Is DHEA and Pregnenolone needed with TRT?

[nwolfe88]

Is it needed, or just a waste of time and money?

 

[magnus68]

I feel a difference in my mood and energy adding it

 

[Vince]

I do supplement with both. I have never felt anything from either of the two supplements.

Plus have never felt anything from estrogen.

 

[Phil Goodman]

Comes down to the individual. I feel better with low dose DHEA as part of my protocol(around 6 mg daily) but way worse with pregnenolone. The effects seemed to have changed after I started trt. Before, I could take 100 mg preg/day for weeks and not feel bad. Possibly some benefits, but it’s hard to tell because the effects are not as noticeable as other hormones. After starting trt though, even just 25 mg/day will result in much lower well-being and libido within a week. And it’s happened multiple times so I can attribute it to the pregnenolone. I should also add that I’d already started HCG with my trt regimen before re-introducing preg, so it’s possible that is the culprit and not the testosterone. Either way, something is happening with the pathways that causes myself(and a significant number of others) to experience negative sides from it when on trt. I know there are benefits of it supposedly, but for me it’s just not worth how I feel when taking it. And I’d also say there are other ways to get similar benefits. I’m pretty sure DHEA is the hormone that drops the most and fastest as we age though, and it also provides benefits/works as a standalone hormone in addition to producing downstream hormones, so to me it seems reasonable to supplement that one imho. But again I have to go pretty low dose or else I get too amped up and experience decline in sleep quality.

 

[nwolfe88]

Comes down to the individual. I feel better with low dose DHEA as part of my protocol(around 6 mg daily) but way worse with pregnenolone. The effects seemed to have changed after I started trt. Before, I could take 100 mg preg/day for weeks and not feel bad. Possibly some benefits, but it’s hard to tell because the effects are not as noticeable as other hormones. After starting trt though, even just 25 mg/day will result in much lower well-being and libido within a week. And it’s happened multiple times so I can attribute it to the pregnenolone. I should also add that I’d already started HCG with my trt regimen before re-introducing preg, so it’s possible that is the culprit and not the testosterone. Either way, something is happening with the pathways that causes myself(and a significant number of others) to experience negative sides from it when on trt. I know there are benefits of it supposedly, but for me it’s just not worth how I feel when taking it. And I’d also say there are other ways to get similar benefits. I’m pretty sure DHEA is the hormone that drops the most and fastest as we age though, and it also provides benefits/works as a standalone hormone in addition to producing downstream hormones, so to me it seems reasonable to supplement that one imho. But again I have to go pretty low dose or else I get too amped up and experience decline in sleep quality.

My plan is to drop them both for 6-12 weeks and retest bloodwork

 

[WhiteMale]

supplementing DHEA and/or Pregnenolone even at low doses like 2.5mg/D makes me very irritable. I cannot and do not use either one. As well HCG does nothing for me and is also not being used. A lot of trial and error over time to reach these conclusions, you just have to monitor yourself and limit the changes one at a time and see how you feel.

 

[Systemlord]

Is it needed, or just a waste of time and money?

Unless you’re deficient in any of these, the majority of the time supplements are a waste of money. People that do need supplements is due to being in an inflamed state from eating the wrong food.

 

[Phil Goodman]

Unless you’re deficient in any of these, the majority of the time supplements are a waste of money. People that do need supplements is due to being in an inflamed state from eating the wrong food.

How would you define “deficient” with these hormones, particularly DHEA.

Also, that is a drastically over-simplified statement that you ended the post with. Sure eating trash will probably lower levels more quickly and introduce many health problems, but even people who eat healthy and maintain a good lifestyle will see levels drop significantly over time.