In the search for libido. Started Wellbutrin XL

[M.J]

Updates. After one month and few days of using Wellbutrin.

In summary I can’t stop using Wellbutrin it worked well.

Just to be accurate I feel I had an increase somewhere around 40% in desire, libido. It’s not the honey moon period but I am %100 sure it worked well. I started to think about moving my dose to less frequent (currently doing Eod) maybe twice a week but still thinking about it. ( just to improve quality of life by less injections)

Morning wood not so much but erection is better libido is better desire is much better I don’t feel flat anymore. I believe this will continue to be the case.
I had a crazy honey moon period 10 days ago which could be because some variation in my injection. Even that honey moon was crazyyyyy better than the normal honeymoon period feels like Wellbutrin increased my sense of feeling and desire by 50% or so even during honey moon periods.


Wellbutrin will still be part of my routine going forward.and I will keep updating…

Next plan is increase Wellbutrin but not after I trying addyi. Which planning to get from my next trip to New York late October.

 

[FunkOdyssey]

Updates. After one month and few days of using Wellbutrin.

In summary I can’t stop using Wellbutrin it worked well.

Not to be a Debbie downer, but the honeymoon period on a drug like Wellbutrin can be more like a few months than a few weeks. So I would try to reserve judgment on whether it deserves a permanent place in your regimen until several months down the road.

 

[M.J]

Not to be a Debbie downer, but the honeymoon period on a drug like Wellbutrin can be more like a few months than a few weeks. So I would try to reserve judgment on whether it deserves a permanent place in your regimen until several months down the road.

Totally agree. But my point is I had few days where it was crazy high. I guess it’s due to injections / protocol changes which I had sometimes for many reasons. BUT the main point the rest of time before and after is where I judged on it. Which is again an increase of around 40%.

Yet again let’s see if this stable increase will stay longer.

 

[BadassBlues]

Selegiline still on my radar (from another thread). Going to experiment with it at some point. I know there are lots mixed reviews out there.

Selegeline is an absolute wonder drug, but there are very specific and somewhat narrow parameters. The effects are age based and dosage dependent. Older people are the ones who reap the benefits of low dose (5mg) usage. Taken as a low dose, Selegeline targets just MAO-B. As a reuptake inhibitor it keeps dopamine active. As we age, dopamine levels decline. Taking a 5 mg dose of Selegeline daily keeps dopamine at more youthful levels. The result is more ambition, better mood, libido increase, alertness and an overall feeling of well being.

I have taken it as a younger person and now at 66. I take 5 mg daily and can report an extremely positive overall experience. Of course, this is only one facet of my anti aging regimen, but an effective one.

Younger people will find it varies by the individual, hence the mixed reviews.

 

[BadassBlues]

Wellbutrin works very well for some people. If you are prone to anxiety, it may be something that should be avoided. It has a greater affinity for norepinephrine than dopamine. I used to take it and had fairly good results. As for libido, it really varies on the person. Anxiety is a libido killer.

Libido is a complicated and highly variable subject. Very few drugs have a direct effect on libido. If a person is depressed with a lack of motivation and energy, taking a drug that increases those factors will likely result in a bump in libido.

Personally, I had to discontinue Wellbutrin due to anxiety and insomnia.

 

[Gman86]

Selegeline is an absolute wonder drug, but there are very specific and somewhat narrow parameters. The effects are age based and dosage dependent. Older people are the ones who reap the benefits of low dose (5mg) usage. Taken as a low dose, Selegeline targets just MAO-B. As a reuptake inhibitor it keeps dopamine active. As we age, dopamine levels decline. Taking a 5 mg dose of Selegeline daily keeps dopamine at more youthful levels. The result is more ambition, better mood, libido increase, alertness and an overall feeling of well being.

I have taken it as a younger person and now at 66. I take 5 mg daily and can report an extremely positive overall experience. Of course, this is only one facet of my anti aging regimen, but an effective one.

Younger people will find it varies by the individual, hence the mixed reviews.

U just take the 5mg orally? Not sublingually?

do u take it in the morning on an empty stomach?

 

[BadassBlues]

U just take the 5mg orally? Not sublingually?

do u take it in the morning on an empty stomach?

I take 5 mg orally in the AM on an empty stomach. I have never tried taking it sublingually, might just give that a go

 

[FunkOdyssey]

I take 5 mg orally in the AM on an empty stomach. I have never tried taking it sublingually, might just give that a go

Sublingual selegiline is like 8x stronger or something crazy like that so be careful.

