Low Total T and Normal Free T. Became hyper sensitive after HCG

[Willyt]

5mg per week? I'm all for micro dosing, but that is extreme. I have found that 6mg of Enanthate daily is low as I can go and still get some benefit from the TRT

 

[Willyt]

I recently read somewhere that the cutoff for shutting down LH production is about 9mg per day, that means, at least theoretically, below 9mg/day of exogenous T, some LH and testicular function is maintained, although I'm not sure if its contribution would have any clinical value.

Where did you read this? Many of us low dose guys can confirm that even small amounts (well below 9mg per day) shut down LH.
I would agree that there are degrees of HTPA suppression - i.e., 200mg per week versus 50mg per week - although even that is debatable

 

[aneuman]

Where did you read this?

Trying to find it now. Unfortunately, I don't always bookmark interesting things I read, mostly depending on where I read them.

I may have read it wrong though, or maybe it was 6 mg. I can't recall now. As soon as I (and if) I find the article I'll post it here

Many of us low dose guys can confirm that even small amounts (well below 9mg per day) shut down LH.

That was my understanding as well prior to reading this, but I must have been hallucinating. As a large language model, I'm not able to recall where the hell I got that info...

I would agree that there are degrees of HTPA suppression - i.e., 200mg per week versus 50mg per week - although even that is debatable

Sure

 

[aneuman]

Trying to find it now. Unfortunately, I don't always bookmark interesting things I read, mostly depending on where I read them.

I may have read it wrong though, or maybe it was 6 mg. I can't recall now. As soon as I (and if) I find the article I'll post it here

This was NOT the article I remember, but it points in a similar direction

Dose-related depression of both LH and FSH was observed subsequent to administration of 5 or more mg of testosterone per day; the smallest dosage (1 mg) was not associated with any consistent changes in LH or FSH.

Regulation of human gonadotropins. VIII. suppression of serum LH and FSH in adult males following exogenous testosterone administration

For what it's worth, this what chatGPT says:

In general, higher doses of exogenous testosterone are more likely to suppress LH and FSH production compared to lower doses. However, the specific threshold at which suppression occurs can vary among individuals. There isn't a universally agreed-upon dosage below which LH and FSH suppression reliably does not occur.

While I don't have access to real-time statistics or studies, it is generally recognized that lower doses of exogenous testosterone, particularly below 5 mg per day, are less likely to completely suppress LH and FSH production. However, it's important to note that even at lower doses, there may still be some degree of suppression, and long-term use can have cumulative effects on hormone production.

So I correct myself. It appears that statistically, it's generally recognized that at or above 5 mg per day, LH and FSH are likely start getting suppressed.

Apologies for the confusion. I will continue to look for the original article.

But always remember to take my advice: don't get advice from me.

 

[Willyt]

This was NOT the article I remember, but it points in a similar direction



Regulation of human gonadotropins. VIII. suppression of serum LH and FSH in adult males following exogenous testosterone administration

For what it's worth, this what chatGPT says:


So I correct myself. It appears that statistically, it's generally recognized that at or above 5 mg per day, LH and FSH are likely start getting suppressed.

Apologies for the confusion. I will continue to look for the original article.

But always remember to take my advice: don't get advice from me.

Many thanks for follow up. Even the 5mg level is very interesting. Was that with ester or without?

 

[aneuman]

Many thanks for follow up. Even the 5mg level is very interesting.

You're welcome.

Was that with ester or without?

I do not know, but my assumption (maybe incorrectly) is that this it is just testosterone, otherwise it would have said which ester or method they used, so if you translate to T.Cyp that would be the equivalent of approximately 7 mg of T.Cyp a day or 50 mg/week, which arguably could have a different effect than 5 daily. The supraphysiologic dosage the first couple of days is likely to exert a much more powerful inhibitory effect on the HPTG axis than 5mg every day.On the other hard, it took about 6 weeks I believe for total suppression of the Pituitary for men taking 125mg enanthate per week

Prior to the third administration of testosterone enanthate (125 mg), all s-LH concentrations were within the reference range (mean value 3.25±0.32 IU/L).

Effects of different doses of testosterone on gonadotropins, 25-hydroxyvitamin D3, and blood lipids in healthy men