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Let me explain better what I mean by Puritanism. Henry Mencken defined Puritanism as "the fear that someone, somewhere is having fun." I believe one reason TRT has critics is that some people are uncomfortable with the idea that older men are still sexually active. After all, no one would say...

It's only the abstract. I would like to read the full text on articles like this, but I can't afford to buy pay walled articles. One day I'll figure out how to use SciHub, but it won't help on current articles, which is what I like to discuss.

I often see negative articles and opinions on TRT in the press and social media. The article "Just Another Drug Dealer" is one of the most negative I've seen in a while. The quote they lead the article with sets the tone: “You can dress up greed, but you can’t stop the stench.” It looks like the...

The link to the abstract is through the link in the text abstract. I don't have access to the full text of the article.

A new study tracked men on TRT for five years and tracked cardiovascular events. It found about a 20% increased risk in men on TRT, mostly during the first two years. The abstract says: "Using the UK Clinical Practice Research Datalink (CPRD), we formed a cohort of men aged 45 years or older...

KV Pharmaceutical got the exclusive right to market Makena, a hydroxyprogesterone caproate injection to prevent premature births, and then jacked price from $10 to $1500 a shot. It is now trying to stop compounding pharmacies from making it. The news article says: "By receiving 'orphan drug...

This study is getting a lot of attention in the press today. It used "Mendelian randomization." Basically, some genetic variants cause men to have lower testosterone levels and the study compared the rates of heart disease between men with and without these genetic variations. The study used...

The full article is here. According to research presented at the American Academy of Allergy, Asthma & Immunology Annual Meeting patients with elevated serum testosterone levels were less likely to have current asthma regardless of gender. Data from the 2011-2012 National Health and Nutrition...

Ultra-processed foods are defined as "formulations made mostly or entirely from substances derived from foods and additives with little or any intact foods." When I shop I look at the list of ingredients of products to check if they contain sugars or oils, these I consider processed foods.

About a year ago I gave a talk on healthy aging and one of the points I made was that you shouldn't eat processed foods, because they are engineered by food scientists to make you overeat them. Today I heard about a new study by the NIH that confirms it. A preprint of the study is available, but...

We've seen several of these shortages in medical supplies in recent years and I can only guess why. I believe that the pharmaceutical companies are buying their raw materials from China, just as the underground steroid dealers do, so manufacturing testosterone is a simple procedure. My guess is...

I know nothing about the subject, but got curious and found this article on Google Scholar, a copy/paste from some journal. It's conclusion: In conclusion then AAS seem to have little if any effect on thyroid function per se. The reports by Deyssig & Weissel, and Daly et al suggest the...

The press is reporting that patients are having a difficult time getting testosterone cypionate in South Africa: There is a nationwide stockout in SA of Depo-testosterone. Depo-testosterone is the brand name for testosterone cypionate injections manufactured by pharmaceutical company, Pfizer...

Not all studies mention dose in the abstract.. The two studies that mention dose are, first, a rat study: "10 mg/kg body weight of nandrolone was administered intramuscularly twice a week for 8 weeks. This dose is comparable with a dose frequently used by heavy AAS abusers [1600 mg a week for a...

Here's a bunch of animal studies showing that nandrolone inhibits vasodilation, courtesy of Google Scholar.

The title reflects the title of the Medical Xpress article, "Could higher levels of testosterone hold the key to slower aging?"

A press release from the university that conducted the study was reported by Medical Xpress. Here's a short extract from the article: "A new study of older men carried out by The University of Western Australia has found there is a link between men who have higher levels of the sex hormone...

Cochrane does not do studies, they do meta-analyses using a standard methodology. In this case they based their results on 15 randomized trails. To quote from their report, which you can read online, "We include 15 randomised controlled trials (RCTs) (17 comparisons, ˜59,000 participants)...

I know this is a contentious issue, but the Cochrane Review, the most trusted source on independent medical reviews, has looked at the subject and concluded saturated fat does play a role in heart disease. You can read their review of the studies on saturated fat and heart disease online. Here...

It's been known that men with low testosterone levels are more likely to have caridac problems. However, it has not been clear if there is a causal relationship. Does low testosterone cause cardiac problems or is it only a marker for other health problems associated with cardiac problems, such...

Two journal articles on the therapeutic role testosterone plays in treating type 2 diabetes. Given the increasing prevalence of diabetes and the difficulty most men have making lifestyle changes to mitigate it, I hope we see more doctors prescribing testosterone to their male patients with...

It's unusual to see a study of supraphysiological doses of steroids in men, so this study caught my eye. It shows that boldenone causes kidney damage, but other steroids not so much. The abstract says: BACKGROUND: The aim of this study was to investigate the effect of anabolic steroids on...

Alzheimers was induced in rats by injecting beta amyloid. Testosterone injections protected against mental impairment. The abstract says: Cognitive dysfunction in Alzheimer's disease is strongly associated with a reduction in synaptic plasticity, which may be induced by oxidative stress...

The abstract says it all: The capacity to infer the mental states of others (known as cognitive empathy) is essential for social interactions, and a well-known theory proposes that it is negatively affected by intrauterine testosterone exposure. Furthermore, previous studies reported that...

What's the best tool to use to open an unscored glass ampule?

A study of Medicare records found that men with cardio artery disease (CAD) were more likelt to be on testosterone replacement therapy (TRT) than those who are not. I don't find thiis surprising, as men with low testosterone are more likely to have CAD than men with normal testosterone levels...

This is an interesting idea for a study. Unfortunately, I believe the results are useless because the small dose of testosterone used. The abstract says: "We did a randomised, controlled, open-label trial at four paediatric centres in Finland. Boys aged at least 14 years with CDGP who wanted...

It seems the standard advice on the Internet for increasing your testosterone levels is to do back squats and avoid cardio. A review of the studies showed this advice is questionable for older men. The review concludes: "Data from the present investigation suggests that resistance training does...

A study was performed to assess whetjer exercise improves the strength and endurance of muscles not exercised, in this case the tongue muscle. The study found that this was the case, resistance exercisers had increased tongue muscle strength, while endurance exercisers had increased tongue...

A marker for non-alcoholic fatty liver disease was found to be higher in men with lower testosterone levels, even after controlling for factors of obesity and age. The article says: "We used the highest sex- specific quartiles of serum total testosterone as references. Suspected non- alcoholic...

The study says that participants were recruited from fitness centers or had failed steroid tests for athletic contests. I think it's fair to say all were steroid users, although the study doesn't seem to distinguish dose and substances used by the participants. The purpose of the study was to...