 

[Gman86]

I take 5 mg orally in the AM on an empty stomach. I have never tried taking it sublingually, might just give that a go

Idk, sounds like what ur doing is working fantastic for u! Doesn’t hurt to experiment tho. At least u know u can always go back to taking 5mg orally everyday

like @FunkOdyssey said, bioavailability can be increased up to 8 times. So u definitely want to take less if ur gonna take it sublingually

have u tried different dosages throughout the years?

 

[BadassBlues]

Idk, sounds like what ur doing is working fantastic for u! Doesn’t hurt to experiment tho. At least u know u can always go back to taking 5mg orally everyday

like @FunkOdyssey said, bioavailability can be increased up to 8 times. So u definitely want to take less if ur gonna take it sublingually

have u tried different dosages throughout the years?

I did try 10 mg years ago, I actually wrote a very long thread about my experiences with it on ATM. That thread had a lot of studies and clinical information. I stopped taking it for a while and started back 2 years ago. This is a drug I will continue to take for the rest of my life. I may increase to 6 or 7 mgs as I get older, but any more than 10 and you begin to target the MAO-A receptors as well.

 

[Gman86]

I did try 10 mg years ago, I actually wrote a very long thread about my experiences with it on ATM. That thread had a lot of studies and clinical information. I stopped taking it for a while and started back 2 years ago. This is a drug I will continue to take for the rest of my life. I may increase to 6 or 7 mgs as I get older, but any more than 10 and you begin to target the MAO-A receptors as well.

Any way to link that long thread u mentioned? I would love to read it! I’ve been researching and taking selegiline off and on for years now. It’s definitely a fascinating compound

did u notice any negatives from taking 10mg/ day?

 

[Gman86]

Here’s one of my fav anecdotes that I have saved. Guy has been taking it for 32 years

doogiehowitzer1 1y

I’ve been taking selegiline in some form or another for 32 years now. Always in low doses varying between 1-5mgs. I am 41 years old now, and many people regularity comment on my youthful appearance.



-It is energizing and uplifting for me. Although I already have a naturally high tolerance to stimulants. It is very motivating and an aphrodisiac. It has certainly been a nootropic for me and aided me in my career. There have been strategy meetings where I would suddenly have bouts of creativity or insight which I feel would not have occurred if I hadn’t been taking it. But I can’t be certain if that’s placebo or not.

If you find it to be overly stimulating or creating other negative side effects back your dosing off to every other day or every 2-3 days. I have used varying dosing schemes over the years (always in doses less than <5mg.) I have settled on my preferred dose being 1mg sublingual every day or every other day depending on how I am feeling. I have never had a single negative effect that I can discern. I drink wine, eat whatever I want, have combined I with other stimulants in the past for whatever reason at the time. All good. I am in great health as well though. I run 5 days a week and lift weights 2 days weekly. I do credit selegiline with giving me the motivation and energy to continue working out like that.

I realize I may be an outlier. There are many reports in the Internet of selegiline working well initially for many only to cause problems which led to discontinuation later on. My belief is that most of these are due to taking too much. Dr Knoll himself advised a very conservative dosing regimen which is not being followed in these negative reviews.

 

[BadassBlues]

Any way to link that long thread u mentioned? I would love to read it! I’ve been researching and taking selegiline off and on for years now. It’s definitely a fascinating compound

did u notice any negatives from taking 10mg/ day?

The thread was on Dr. Crislers forum, ATM, which is now gone. When I was taking 10mg, I was a bit younger and had a more youthful and natural neurotransmitter balance. I was in my 40's. At 10mg, I experienced elevated mood, increased libido and was very "on task". I don't recall any negative side effects. It became temporarily hard to get, so I just stopped taking it. I now have a prescription for it.

I had a lot of mixed reviews on that thread. Some positive, and some negative. As I stated above, age and dosage are key factors. Most who try Selegeline do so without any research end up taking the wrong dose. They also have elevated expectations. If you are young with a good neurotransmitter balance, you may not notice much of an effect. It is highly variable based on individual chemistry. Also on the dosage. The key is to dial in the proper dose without exceeding the threshold where is becomes non selective for the MAO-B and begins to affect the MAO-A. MAO-A affects serotonin levels.

 

[Gman86]

The thread was on Dr. Crislers forum, ATM, which is now gone. When I was taking 10mg, I was a bit younger and had a more youthful and natural neurotransmitter balance. I was in my 40's. At 10mg, I experienced elevated mood, increased libido and was very "on task". I don't recall any negative side effects. It became temporarily hard to get, so I just stopped taking it. I now have a prescription for it.

