Renal Protection of Metformin

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madman

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Join host Chase Hendrickson, MD, from Vanderbilt University Medical Center, in a discussion about a recent article in The Journal of Clinical Endocrinology & Metabolism providing data in support of metformin being renal protective. He talks with Steven D. Wittlin, MD, from the University of Rochester Medical Center and guest expert Silvio Inzucchi, MD, medical director of the Yale Medicine Diabetes Center. The article featured this month, by Wang et al, was first published online in JCEM in July 2024: “Renal Protective Effect of Metformin in Type 2 Diabetes Patients.”
 
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Table 1. Metformin management in patients with T2DM with stage 3A, 3B, and 4 CKD.​

CKD stage

eGFR (mL·min-1·1.73 m-2)

Recommended daily dose

3A​

45-59​

0.5 g in the morning + 1 g in the evening​

3B​

30-44​

0.5 g in the morning + 0.5 g in the evening​

4​

15-29​

500 mg in the morning​


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