New Atrevis Hydrogel Based Testosterone Cream from Empower: Surprising Results!

[Nelson Vergel]

After a month of using the new hydrogel cream from Empower Pharmacy at 1 ml per day (4 clicks of 0.25 mg each) my testosterone increased dramatically higher than it was even on 200 mg per week of injectable testosterone cypionate.

and this was after using the cream plus pregnenolone 100 mg nightly.

I was extremely surprised. I did not apply the cream 24 hours before the blood draw.

More on Atrevis Hydrogel

 

[madman]

As of May 1st, 3 weeks in using 4 clicks you were hitting a TT 1352 ng/dL (22 hrs post-application) and very high FT.

2 months later on the same dose (4 clicks), you are hitting a whopping TT 2183 ng/dL (24 hrs post-application) and insanely high FT?

How are you feeling overall regarding mood, energy, libido, erections, sleep?

Did you test hemoglobin/hematocrit?

 

[Nelson Vergel]

How are you feeling overall regarding mood, energy, libido, erections, sleep?

Did you test hemoglobin/hematocrit?

Feeling good, nothing beyond the normal. I was shocked about that T value. My erections have not been strong for a long time but I resort to Levitra if I have to. I have not had libido for a few months but now it is waking up really good.

I wonder why T went up so much more. Is there an effect from taking the pregnenolone? The data I have seen in men not on TRT shows no increase in T with pregnenolone.

Hematocrit sitting at 52.5. I am not going to donate blood. My ferritin is still sitting at 33 even after iron supplementation (with Vit C 1000 mg) for a month before the blood draw.

My cognitive function is definitely better on 100 mg per night of pregnenolone for 3 weeks (no hCG). I am more motivated to finish tasks. I had been in a low mood for the previous 3 months even though life was good. I even stopped participating on ExcelMale. I also started trintellix low dose last week (5 mg qd) since my doctor likes it for low grade depression. That has definitely boosted my mood and libido for sure. Debating now if I should bring back hCG 500 IU twice per week to add it to the pregnenolone and hydrogel testosterone cream. I bet that will make me a little too horned up for my own good.

Still waiting for my progesterone LC/MS results. It takes a while like ultrasensitive estradiol does.

Even after 30 years, I am still learning. The upstream hormone story is getting stronger, I think.

 

[DorianGray]

Nelson, I'm curious about your total iron relative to ferritin. I did a total iron and binding capacity (Quest, Discounted Labs) and found ferritin low (26ng/dL), total iron high (205mcg/dL). So, perhaps there's a concern about additional iron supplementation in your case pushing into an undesireable range?

Regarding the pregnenolone, that is the only thing I added to Dr. recommended TRT supplements and my T/FreeT went up close to but only slightly less than when I was on higher dose T cream. Even after reducing Dhea from 50mg to 25. Went from 3 clicks cream down to 2. Still, I would be reluctant to peg that to pregnenolone without longer term testing.

 

[madman]

Feeling good, nothing beyond the normal. I was shocked about that T value. My erections have not been strong for a long time but I resort to Levitra if I have to. I have not had libido for a few months but now it is waking up really good.

I wonder why T went up so much more. Is there an effect from taking the pregnenolone? The data I have seen in men not on TRT shows no increase in T with pregnenolone.

Hematocrit sitting at 52.5. I am not going to donate blood. My ferritin is still sitting at 33 even after iron supplementation (with Vit C 1000 mg) for a month before the blood draw.

My cognitive function is definitely better on 100 mg per night of pregnenolone for 3 weeks (no hCG). I am more motivated to finish tasks. I had been in a low mood for the previous 3 months even though life was good. I even stopped participating on ExcelMale. I also started trintellix low dose last week (5 mg qd) since my doctor likes it for low grade depression. That has definitely boosted my mood and libido for sure. Debating now if I should bring back hCG 500 IU twice per week to add it to the pregnenolone and hydrogel testosterone cream. I bet that will make me a little too horned up for my own good.

Still waiting for my progesterone LC/MS results. It takes a while like ultrasensitive estradiol does.

Even after 30 years, I am still learning. The upstream hormone story is getting stronger, I think.

Feeling good, nothing beyond the normal. I was shocked about that T value. My erections have not been strong for a long time but I resort to Levitra if I have to. I have not had libido for a few months but now it is waking up really good.

Glad to hear you are feeling good and your libido is kicking in as many on long-term TTh tend to struggle with such.

Hard to believe you are hitting such a high TT/FT from the same dose months later as blood levels would have been stable by the time you had your first set of labs done (May 1).


I wonder why T went up so much more. Is there an effect from taking the pregnenolone? The data I have seen in men not on TRT shows no increase in T with pregnenolone.

Seems odd that your levels would skyrocket on the same dose and I know that there would be no chance of application site/blood drawn to skew the results as you are well aware of such let alone labs were done almost 24 hrs post application!

