Whenever you change your protocol whether it's a dosage change or frequency change, your body must adapt to the new change and it will takes 6 weeks for testosterone and estrogen to stabilize in the bloodstream, until then your levels will be fluctuating wildly and you will feel good off and on.
I increased my dosage 2 weeks ago and all my levels were sent into chaos and now have 4 more weeks before levels become stable, until then it's bouts of minor anxiety, feeling unwell, and even blood pressure fluctuations. As I get closer to 6 weeks I will start to notice I'm feeling better often as my levels become more and more stable as I near the 6 week mark.
I have SHBG on the lower end and inject 24mg every 2 days, otherwise estrogen is very high.