In the search for libido. Started Wellbutrin XL

[M.J]

The OP started the thread in hopes that starting Wellbutrin would help his libido. Wellbutrin works by increasing norepinephrine and dopamine levels.

Selegeline is at least related to Wellbutrin, and acts similarly. It also increases dopamine. And depending on the dose, can also increase norepinephrine and serotonin levels. It also has the added benefit of being and anti-aging drug. So it’s a pretty good alternative, imo, for anyone that’s considering a medication like Wellbutrin.

But we probably should get back to talking more about Wellbutrin specifically

I read high serotonin can cause delay ejaculation or something or delay actually and hurt libido. (You double check this but I saw it in YouTube) if anything you want less serotonin.

If Wellbutrin and Selegeline are related which one would be better ?

I am happy with Wellbutrin.

 

[M.J]

Exact same. Don’t think I’ve ever really noticed any distinct/ noticeable benefits from it, but I do like the anti-aging benefits it potentially offers, even if those are happening in the background without me noticing. Plus, mood and energy and sexual functions is pretty hard to assess, as far as what could be effecting what. So there’s a chance it does give me some positive benefits, when I do take it, but they’re just not drastic enough for me to associate them with the selegiline

what dose, route, and frequency are u thinking if u do end up taking it again?

So Wellbutrin and selegeline are the same ?

 

[M.J]

Update…….

today I forgot to take my Wellbutrin tablet. Felt a bit off specially in libido.

Will continue tomorrow.

 

[Gman86]

So Wellbutrin and selegeline are the same ?

So they’re similar in regards to some of the neurotransmitters they effect, but they’re pretty different in the way they do it

Wellbutrin inhibits the reuptake of norepinephrine and dopamine, leaving more of both in ur system, I believe

Selegiline is an enzyme blocker (MAO inhibitor) that works by slowing the breakdown of certain neurotransmitters. In lowish dosages, it only blocks the enzyme Monoamine oxidase B (MOA-B), which is involved in the process of breaking down dopamine, mainly. So by blocking this enzyme, less dopamine is destroyed, and therefore u have more dopamine in ur system. In higher dosages, or starts to not only block MAO-B, but MAO-A, which is involved in breaking down neurotransmitters such as serotonin, epinephrine, norepinephrine. So it’s a pretty interesting compound, as far as being able to control what neurotransmitters it effects, based on the dosage u take.

If I had to choose between the two, I would personally choose selegiline. Assuming both works similarly as far as symptom resolution goes. Just like how u can control the neurotransmitters it effects, plus I obv like that it supposedly has anti-aging benefits

as far as high serotonin goes, I’ve read/ heard the same exact thing. That it can effect libido negatively. It also can cause blunting of emotions. I’m definitely not convinced that increasing serotonin has any place when it comes to depression. Only benefit I can see from increasing serotonin, as far as depression goes, is the blunting of emotions. If someone is extremely depressed, and/ or suicidal, feeling emotionally flat could definitely be an improvement, I would assume.

if I had to take a medication for depression, I would definitely prefer to trial meds that increased dopamine levels, over ones that increase serotonin levels

 

[M.J]

So they’re similar in regards to some of the neurotransmitters they effect, but they’re pretty different in the way they do it

Wellbutrin inhibits the reuptake of norepinephrine and dopamine, leaving more of both in ur system, I believe

Selegiline is an enzyme blocker (MAO inhibitor) that works by slowing the breakdown of certain neurotransmitters. In lowish dosages, it only blocks the enzyme Monoamine oxidase B (MOA-B), which is involved in the process of breaking down dopamine, mainly. So by blocking this enzyme, less dopamine is destroyed, and therefore u have more dopamine in ur system. In higher dosages, or starts to not only block MAO-B, but MAO-A, which is involved in breaking down neurotransmitters such as serotonin, epinephrine, norepinephrine. So it’s a pretty interesting compound, as far as being able to control what neurotransmitters it effects, based on the dosage u take.

If I had to choose between the two, I would personally choose selegiline. Assuming both works similarly as far as symptom resolution goes. Just like how u can control the neurotransmitters it effects, plus I obv like that it supposedly has anti-aging benefits

as far as high serotonin goes, I’ve read/ heard the same exact thing. That it can effect libido negatively. It also can cause blunting of emotions. I’m definitely not convinced that increasing serotonin has any place when it comes to depression. Only benefit I can see from increasing serotonin, as far as depression goes, is the blunting of emotions. If someone is extremely depressed, and/ or suicidal, feeling emotionally flat could definitely be an improvement, I would assume.

if I had to take a medication for depression, I would definitely prefer to trial meds that increased dopamine levels, over ones that increase serotonin levels

I am doing good with Wellbutrin do you think I should give Selengeline a shot? instead of Wellbutrin ? Even my side affect are almost nothing. Actually even alcohol didn’t do much .

