SERM to Increase SHBG

[The slice]

Does anyone have any experience with using a SERM to increase SHBG. I am low single digit and am unable to impact it with frequency changes etc.

I have read that a SERM like Roloxaphine / Clomid / Nolvadex may be effective.

Does anyone have any experience with this as an effective way to treat low SHBG?

 

[Vince]

P

Thread 'SHBG Changes after Keto'

Feb 28, 2023

Started the Keto Diet October LY. A1c 6.0, fasted Glucose 128, BP 140/85. 20 lbs over weight. Doc was alarmed with my steady increase in certain blood markers and possible insulin resistance and encouraged me to act.

Fast forward I guess the results are what you would typically expect to see….lost 20lbs. Body fat now 17%, fasted glucose 82, A1c 5.2, BP 115/70. All good things…..the surprise has been the increase in SHBG. Mine has been in the teens since introducing trt. I heard prior to starting the Keto diet that it would raise SHBG and that being the only variable I have changed...

• Pringle
• keto diet low shbg
• Replies: 34
• Forum: Nutrition and Supplements

• 

 

[WhiteMale]

Does anyone have any experience with using a SERM to increase SHBG. I am low single digit and am unable to impact it with frequency changes etc.

I have read that a SERM like Roloxaphine / Clomid / Nolvadex may be effective.

Does anyone have any experience with this as an effective way to treat low SHBG?

What concern is it that you have about low SHBG? Nothing raises SHBG in any appreciable way that's going to affect your TRT.

 

[The slice]

What concern is it that you have about low SHBG? Nothing raises SHBG in any appreciable way that's going to affect your TRT.

Libido issues mainly - Unable to feel dialled in after many years of trying.

 

[Systemlord]

Libido issues mainly - Unable to feel dialled in after many years of trying.

That might be just the TRT that doesn’t agree with you. I had the same problem.

 

[WhiteMale]

Libido issues mainly - Unable to feel dialled in after many years of trying.

Would think that your E2 is too high, too high for you vs. what's on the lab report, how you tolerate the E. Best advice I got was have your E2 mirror your SHBG number pretty close. Remember SHBG binds to E as it does with T. You can possibly be assured that while with your SHBG your Free T is high so would Free Estrogen (this can be tested). What is your SHBG?
One of the massive mistakes in TRT is this <=29 for E2 and the mismanagement of low SHBG.

 

[The slice]

Would think that your E2 is too high, too high for you vs. what's on the lab report, how you tolerate the E. Best advice I got was have your E2 mirror your SHBG number pretty close. Remember SHBG binds to E as it does with T. You can possibly be assured that while with your SHBG your Free T is high so would Free Estrogen (this can be tested). What is your SHBG?
One of the massive mistakes in TRT is this <=29 for E2 and the mismanagement of low SHBG.

My SHBG fluctuations between 8 and 11.

It’s interesting you say that, I have considered the idea that my “free” e2 is the problem.

How does one test for free E2?