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So I was right, just didn’t have my facts straight. This video at the 10:30 mark talks about how the increase in SERT can further lower already low serotonin levels and lead to panic and increased anxiety in those with certain SERT SNps.

Here is the study https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4585531/ Wait, it seems that I am interpreting this wrong. I’ll find the other one. Results One and 4 months of androgen treatment in female-to-male transsexuals increased SERT binding in amygdala, caudate, putamen, and median...

Totally agree. I also get a bit concerned with the “symptom resolution” approach and “men’s T levels in the 1940’s were 1700 and they all ate meat and banged their wives and every other woman 4 times a day and then fought in the streets and won two wars!” mindset. There is research in Trans...

Oh that is for sure, I have some mild OCD which leads to a near-constant low level anxiety that switches to full anxiety when times get tough. I’m a bit of an odd-bird in regards to most “message board solutions“ where SSRI’s almost completely restore my sexual function for some time and benzos...

Benzos make me feel great, able to do chores, have sex, live life without the judge in my head. However, I only take them in dire situations. I sleep well on them and wake up feeling normal, not drugged. However I sometimes get rebound anxiety from them.

Not yet, been reading a lot of genetic stuff, did my nutrahacker report, and seeing Dr. Rob in a few weeks. I won the genetic lottery, slow COMT, low MAO-a, low GAD which can mean low gaba/high glutamate, and MTHFR!

I get what you’re saying, there are many factors now showing other physical and psychological roadblocks to trt. For example, genetic testing (which I understand is new and not fully proven yet) can show SNPs on GAD1, MAO-A, and COMT that can all react poorly to androgens and can ramp the brain...

Some things to note (So i have my plan documented for my own sake): 1. Genetic testing shows low SERT, Slow COMT (T/T), and low MAOA-A activity - all of these lead to anxiety states, which is my primary issue 2. Taking propecia 20 years ago MAY have lead to decreased allopreg, which is also the...

This is interesting, did you have good results on it? The wife and I are also looking to have kids soon, I’m 40 and I’d like the fertility without the hCG side effects I’ve had in the past.

Since I’m seeing my Dr in a week, I have the following questions on what options would be viable for me. What I know: 1. Clomid did not result in better T, LH and FH did increase, test did not. 2. Cream on body does not absorb, cream on scrotum absorbs too much and DHT goes far to high, also...

Thanks everyone, I’m going to try for 30mg M/Th and no cream. The cream’s initial benefits seem to always turn into the issue later on. I have done just Test Cyp in the past and have been ok. I think my chasing of “perfection” lead me to introduce other variables that simply caused more issues.

I’ve searched the forum for this and haven’t found the exact one you speak of. I wouldn’t say that I have any hardcore Lyme’s issues, but it is hard to tell what it is or isn’t contributing to the big picture. Many of my issues existed pre Lyme’s so I’m at a loss on this aspect of things.

Yes, too high is definitely the case I always run into with scrotal cream solo or added. I do feel like something in it helps, but it always goes haywire with rising levels.

Hi Everyone, Looking for some insight into my seemingly complex issues. Been on TRT for 10+ years in all forms, have seen Crisler, Nichols, Defy. Have had windows of feeling great but then issues always creep in. Background: 1. Took Propecia in college, def caused some issues here and...

Going to have to strongly agree with you here. After years and different approaches (even initial great success on scrotal test cream). I always seemed to lose the honeymoon period and fall into a baseline low. Even though I’m a lowish shbg guy, even 2x shots never did it for me. I just...

I put it on right after showering and drying off, I rub the applicator on to get it started, then use my two fingers to rub it in. Drying time is however long it takes for me to put on deodorant, brush my teeth...so like 5 minutes or so.

I don't recall specific numbers, but I know I'm what is considered a "low-shbg guy". This probably also explains why a daily cream feels better than shots.

I agree with what you are saying. I might try one click twice a day, but I have noticed sleep/mood issues when doing 2x a day dosing. On top of that, it is a real PITA. Once in the morning getting a high peak and then slowly tapering off over the day seems to work best for me. I think that...

I put it on right after I dry off, so the time it takes me to put on deodorant and brush my teeth. As far as the other stuff, it's all fine and dandy.

My random guess is both DHT and short half life. Ultimately I think the short half life is the real big difference though. The supposed theory on the quick peak and drop on cream mimicking natural production seems correct. On shots I'd always feel horrible on injection day, almost like my...

Nothing severe in the atrophy department. Shots seem to cause a much more significant atrophy as I recall. I have not been taking DHEA or Preg. DHEA has always made me angry (not good when you work with children). Preg does have a positive effect for me, but nothing worth staying on it for...

I shave it with a Mach3 and shave gel usually weekly. When I had labs I had not shaved within 5 or so days. Ah the joys of discussing scrotal shaving on the internet lol. But to address your concern, shaving seems to help, but I don't think you have to be on top of it daily.

I am not 100% sure, but I feel like it is their "HRT Base" it seems to be non oily and absorbs within 30 seconds or so.

I think that DHT does play a big role in my success. I took Propecia for about a month in college and that gave me sexual sides. Granted these sides weren't as dramatic as some of the PFS guys have had, but it did something for sure. I put the creme on in the morning when I wake up and...

Yes sir. Same base, same strength, same everything. Only change was putting it (actually less of it) on the scrotum.

No acne issues, and I'm already a hairy sumnabich that has to shave his shoulders and back in the summer. I agree that e2 of 33 seems low with 1500 TT for MOST guys. However I should state that before starting TRT, my e2 senstive test was something like 7.

Well I've been balding since I was 20, so I've shaved my head for 17 years now. Hairloss isn't something I notice since I don't have any lol. Previously I had used the same compounded cream on the typical spots....shoulders, thigh, inner forearms, most of the time not getting above 400 even...

For me, libido and erections have always been more with my brain than my hormones. I tend to have high norepinephrine and things life coffee, stimulants will often kill any chance of an erection. I oddly can take a small dose of an SSRI and get great sexual response from it. I'm not...

I have been on all forms of TRT for over 8 years now. Gels, shots (ranging from e7d, e5d, e3.5d, daily, subq, etc), compounded creams, hcg, no hcg, etc. etc. Nothing seemed to ever really work for me or stick. The last three months I have done T Cream, Empower 200mg and applied 2 clicks every...

Sounds good, and I agree. Going to try: 1. 50mcg t4 2. HCG 500 2x week 3. 25mg DHEA 4. 6 pumps T Gel

I have always been a low e2 guy, so you're point is probably right. As for the midrange t level, this too concerns me. I've done shots before and can easily get into the 1000 range, e2 still around 20 and have zero libido and erections. Gels give me the dht boost and "usually" better...