Estradiol and DHT increases plateau at higher doses of testosterone

[Nelson Vergel]

We found that during administration of graded doses of TE, the older men had higher total and free E2 concentrations and higher total and free E2:T ratios than young men after adjusting for serum testosterone levels. In contrast to E2 levels, serum DHT levels and DHT:T ratios did not differ between young and older men. Regression modeling revealed that percentage fat mass independently and partly explained the difference in free E2 levels between young and older men, and jointly with SHBG explained most of the differences in free E2 levels as well as free E2:T ratios in the two groups. There also was an apparent effect of testosterone dose on metabolite to testosterone ratios; higher doses of testosterone were associated with seemingly lower metabolite to testosterone ratios in both young and older men.

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2913038/

 

[Werewolf]

Confused

Nelson,

I'm a bit confused by the title of your thread in relation to the study.

When I look at the tables, E2 and DHT seem to increase in a fairly linear fashion with higher doses but your title says that they plateau?