But addyi seems to add to this mixture a seretonin lowering component.
As I understood. Which theoretically could be better option than Wellbutrin. Planning to try it end of this year.

Again Wellbutrin defiantly helped my libido and I can’t see myself stopping it anytime soon

 

[BadassBlues]

I am going to start a dedicated thread on Selegeline. We can take the discussion there.

 

[FunkOdyssey]

I am doing good with Wellbutrin do you think I should give Selengeline l a shot? instead of Wellbutrin ? Even my side affect are almost nothing. Actually even alcohol didn’t do much .

But with they said addyi seems to add to this mixture a seretonin lowering component.
As I understood. Which theoretically could be better option than Wellbutrin. Planning to try it end of this year.

Again Wellbutrin defiantly helped my libido and I can’t see myself stopping it anytime soon

Not to give you any crazy ideas, but I did combine bupropion with selegiline back in the day. It took my robot-like motivation to the next level for awhile. I don't remember exactly what went wrong that caused me to stop. I had a good run though, on the two of them, for awhile.

 

[tareload]

Not to give you any crazy ideas, but I did combine bupropion with selegiline back in the day. It took my robot-like motivation to the next level for awhile. I don't remember exactly what went wrong that caused me to stop. I had a good run though, on the two of them, for awhile.

Bupropion XL 150 mg getting added to the escitalopram 10 mg daily. Hopefully I can get some terminator back for a while. Currently a zombie. A reasonably muscular zombie but still a zombie.

Weird that my workouts/workout motivation has been enhanced with escitalopram in contrast with professional output. I guess without having to worry about panic attacks I must feel like a kid in a candy store at the gym. Joints are getting pounded.

Work output has to improve soon.

 

[M.J]

I am going to start a dedicated thread on Selegeline. We can take the discussion there.

A couple of warning advices not to combine both,,, I am extremely carful with such products.

 

[Gman86]

I am doing good with Wellbutrin do you think I should give Selengeline l a shot? instead of Wellbutrin ? Even my side affect are almost nothing. Actually even alcohol didn’t do much .

But with they said addyi seems to add to this mixture a seretonin lowering component.
As I understood. Which theoretically could be better option than Wellbutrin. Planning to try it end of this year.

Again Wellbutrin defiantly helped my libido and I can’t see myself stopping it anytime soon

Nah I personally wouldn’t switch. Sounds like Wellbutrin is working pretty damn well for u, and I wouldn't risk messing with that if I were u

 

[M.J]

Update…

Been more than a month now.

Still See improvement in performance libido I would say 30% improvement.

Problems :

I still have sensitivity issue or not reaching orgasm easy. I would say it’s 10% better though.

I read that high serotonin can cause this(so addyi will be next)

Highlight:

But once I reach orgasm it’s is crazy high and intense.With the help of my hand of course :/

 

[M.J]

Update…..

past three days been low in libido, defiantly lower than before, I am annoyed with the fact I am not having morning wood and concerned it may affects me negatively.

 

[electrify]

So they’re similar in regards to some of the neurotransmitters they effect, but they’re pretty different in the way they do it

Wellbutrin inhibits the reuptake of norepinephrine and dopamine, leaving more of both in ur system, I believe

Selegiline is an enzyme blocker (MAO inhibitor) that works by slowing the breakdown of certain neurotransmitters. In lowish dosages, it only blocks the enzyme Monoamine oxidase B (MOA-B), which is involved in the process of breaking down dopamine, mainly. So by blocking this enzyme, less dopamine is destroyed, and therefore u have more dopamine in ur system. In higher dosages, or starts to not only block MAO-B, but MAO-A, which is involved in breaking down neurotransmitters such as serotonin, epinephrine, norepinephrine. So it’s a pretty interesting compound, as far as being able to control what neurotransmitters it effects, based on the dosage u take.

