Lab Results - Discussion of Free Estradiol

[stevep]

If you read through this thread I mentioned that my Primary had to draw additional vials for my CBC. For some reason they ran the Test and Estradiol Sensitive labs again. My original draw was at trough and the additional vials were drawn on a Tuesday the day after my injection. In earlier post you can see the difference between Test trough and peak.

What I find interesting about the Estradiol test I received today which was from the peak draw. Below is a table of the differences. I am surprised that the Anastrazole .125mg dose after my injections (M/Thr) make that big of a difference in my estradiol between trough and peak.


[TABLE="width: 410"]
[TR]
[TD]Testosterone[/TD]
[TD]Reference Range[/TD]
[TD="align: center"]4/10/2017
Trough[/TD]
[TD][/TD]
[TD="align: center"]4/18/2017 Peak[/TD]
[/TR]
[TR]
[TD]
Testosterone[/TD]
[TD]
205.00-781.00[/TD]
[TD="align: center"]
873.59[/TD]
[TD][/TD]
[TD="align: center"]
1056.85[/TD]
[/TR]
[TR]
[TD]
Testosterone, Calc. Free/Bioavailable (Adult Male 14+)[/TD]
[TD]
Reference Range[/TD]
[TD]

4/10/2017
Trough​

[/TD]
[TD][/TD]
[TD]

4/18/2017 Peak​

[/TD]
[/TR]
[TR]
[TD]
Free Testosterone, Percent[/TD]
[TD]
1.60-2.90[/TD]
[TD="align: center"]
1.76[/TD]
[TD][/TD]
[TD]

1.84​

[/TD]
[/TR]
[TR]
[TD]
Free Testosterone (calculation)[/TD]
[TD]

33-227​

[/TD]
[TD="align: center"]
154[/TD]
[TD][/TD]
[TD="align: center"]
194[/TD]
[/TR]
[TR]
[TD]
Testosterone Bioavailable

Sex Hormone Binding Globulin (SHBG)[/TD]
[TD="align: center"]
131-682[/TD]
[TD]

361​

51.0​

[/TD]
[TD][/TD]
[TD="align: center"]
455[/TD]
[/TR]
[TR]
[TD]
Estradiol, Free LC/MS/MS

Estradiol Free



Estradiol[/TD]
[TD]
Reference Range

< OR = 0.45 (pg/mL)

< OR = 29 (pg/mL)[/TD]
[TD]

4/10/2017
Trough​

.52​

24​

[/TD]
[TD][/TD]
[TD]

4/18/2017 Peak​

.30​

14​

[/TD]
[/TR]
[/TABLE]

 

[Vince Carter]

subjectively, are you at your best in that peak? Specifically with your Free E being down.

 

[sportsfan8724]

I find this to be very very interesting! It would be cool to have Dr. Saya comment of this too. Is it possible that those of twice weekly anastrozole actually have lower estradiol levels at peak and not trough because the anastrozole is peaking then?? If so would this mean we might be better testing estradiol at peak to get a better indication of the ai dose.

 

[stevep]

I know if I have too much estradiol then I don't get the night time erections which is an indicator things are/aren't in sync. When Defy put me an AI last January my free estradiol was .86 and I couldn't buy an erection.

So at .86 it's too high for me to function properly. My plumbing works at .52 and .30. I can't say I could tell any significant difference between .52 and .30.

 

[Vince Carter]

I can usually have overnite erections but it seems like most of those I have to have Cialis in my system, or they're weak/50% erections which is what I have during the day minus the PDE5i

 

[Gianluca]

Very nice thread guys, I just got to realize about the importance of testing Free T for us low SHBG guys, Doc Saya I'm wondering why we haven't done that test before? I'm really starting thinking that most of the trouble encountered after the first 10 months of my TRT were for too much E2 floating around, and for letting blood, that further increase my adrenal fatigue by depleting nutrients

Adding an AI would squeeze more Testosterone for the less conversion to E2, where would the squeezed T from AI go? would it add to TT and FT or just to TT?

 

[eyeheartny]

Has anyone been able to get more info on free estradiol? I just had a consult with Defy yesterday and we were discussing my relatively low SHBG (19.9 nmol/L, ref 16.5-55.9) on last test) and symptoms of high E2 (abdominal bloating/distension, constipation, water retention in face) and while my E2 sensitive test was at 27.7 pg/mL (ref 8-35), the PA at Defy suggested my free E2 may be too high for me to reduce some of these symptoms.

I used a spreadsheet I found on here and got an estimate of free E2 at 0.75 pg/mL based on my SHBG and albumin levels. I'm curious where any of you have found yourselves settling with free estradiol to feel good and eliminate/reduce symptoms of high E2 if you have low SHBG like me.