghrelin receptors and increasing appetite for it work for my purposes so hopefully reddit is correct.
 
GHRP-6 was one peptide that was never approved for compounding. It is also known to produce excess hunger, so as with everything else, minimum effective dose is key, although some people (like me) have, if anything, too little hunger, so you will have to experiment. I've never used it but I have used Ipam and I noticed no increase in hunger although it might still have an intestinal benefit, but GHRP 6 is the thing to start with.
 
GHRP-6 was one peptide that was never approved for compounding. It is also known to produce excess hunger, so as with everything else, minimum effective dose is key, although some people (like me) have, if anything, too little hunger, so you will have to experiment. I've never used it but I have used Ipam and I noticed no increase in hunger although it might still have an intestinal benefit, but GHRP 6 is the thing to start with.
Sounds good, I got both and will start with the GHRP-6. Any tips for dosage?
 
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Sounds good, I got both and will start with the GHRP-6. Any tips for dosage?
I haven't used GHRP-6, however my observation is that most dosages you will read about are probably way too high. It is apparently widely used by people (such as weight-class athletes) who are trying to gain weight, so I would start on the low end of the spectrum.
 
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