SERM to Increase SHBG

The slice · Jan 21, 2025

Does anyone have any experience with using a SERM to increase SHBG. I am low single digit and am unable to impact it with frequency changes etc.

I have read that a SERM like Roloxaphine / Clomid / Nolvadex may be effective.

Does anyone have any experience with this as an effective way to treat low SHBG?

Vince · Jan 21, 2025

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Thread 'SHBG Changes after Keto'

Feb 28, 2023

Started the Keto Diet October LY. A1c 6.0, fasted Glucose 128, BP 140/85. 20 lbs over weight. Doc was alarmed with my steady increase in certain blood markers and possible insulin resistance and encouraged me to act.

Fast forward I guess the results are what you would typically expect to see….lost 20lbs. Body fat now 17%, fasted glucose 82, A1c 5.2, BP 115/70. All good things…..the surprise has been the increase in SHBG. Mine has been in the teens since introducing trt. I heard prior to starting the Keto diet that it would raise SHBG and that being the only variable I have changed...

WhiteMale · Jan 21, 2025

The slice said:
Does anyone have any experience with using a SERM to increase SHBG. I am low single digit and am unable to impact it with frequency changes etc.

I have read that a SERM like Roloxaphine / Clomid / Nolvadex may be effective.

Does anyone have any experience with this as an effective way to treat low SHBG?

What concern is it that you have about low SHBG? Nothing raises SHBG in any appreciable way that's going to affect your TRT.

The slice · Jan 21, 2025

WhiteMale said:
What concern is it that you have about low SHBG? Nothing raises SHBG in any appreciable way that's going to affect your TRT.

Libido issues mainly - Unable to feel dialled in after many years of trying.

Systemlord · Jan 21, 2025

The slice said:
Libido issues mainly - Unable to feel dialled in after many years of trying.

That might be just the TRT that doesn’t agree with you. I had the same problem.

WhiteMale · Jan 22, 2025

The slice said:
Libido issues mainly - Unable to feel dialled in after many years of trying.

Would think that your E2 is too high, too high for you vs. what's on the lab report, how you tolerate the E. Best advice I got was have your E2 mirror your SHBG number pretty close. Remember SHBG binds to E as it does with T. You can possibly be assured that while with your SHBG your Free T is high so would Free Estrogen (this can be tested). What is your SHBG?
One of the massive mistakes in TRT is this <=29 for E2 and the mismanagement of low SHBG.

The slice · Jan 22, 2025

WhiteMale said:
Would think that your E2 is too high, too high for you vs. what's on the lab report, how you tolerate the E. Best advice I got was have your E2 mirror your SHBG number pretty close. Remember SHBG binds to E as it does with T. You can possibly be assured that while with your SHBG your Free T is high so would Free Estrogen (this can be tested). What is your SHBG?
One of the massive mistakes in TRT is this <=29 for E2 and the mismanagement of low SHBG.

My SHBG fluctuations between 8 and 11.

It’s interesting you say that, I have considered the idea that my “free” e2 is the problem.

How does one test for free E2?

Cataceous · Jan 23, 2025

The slice said:
...
How does one test for free E2?

If you're US-based and in the right state then you can support the site sponsor:

free estradiol test

This test measures the free (unbound to SHBG or albumin) estradiol in blood. The test is performed using liquid chromatography/mass spectrometry (LC/MS).

www.discountedlabs.com

Alternatively, free estradiol can be estimated with a calculator:

S

Thread 'Spreadsheet for Calculating Free T & E2'

Dec 20, 2018

There's been a lot discussion recently in Excelmale on wanting to test for Free E2 and the relatively high cost of this test. There are online calculators which calculate an estimate of Free T based on Total T, SHBG and Albumin. However there doesn't appear to be an online calculator for estimating Free E2.

I researched the topic and found an article from 2010 by Norman Mazer, Ph.D, who created an Excel spreadsheet for calculating Free T, Free E2, Free DHT and others. The first tab in the spreadsheet is titled "user interface" and you input there the values of Total...

WhiteMale · Jan 23, 2025

While I was working on my own low SHBG and Estrogen levels I was testing Sensitive, LC/MS/MS, regular E2 (the name escapes me) and Estrogen, Free. Where I would have my Sens E2 in my desired range, around 10-15 to mirror my SHBG, but Free Estrogen was over the range. It was an interesting wasy to get a better picture.
I'm very very sensitive to E. Having read on this forum about the E2 and SHBG numbers, then I did a lot of research and just happened to come across a post from Dr Crisler (RIP) where he stated some of his low SHBG guys could tolerate very little Estrogen.
It's not and I'm not perfect but SOOOO much better.