estradiol

. History of estrogen: its purification, structure, synthesis, biologic actions and clinical implications. - PubMed - NCBI Clark Sawin Memorial lecture on History of Estrogen delivered at Endo 2018: Player: Clark T Sawin Memorial History of Endocrinology Lecture: Estrogens Over 90 Years...

54 year old male. I'm going to contact Defy, but I'm a little freaked out and wonder if anyone else has been here. I'll try to make it short: I'm on TRT for the second time around. I deal with chronic mental health issues and chronic pain which came about well before low T. First time around I...

You can cut to the ~7minute mark.

Seems like a lot of guys here don’t feel good when HCG is part of their protocol. Then you have people that feel great on it. Do you guys think this is due to E2, or some other factor(s)? Just looking to see what you guys think about it. Thanks.

These are my blood markers - all Labcorp Total Testosterone: 1080 ng/dl Free Testosterone: 19.2 pg/ml Estradiol sensitive: 34.2 pg/ml DHEA : 103 ug/dl IGF-1 : 206 ng/ml I started TRT in April of this year This is what I take Cypionate: 74 mg twice a week (0.37 ml twice a week) . (started with...

I weigh 250lbs @ 5'6, down from 300lbs. At my highest weight had a TT between 250ng/dl and 320ng/dl. I'm now up to 380ng/dl. My SHBG increased as well from 22 to 29. However, I've been noticing my symptoms getting worse as I've lost weight. For one, I'm a more depressed, apathetic and fatigued...

I started TRT using lipo compounded cream in May of this year. at that point my E2 was a little high 32 (> 29) using QuestDiagnostics scale. My endo gave me 1mg anastrozole to take 3 times during the 1st week, and then 1mg once a week. In total, I believe it was 14mg over the course of 4-6...

I've been on trt since early August. Still trying to dial in my protocol. I've just received my latest blood test results and interested to hear thoughts from those on this board. My protocol: 50mg testosterone enanthate every 2 days IM 250iu HCG every other 2 days SQ (so alternate between T...

Hello everybody, I am from France but i will try to do my best so you can understand me. My protocol is : Daily test 16mg HCG 500ui 2times a week And i need an AI but i wonder what is the best option of timing I am lean, i eat clean, and i do cardio and some weight lifting 2 to 3 times a week...

So 2 weeks my e2 bottomed out. Was exhausted as hell no libido the usual. Quit my AI. Move forward two weeks later, I have had sex a couple times with my wife. Libido has been up and down. Like today my exhaustion is high and no libido. Would it be my e2 is now super high? Or am I still...

Hi All, I was on a really bad TRT regimen for many many years (inject 300mg once every 3 weeks). I did not take HCG with my dose either. I was never monitored nor had blood panels. I was taking this dose from 2010 until 2018. I never bothered to get blood panels or check my hematocrit or E2 or...

I keep bumping into data of how Soy Phytoestrogens are good for us, men and women, but the best HRT doc's out there (TOTRoundtable) say the opposite, even the king of HRT Dr John Crisler is against them, so if he is against it there must be something true for sure. To my understanding one of...

Testosterone to oestradiol ratio reflects systemic and plaque inflammation and predicts future cardiovascular events in men with severe atherosclerosis Cardiovascular Research, cvy188, Testosterone to oestradiol ratio reflects systemic and plaque inflammation and predicts future cardiovascular...

Hi all, my endo recently made a statement that I believe to be completely untrue, but I need some "proof". What he said was - "your low E" (pre-TRT and with my initial protocol I had levels that were BELOW what the lab can even measure) "is because you're getting too much test, and that's why...

Hi. My mother started hrt recently (T injections 2x5mg/week. Estradiol patch 3.8mg (replace it every 7 days) and oral progesterone 100mg every day) She is 56 in menopause Her labs on this protocol are T>> 116ng/dl 2 days after injection e2>> 30 pg/ml...

