The Psychedelic Revolution Is Coming

[Nelson Vergel]

MindMed Collaborators Announce Positive Topline Data from Phase 2 Trial of Lysergide (LSD) in Major Depressive Disorder (MDD) - MindMed

– Primary endpoint achieved statistically significant improvement in MDD symptoms – – Confirmation of activity of lysergide in brain health disorders with direct relevance to MindMed’s MM-120 program in Generalized Anxiety Disorder (GAD) – – Data presented on April 14, 2023 in Basel, Switzerland...

mindmed.co

 

[mooseman109]

My wife prescribes ketamine and spravato daily

 

[Nelson Vergel]

Ketamine IV is very effective (and quick) in bringing some people peace in turmoil.

 

[mooseman109]

She has tremendous results with her patients. They keep the clinic full daily

 

[Nelson Vergel]

"Patients also had “significantly reduced” functional impairment using the Sheehan Disability Scale, with a p-value of 0.0271. MAPS said there were no serious adverse events in either the placebo or on-treatment group.

In addition, 71.2% of participants who received MDMA-assisted therapy no longer met the diagnostic criteria for PTSD at the end of the study, based on the Clinician-Administered PTSD Scale. That’s in comparison to 47.6% of participants on placebo.

And 46.2% of patients met the remission criteria in the MDMA-assisted group, compared to 21.4% in the placebo."

MAPS plans to seek approval of MDMA-assisted therapy this year after second positive PhIII trial

MAPS Public Benefit Corporation is touting another set of promising Phase III results investigating its MDMA-assisted therapy for post-traumatic stress disorder (PTSD), with the trial hitting primary and secondary endpoints as the organization prepares for an NDA filing this year. The trial...

endpts.com

 

[Deleted member 43589]

Just to think, back in the late 60's and early 70's we were all pioneers in therapy.

 

[DorianGray]

Just to think, back in the late 60's and early 70's we were all pioneers in therapy.

I had no need for any therapy back then or now. But if it existed, I tried it. Just to be sure I didn't need it.

 

[DorianGray]

Recent paper on the medical use of the hallucinogen:

Single-Dose Psilocybin Treatment for Major Depressive Disorder

This randomized clinical trial examines the timing of onset of action, durability of benefit, and safety profile of single-dose psilocybin in patients with major depressive disorder compared with placebo.

jamanetwork.com

 

[Nelson Vergel]

I wish I had the chance to expose my two sisters to the before they committed suicide.

 

[BadassBlues]

"It’s been a long, strange trip"

I have a good friend who married a woman who is considered to be a shaman, whatever that may actually mean. Not to be negative, I just don't know the validity of such things I guess.

She has given low dose psilocybin to several people I know as well as other psychedelics. The treatments are guided by her to ensure a positive experience. Rave reviews by all. I remain a bit skeptical, but am open to real scientific studies to validate any real benefits.

 

[Gman86]

"It’s been a long, strange trip"

I have a good friend who married a woman who is considered to be a shaman, whatever that may actually mean. Not to be negative, I just don't know the validity of such things I guess.

She has given low dose psilocybin to several people I know as well as other psychedelics. The treatments are guided by her to ensure a positive experience. Rave reviews by all. I remain a bit skeptical, but am open to real scientific studies to validate any real benefits.

It’s important to be skeptical. But everything revolves in a balance system. Being too skeptical can hurt u just as much as not being skeptical enough. Similar to how caring too much what people think of u has just as many downsides as not caring enough. Caring what people think of u is important, to a degree. But just listened to this podcast yesterday. She’s a lady that’s also advocating for what u want. Legitimate studies done on the benefits of psychedelics. Check it out if u want. I’ll leave the info for ya

https://spotify.link/VKrQHwm16Cb

 

[Deleted member 43589]

I wish I had the chance to expose my two sisters to the before they committed suicide.

WOW! I feel your pain Nelson, I lost my only brother to suicide too.