I had a lot of mixed reviews on that thread. Some positive, and some negative. As I stated above, age and dosage are key factors. Most who try Selegeline do so without any research end up taking the wrong dose. They also have elevated expectations. If you are young with a good neurotransmitter balance, you may not notice much of an effect. It is highly variable based on individual chemistry. Also on the dosage. The key is to dial in the proper dose without exceeding the threshold where is becomes non selective for the MAO-B and begins to affect the MAO-A. MAO-A affects serotonin levels.

I agree. I have an endless amount of anecdotes saved from researching selegiline over the years. Mostly positive anecdotes, but I like to save some negative ones as well, in the hopes that I can see patterns between them and figure out if there’s anything they have been doing wrong, which ultimately resulted in them having a negative experience with the compound, that I can personally avoid, thus hopefully increasing my chance of success with it. And I’ve come to the same conclusion. In almost every negative review, they were taking too much. I, however, didn’t take their age into consideration. Sounds like age can be a decently strong indicator of how much the person should be taking, as far as selegiline goes.

Like u said, Dr. Knolls recommended a very low dosage, when taking selegiline. At least for longevity purposes. I believe his recommendation was 1mg 2x/ week, and that was orally. A lot of guys end up taking dosages around 1.25mg, either daily, or EOD, sublingually. And if taking it sublingually can increase absorption/ bioavailability by 8x, that would mean that guys taking these dosages, at this frequency, would be taking around the equivalent of 10mg orally ED or EOD, which is a far cry from the 2mg per week Dr. Knolls recommended.

 

[Guided_by_Voices]

Any way to link that long thread u mentioned? I would love to read it! I’ve been researching and taking selegiline off and on for years now. It’s definitely a fascinating compound

did u notice any negatives from taking 10mg/ day?

If you have access to the Wayback Machine it should be there. Someone else posted another classic ATM thread here that they pulled from it (Ultimate Adrenergic Control of Erections). If you find it please post it as a separate thread. There's a lot of topic sliding going on here these days.

 

[BadassBlues]

If you have access to the Wayback Machine it should be there. Someone else posted another classic ATM thread here that they pulled from it (Ultimate Adrenergic Control of Erections). If you find it please post it as a separate thread. There's a lot of topic sliding going on here these days.

That was a long lived thread! Thierry was the OP on that one. If I happen to locate the thread, I'll post it separately.

 

[Gman86]

If you have access to the Wayback Machine it should be there. Someone else posted another classic ATM thread here that they pulled from it (Ultimate Adrenergic Control of Erections). If you find it please post it as a separate thread. There's a lot of topic sliding going on here these days.

The OP started the thread in hopes that starting Wellbutrin would help his libido. Wellbutrin works by increasing norepinephrine and dopamine levels.

Selegeline is at least related to Wellbutrin, and acts similarly. It also increases dopamine. And depending on the dose, can also increase norepinephrine and serotonin levels. It also has the added benefit of being and anti-aging drug. So it’s a pretty good alternative, imo, for anyone that’s considering a medication like Wellbutrin.

But we probably should get back to talking more about Wellbutrin specifically

 

[Guided_by_Voices]

The OP started the thread in hopes that starting Wellbutrin would help his libido. Wellbutrin works by increasing norepinephrine and dopamine levels.

Selegeline is at least related to Wellbutrin, and acts similarly. It also increases dopamine. And depending on the dose, can also increase norepinephrine and serotonin levels. It also has the added benefit of being and anti-aging drug. So it’s a pretty good alternative, imo, for anyone that’s considering a medication like Wellbutrin.

But we probably should get back to talking more about Wellbutrin specifically

I'm glad it was mentioned because I need to get back in the habit of taking some. I never really noticed anything but I will restart it.

 

[Gman86]

I'm glad it was mentioned because I need to get back in the habit of taking some. I never really noticed anything but I will restart it.

Exact same. Don’t think I’ve ever really noticed any distinct/ noticeable benefits from it, but I do like the anti-aging benefits it potentially offers, even if those are happening in the background without me noticing. Plus, mood and energy and sexual functions is pretty hard to assess, as far as what could be effecting what. So there’s a chance it does give me some positive benefits, when I do take it, but they’re just not drastic enough for me to associate them with the selegiline

what dose, route, and frequency are u thinking if u do end up taking it again?

 

[Guided_by_Voices]

I was taking 1mg orally every few days. I respond well to small doses of most things.