Hi guys, I live in Europe / Switzerland and the docs I've asked have never heard of a "sensitive" Estradiol test. I've read on the forums that over here in Europe, the test doesn't seem to be very common. What should I do in order to manage my Estradiol properly? Are there any rule of thumbs...

So I've always heard that Exemestane has the unique properties of lowering SHBG and raising IGF-1, compared to Anastrozole. I've also heard, that 1 tab of Exemestane (25mg), is basically equivalent to 1 tab of Anastrozole (1mg). I just wanted to post some blood work I had 4 months apart from...

So I just had an interesting thought about E2 levels in men. So the gold standard in regards to where we want our hormones, is to get them to the levels that they were when we were in our prime, correct? So probably around 18-22, I would assume for most men, hormone wise at least. Take total and...

I can't seem to find a definitive correlation to low or high E2, so here is what is going on. The last week or so I've developed really dry skin on my face and scalp. I used to have super dry skin before I started TRT, but after a couple of months on my skin was great, even slightly oily (no...

I am curious how other men feel with high e2 levels... What symptoms and/or negative effects you feel when your estradiol is elevated? I used to be able to run 200+mg doses of testosterone with no AI and be ok when I was like 18-20 year old.. situation changed as I got older I need to be in very...

I started TRT about 10 months ago after attempting every conservative treatment I could try and failing to get results. The honeymoon phase at a conservative dose was amazing, but then I had to switch providers due to my PCP moving. The new providers put me on 200mg once a week with routine...

Hi Guys, I am from the UK and unfortunately do not have the luxury of getting a sensitive estradiol test. The company i use to test my blood is Medichecks and they use chemiluminescence immunoassay testing for estradiol. I know its difficult but can someone give me a sensible estimate of the...

The role of estradiol in male reproductive function. - PubMed - NCBI Abstract Traditionally, testosterone and estrogen have been considered to be male and female sex hormones, respectively. However, estradiol, the predominant form of estrogen, also plays a critical role in male sexual...

Hi, first post here, hoping to find some advice. If this in in the wrong subforum mods please let me know. Anyway I’m a 33 y/o male, 5'10" 195lbs, lifting frequently for 18 month now and by my estimate would be at about 20% body fat, most of which is on my chest and stomach. Haven’t touched...

I won't bore everybody with details and fluff - the numbers speak for themselves. Bottom line, Quest and LabCorp E2 numbers are nowhere near each other based on recent lab work I had done (Quest numbers were 2x LabCorp numbers). Be careful if you are managing E2 with only a single lab...

hi all, i'm kinda new to all this and i've seen plenty of threads on this topic but i just cannot figure out what happened here. i messed up my protocol and ran out of cream, i restarted about 20 days later already feeling pretty crappy. but over the week or so applying the cream things stared...

I started TRT in May this year, working with Defy since there were so many positive recommendations on this forum. At my 90 day consult/labs I saw a significant jump in my T levels (Total T 302 to 1360, Free T 14.7 to 49.9), but also a corresponding jump in my Estradiol (17.5-66.8). I realized...

On another thread i posted, Vince Carter mentioned about also testing free e2. I've never heard about testing that so I'm really curious and trying to educate myself about it. Can one have normal levels of sensitive e2 yet have high free e2? If so, how would one address that problem?

Hello to everyone, I have seen a lot of excellent info on the forum, but I would need some guideance on what to do next. Where do I start: Well, it can be a long story, but I will try to keep it as short as I can. Almost 39 yo, non smoker, 1 or 2 of drinks a week. Started training year and a...

Hi all, First time poster. I'm hoping to get some thoughts on my recent blood tests asap as I have an appointment with my doc tomorrow morning so want to be informed and prepared. Blood test results are attached in photos. I've been on trt 6 weeks, had the bloods done on Monday before HCG, T...

At this point I am just curious, but since we all believe estrogen is important, what does one do if your level is too low? i have a feeling if i lose weight, stop taking dhea, my estradiol will move down to 12 ug/dl or so or maybe even lower. Right now I am 5.4 and 165 lbs, so at least 30...