Some of you guys may not be old enough to know some of the more colorful history of research into mental illness using psychoactive drugs. Way back in the late 50's Dr. Richard Alpert and Dr. Timothy Leary, who both worked at Harvard University teamed up to start the Harvard Psilocybin Project. Ironically Timothy Leary became known as the father of the psychedelic movement of the 1960s. Both Leary and Alpert sought to document psilocybin's effects on human consciousness by administering it to volunteer subjects and recording their real-time descriptions of the experience. They believed that psilocybin could be the solution for the emotional problems of the Western man.

That same year, writer Ken Kesey volunteered to take part in a CIA study of the effects of psychedelic drugs, in particular LSD. The CIA's experiments with LSD were all part of The MK-Ultra program seeking to find out of LSD could be weaponized to control human behavior during the Cold War. Kesey ended up stealing a lot of the CIAs supply of LSD and started giving it to friends in San Francisco kick starting a huge counter culture which actually wound up fueling a generational rebellion that was dedicated to destroying everything that the CIA held dear and defended. Ironic huh?

Before that, novelist Aldous Huxley took mescaline under the direct supervision of psychiatrist Humphry Osmond. Osmond was one of a small group of psychiatrists who pioneered the use of LSD as a treatment for alcoholism and various mental disorders. Between the years of 1950 and 1965, some 40,000 patients had been prescribed one form of LSD therapy or another as treatment for neurosis, schizophrenia and psychopathy. It was even prescribed to children with autism.

70 years later we are still experimenting with psychedelics in hope of solving the emotional problems of Western man.

 

[BadassBlues]

It’s important to be skeptical. But everything revolves in a balance system. Being too skeptical can hurt u just as much as not being skeptical enough. Similar to how caring too much what people think of u has just as many downsides as not caring enough. Caring what people think of u is important, to a degree. But just listened to this podcast yesterday. She’s a lady that’s also advocating for what u want. Legitimate studies done on the benefits of psychedelics. Check it out if u want. I’ll leave the info for ya

https://spotify.link/VKrQHwm16Cb

Thanks for the info! I am open to any new ideas that have merit. I grew up in the 70's when drug use was widespread, so I have some predispositions that still cloud my judgement on the issue. Not that I didn't partake in any of those things...

 

[BadassBlues]

WOW! I feel your pain Nelson, I lost my only brother to suicide too.

Some of you guys may not be old enough to know some of the more colorful history of research into mental illness using psychoactive drugs. Way back in the late 50's Dr. Richard Alpert and Dr. Timothy Leary, who both worked at Harvard University teamed up to start the Harvard Psilocybin Project. Ironically Timothy Leary became known as the father of the psychedelic movement of the 1960s. Both Leary and Alpert sought to document psilocybin's effects on human consciousness by administering it to volunteer subjects and recording their real-time descriptions of the experience. They believed that psilocybin could be the solution for the emotional problems of the Western man.

That same year, writer Ken Kesey volunteered to take part in a CIA study of the effects of psychedelic drugs, in particular LSD. The CIA's experiments with LSD were all part of The MK-Ultra program seeking to find out of LSD could be weaponized to control human behavior during the Cold War. Kesey ended up stealing a lot of the CIAs supply of LSD and started giving it to friends in San Francisco kick starting a huge counter culture which actually wound up fueling a generational rebellion that was dedicated to destroying everything that the CIA held dear and defended. Ironic huh?

Before that, novelist Aldous Huxley took mescaline under the direct supervision of psychiatrist Humphry Osmond. Osmond was one of a small group of psychiatrists who pioneered the use of LSD as a treatment for alcoholism and various mental disorders. Between the years of 1950 and 1965, some 40,000 patients had been prescribed one form of LSD therapy or another as treatment for neurosis, schizophrenia and psychopathy. It was even prescribed to children with autism.

70 years later we are still experimenting with psychedelics in hope of solving the emotional problems of Western man.

As a person who grew up in the 60's and 70's, I did my share of some of the drugs that were popular in that era. I always stayed away from LSD and any of the hard stuff however. LSD scared the Hell out of me to be honest.

