Prolactin - gluten link

[Hisagi]

Been struggling with slightly elevated prolactin, 19 ug/L at last test.

I've had E2 and T both high and low but doesn't affect my PRL. Pituitary is fine too.

I have started to suspect I may have issues with gluten, so I googled gluten and PRL and get this

"wheat product > opioid-like molecules are formed from gluten in the intestinal tract called exorphins > exorphins are taken up by the gut > exorphins bind opioid receptors > prolactin release is stimulated."

I'll be getting a blood screen for celiac next week, I'll also get my hormones and PRL done.

Two days prior to the test I intend to up my gluten intake significantly, really interested to see if there will be any effect on PRL.

 

[jdthoosier]

As one who went through the whole celiac testing process.... The gold standard for detecting celiac is a properly done biopsy. Just because you may have a celiac genetic marker does not mean you are celiac, in fact, a very large chunk of the populace has a celiac marker but far fewer actually have celiac. Genetic markers are probabilistic, not deterministic. Are you seeing someone who has extensive experience with celiac?

 

[Vvs1]

I'd believe in the opioid like molecule. Gluten is extremely hard for people to abstain from eating. Worse than desserts in my opinion.

 

[jdthoosier]

They did put me on a gluten free diet, and recommended mostly dairy free. One thing that clearly occurred as a result of the GF diet is how my allergies and sinus issues improved dramatically. Went from being a regular user of nasal steroids, antihistamines, and Singulair on a regular basis to not needing anything.

 

[Hisagi]

As one who went through the whole celiac testing process.... The gold standard for detecting celiac is a properly done biopsy. Just because you may have a celiac genetic marker does not mean you are celiac, in fact, a very large chunk of the populace has a celiac marker but far fewer actually have celiac. Genetic markers are probabilistic, not deterministic. Are you seeing someone who has extensive experience with celiac?

Haven't had any testing done yet. I recently switched to a breakfast cereal which is 95% wheat. I started experiencing sharp stomach pains and gas. Will see how I go with the tTG-IgA test and take it from there. I doubt I'm a full blown celiac but if gluten is the cause of my elevated PRL I will be pretty excited as I'll actually know what is going on finally.