Difference between daily IM vs daily SubQ?

[GreenMachineX]

Some men see substantially lower total and free testosterone with subq and higher E2, while some men do not. The percentage affected negatively is not clear. The only study to capture this effect was one of the Xyosted studies comparing xyosted to enanthate IM - other studies have not replicated it or even shown lower E2 with subq injection. Doesn't change our observed reality.

Some men feel much better injecting IM, which sometimes correlates with differences in hormone levels like I mentioned above. However, sometimes the numbers are similar on paper, and yet the person still somehow feels better with IM. You might be in that category and will find out when you get your lab results.

The pharmacokinetics should be somewhat (like maybe 20-30%) different between IM and subq, with a lower peak, higher trough, and longer half-life with subq.

I’m one of those in the first example. SC is notably worse than shallow IM for my daily protocol. My free T was actually it in half by using SC and I could tell by every sleepless night something was wrong. My E2 was normal though, so I couldn’t tell what was wrong exactly until I had the blood results. I’ve never had such low-normal free test with perfect e2 before.