I did partake of mushrooms on occasion and have to say I really enjoyed it. Here is a short story of one of those times...

It was a Wednesday and I was off work. I was a craps dealer in Las Vegas at the time. I was just sitting around the house, bored and looking for something to do. A friend had given me some freeze dried mushrooms, so I decided to give it a whirl. I took a healthy amount and decided to go see a movie. Raiders of the Lost Ark had just come out, so I chose to see that. If anyone here has never done mushrooms before, let me tell you it takes a bit for them to kick in.

So I get to the theatre, and I was the only one there, seriously! It was odd. I had the whole place to myself. I sat right in the middle and put my feet up on the seat in front of me. The movie started, and the shrooms kicked in. The opening scene of Raiders is wild, I was tripping balls. To say this was a rush is an understatement. I thoroughly enjoyed myself.

I still think back on that every time I watch that movie.

 

[Nelson Vergel]

Combining DMT with SSRIs Bolsters DMT's Efficacy in Treating Severe Depression

The psychedelic renaissance movement was ignited by the idea that classical psychedelics like psilocybin, MDMA, LSD and DMT are potentially more effective

psychedelicspotlight.com

 

[Nelson Vergel]

I recommend that anyone who wants to do psychedelic assisted therapy do so with a MAPS trained therapist.

Here is a directory

Psychedelic Integration List - MAPS

integration.maps.org

 

[Nelson Vergel]

Oregon launches legal psilocybin access amid high demand and hopes for improved mental health care

Oregon has taken an unprecedented step in offering psilocybin, also known as magic mushrooms, to the public.

apnews.com

 

[Nelson Vergel]

Great article that summarizes current research

Psychedelic treatments are speeding towards approval — but no one knows how they work

Many questions remain about the formerly taboo chemicals that are being used to treat trauma and depression.

www.nature.com

 

[Deleted member 43589]

Beware of those who are out there pretending to be experts in administering psychedelic treatments.

Westminster Man Indicted for Distribution of a Controlled Substance Resulting in Death

DENVER – The United States Attorney’s Office for the District of Colorado announces that Ameen Alai, age 49, of Westminster, has been indicted on one count of distribution of ibogaine, a Schedule I controlled substance, resulting in death.

www.justice.gov

According to the indictment, on or about March 19, 2021, the defendant, Ameen Alai, also known as “Adam Powars,” knowingly and intentionally distributed a mixture and substance containing a detectable amount of ibogaine, the use of which resulted in the death of an individual on or about March 19, 2021.

Ibogaine is a naturally occurring psychoactive substance found in plants in the family Apocynaceae such as Tabernanthe iboga, Voacanga africana, and Tabernaemontana undulata. It is a psychedelic with dissociative properties. Preliminary research indicates that it may help counter drug addiction. One of the side effects of ibogaine is death.

Ameen Alai "The Guru" was charging anywhere from $10,000 - $50, 000 for this treatment.

 

[BadassBlues]

Beware of those who are out there pretending to be experts in administering psychedelic treatments.

Westminster Man Indicted for Distribution of a Controlled Substance Resulting in Death

DENVER – The United States Attorney’s Office for the District of Colorado announces that Ameen Alai, age 49, of Westminster, has been indicted on one count of distribution of ibogaine, a Schedule I controlled substance, resulting in death.

www.justice.gov

According to the indictment, on or about March 19, 2021, the defendant, Ameen Alai, also known as “Adam Powars,” knowingly and intentionally distributed a mixture and substance containing a detectable amount of ibogaine, the use of which resulted in the death of an individual on or about March 19, 2021.

Ibogaine is a naturally occurring psychoactive substance found in plants in the family Apocynaceae such as Tabernanthe iboga, Voacanga africana, and Tabernaemontana undulata. It is a psychedelic with dissociative properties. Preliminary research indicates that it may help counter drug addiction. One of the side effects of ibogaine is death.

Ameen Alai "The Guru" was charging anywhere from $10,000 - $50, 000 for this treatment.

I would say that death is an unacceptable side effect...