Low dose enclomiphene combined with Low dose TRT

[Soalian]

Ok, I simply want to make sure for myself I don't jump straight into enclomiphene use without mapping out a viable cost/benefits ratio analysis.

 

[madman]

Would you provide the links? I'm interested in taking a look at the study conditions.

Thread 'Suppression of Serum LH and FSH in Adult Males following Exogenous Testosterone Suspension Administration (1972)'

Mar 1, 2025

* Samples of venous blood were obtained from 22 healthy adult males age 19-26 before and after the im injection of testosterone in aqueous suspension (Oreton©).


* The administration of the 12.5 and 25.0 mg of testosterone daily was reflected by markedly higher levels of serum testosterone. After the third dose of 25.0 mg, this level reached a peak within 16 hr after im administration and remained above control levels for at least 24 hr after the higher doses were administered. The rate of decline and the magnitude and duration of depression below...

• madman
• testosterone; gonadotropins; lh/fsh; hpta
• Replies: 2
• Forum: Testosterone and Men's Health Articles

 

[Cataceous]

Thread 'Suppression of Serum LH and FSH in Adult Males following Exogenous Testosterone Suspension Administration (1972)'

Mar 1, 2025

* Samples of venous blood were obtained from 22 healthy adult males age 19-26 before and after the im injection of testosterone in aqueous suspension (Oreton©).


* The administration of the 12.5 and 25.0 mg of testosterone daily was reflected by markedly higher levels of serum testosterone. After the third dose of 25.0 mg, this level reached a peak within 16 hr after im administration and remained above control levels for at least 24 hr after the higher doses were administered. The rate of decline and the magnitude and duration of depression below...

• madman
• testosterone; gonadotropins; lh/fsh; hpta
• Replies: 2
• Forum: Testosterone and Men's Health Articles

It doesn't really support the assertion by @aneuman of no suppression below 5 mg exogenous T per day.

FSH levels in 17 of 18 individuals receiving at least 5 mg testosterone per day were at or below prepubertal levels (4.59± 0.17) (13)​

...​

At no time were levels of LH and FSH higher after administration of testosterone than levels in the same individual before treatment. Thus, no evidence was obtained to indicate that testosterone in this dose range enhances release of LH or FSH. Moreover, except after 1 mg for 3 days, a suppressive influence of testosterone was observed regardless of dosage or duration of treatment.​

​

Three days is a pretty short trial. I suspect more suppression would occur over time.