If you changed from 20 mg EOD to 50 mg E3.5D then that's going from 70 mg/week to 100 mg/week, almost a 50% increase. Nonetheless, I think there is something to be said for hormone fluctuations, and I've been experimenting with this for the last year. My hypothesis is that fluctuations over longer periods of time, e.g. a week, can be problematic because they allow for greater peak estradiol than daily fluctuations. I have found that daily propionate provides fluctuations greater than those found in natural men, meaning a small amount of a longer ester should be added to achieve the most natural result. However, injections cause a very fast rise in testosterone, hitting a peak within two to four hours. This pattern is rather different from the semi-sinusoidal variation seen in natural men.