If I had to choose between the two, I would personally choose selegiline. Assuming both works similarly as far as symptom resolution goes. Just like how u can control the neurotransmitters it effects, plus I obv like that it supposedly has anti-aging benefits

as far as high serotonin goes, I’ve read/ heard the same exact thing. That it can effect libido negatively. It also can cause blunting of emotions. I’m definitely not convinced that increasing serotonin has any place when it comes to depression. Only benefit I can see from increasing serotonin, as far as depression goes, is the blunting of emotions. If someone is extremely depressed, and/ or suicidal, feeling emotionally flat could definitely be an improvement, I would assume.

if I had to take a medication for depression, I would definitely prefer to trial meds that increased dopamine levels, over ones that increase serotonin levels

Just to add, theres some debate nowadays whether MAO-B metabolizes dopamine at all. The wiki article on MAO-B mentions this and references this study Redefining differential roles of MAO-A in dopamine degradation and MAO-B in tonic GABA synthesis

MAO-B inhibition does increase DA indirectly though, because MAO-B metabolizes PEA. And PEA is like the body's natural amphetamine, releases DA and NE

 

[M.J]

updates….

Morning wood completely disappeared I am not getting any small reaction since I started Wellbutrin and this annoys me a lot. Only came back when having sex and going to bed.

I believe I had a honey moon period during the end of first month most likely related to my injections as sometimes I skip an injection due to my schedule.

Having said that Wellbutrin seems enhances libido by 20% but when that libido kicks in it’s in my opinion it’s very amplified,,when I reach orgasm I feel it extremely intense. This is %100 due to Wellbutrin.

I have love hate relation, love the enhancements in libido although it’s not enough but it elevate my flat feeling.

Hate and concerned about the health affect of not having morning wood.

Not sure but I think there is relation between no3 and antidepressant.

Started NMN today.

 

[tareload]

Added in bupropion XL a week ago at 150 mg on top of escitalopram that I have been using almost a year or so. Really only wanted to turn around Trash mood and anhedonia that comes with escitalopram.

This stuff is a raging boner in a bottle. No more so so TRT/TOT wood. Guess I will enjoy the honeymoon period while it lasts. It is nuts and libido boost as well.

 

[M.J]

Added in bupropion XL a week ago at 150 mg on top of escitalopram that I have been using almost a year or so. Really only wanted to turn around Trash mood and anhedonia that comes with escitalopram.

This stuff is a raging boner in a bottle. No more so so TRT/TOT wood. Guess I will enjoy the honeymoon period while it lasts. It is nuts and libido boost as well.

How is the morning wood ?

Even during my honey moons period I didn’t get morning wood which is not what I was used to.

 

[tareload]

How is the morning wood ?

Even during my honey moons period I didn’t get morning wood which is not what I was used to.

Yeah sure enough I am getting some which hasn't happened in many years since TRT. Weird and supports neurotransmitter hypothesis.

 

[FunkOdyssey]

How is the morning wood ?

Even during my honey moons period I didn’t get morning wood which is not what I was used to.

As others have mentioned elsewhere, you need to be waking up from REM sleep in order to experience morning wood. If you were in a different sleep stage when you wake, you won't have the wood, even if you are having nocturnal erections at other times of the night during REM phases.

So, the lack of morning wood on bupropion may just mean it is affecting your sleep, which seems very plausible to me, versus having some kind of erection suppressing effect.

 

[DixieWrecked]

updates….

Morning wood completely disappeared I am not getting any small reaction since I started Wellbutrin and this annoys me a lot. Only came back when having sex and going to bed.

I believe I had a honey moon period during the end of first month most likely related to my injections as sometimes I skip an injection due to my schedule.

Having said that Wellbutrin seems enhances libido by 20% but when that libido kicks in it’s in my opinion it’s very amplified,,when I reach orgasm I feel it extremely intense. This is %100 due to Wellbutrin.

I have love hate relation, love the enhancements in libido although it’s not enough but it elevate my flat feeling.

Hate and concerned about the health affect of not having morning wood.

Not sure but I think there is relation between no3 and antidepressant.

Started NMN today.

I tried nmn and didn't notice too much. I enjoy Niacin though. Works MUCH better at increasing NAD+ levels than nmn. I think it depends on your individual chemistry though.

Niacin Increases NAD+ Significantly in Human Trial |

Researchers have concluded a human trial using niacin, a very old vitamin discovered over 80 years ago, and have shown that it can increase […]

www.lifespan.io

 

[tareload]

As others have mentioned elsewhere, you need to be waking up from REM sleep in order to experience morning wood. If you were in a different sleep stage when you wake, you won't have the wood, even if you are having nocturnal erections at other times of the night during REM phases.

So, the lack of morning wood on bupropion may just mean it is affecting your sleep, which seems very plausible to me, versus having some kind of erection suppressing effect.

That is the other funny part. My sleep (which already was not great) has been hot trash since starting the bupropion. 20 point reduction in sleep score and REM sleep disappeared.