I got on 8 years ago via a family doc. I was just under 300 total T. Like Charliebizz I had pre existing anxiety issues which had been pretty well under control for years on 50 mg of Zoloft. After a few months the anxiety increased dramatically. At first i tried other SSRIs, etc with no effect. You have to understand this was 8 years ago and the information available now was not as widespread then. I did it all, AI, no AI, HCG, low dose, split dose, two different doctors out of state that are recognized as experts in the field, etc. The second doctor was the FIRST one who actually said exogenous Test can increase anxiety in predisposed individuals. I won't share his name, but he is one of the less vocal ones on the former TOT roundtable. He recommended trying to come off. After 3 months with my T only at 350 he wasnt optimistic it would work. We tweaked a few things and In making the best of it.