Oral supplementation with preg will not increase ITT/serum T levels.

Pregnenolone is not even on the World Anti-Doping Agency (WADA) Prohibited List..... mind you DHEA is.

Pregnenolone--->DHEA.

As we know DHEA supplementation has a minimal impact on increasing testosterone in males.


*Pregnenolone is often referred to as the grandparent precursor to the other steroid hormones. Pregnenolone is primarily synthesized from cholesterol in the mitochondria of the adrenal glands. Pregnenolone is also made to a lesser extent in the brain, liver, skin, testes, and ovaries. Once synthesized, pregnenolone may be converted to DHEA (dehydroepiandrosterone) or to progesterone. DHEA serves as a precursor compound to the androgens and the estrogens through androstenedione as the intermediate compound. Progesterone is the precursor to cortisol, aldosterone, androstenedione, estrogen, and testosterone. Pregnenolone has many actions of its own not attributable to its conversion to progesterone or to DHEA. Pregnenolone is important for the function of the brain, nervous tissue, liver, pancreas, reproductive tissues, pituitary, and skin. Pregnenolone is found in higher concentrations in the central nervous system compared to the peripheral tissues which may reflect its importance in brain function. As with many hormones, pregnenolone production declines with age. It is estimated that pregnenolone production is about 60% less at age 75 than at age 35. Pregnenolone levels may also decline under various conditions of physiological stress, such as acute and chronic infections and trauma.


Hematocrit sitting at 52.5. I am not going to donate blood. My ferritin is still sitting at 33 even after iron supplementation (with Vit C 1000 mg) for a month before the blood draw.

Smart move and I would be more concerned with ferritin.

What form of supplemental iron are you currently using and have you tried any others?


My cognitive function is definitely better on 100 mg per night of pregnenolone for 3 weeks (no hCG). I am more motivated to finish tasks. I had been in a low mood for the previous 3 months even though life was good. I even stopped participating on ExcelMale. I also started trintellix low dose last week (5 mg qd) since my doctor likes it for low grade depression. That has definitely boosted my mood and libido for sure. Debating now if I should bring back hCG 500 IU twice per week to add it to the pregnenolone and hydrogel testosterone cream. I bet that will make me a little too horned up for my own good.

At least you are experiencing some improvements with the addition of pregnenolone 3 weeks in let alone you are looking into upping your dose to see if you can achieve optimal levels.

Only time will tell if it enhances your overall well-being.

As we both very well know mood is a powerful driver when it comes to libido.

The main goal when using hCG is to restore physiological ITT levels which are critical when it comes to preserving/maintaining fertility and preventing/minimizing testicular atrophy.


Still waiting for my progesterone LC/MS results. It takes a while like ultrasensitive estradiol does.

Will be interesting to see!


Even after 30 years, I am still learning. The upstream hormone story is getting stronger, I think.

Shut down HPG axis, upstream hormones, the sensitivity of the AR, polymorphism of the AR/CAG repeat length (short/long), SHBG: T binding.

 

[klime]

After a month of using the new hydrogel cream from Empower Pharmacy at 1 ml per day (4 clicks of 0.25 mg each) my testosterone increased dramatically higher than it was even on 200 mg per week of injectable testosterone cypionate.

View attachment 15231


and this was after using the cream plus pregnenolone 100 mg nightly.

View attachment 15232

I was extremely surprised. I did not apply the cream 24 hours before the blood draw.

What brand of pregnenolone are you using ? I need to pick some up.

 

[madman]

@Nelson Vergel

Where does your SHBG sit?

 

[sammmy]

Nelson, are you still applying on testicles? That explains high levels.

 

[madman]

Now, this is getting interesting Nelson?

Testosterone in Atrevis hydrogel base = almost double test levels!

@txmx Empower had not trained all the pharmacist. But as of today, they all will be notified about the Atrevis hydrogel. I have a a friend who is using it on the scrotum and loving it. I am going to start using it on Monday and let you guys know what happens to my T level and libido. I need to...

www.excelmale.com

post #21
Empower had not trained all the pharmacists. But as of today, they all will be notified about the Atrevis hydrogel. I have a friend who is using it on the scrotum and loving it.

I am going to start using it on Monday and let you guys know what happens to my T level and libido. I need to do a baseline Total and Free T and also DHT first. I will stop 50 mg twice per week T injections and hCG as of Thurs.

The script should be faxed to Empower Pharmacy as

Testosterone 200ml/ml cream in Hydrogel base 30ML, Apply 1 ML on scrotum daily. 3 refills


post #28
50 percent on the scrotum and 50 percent on the INNER THIGHS. I feel pretty much the same all day. Libido Is definitely up for the past two weeks since I started. I will see my numbers soon.


post#32 (May 1)
This is after three weeks on the hydrogel testosterone cream. I was off hCG for 8 days before the test. I am decreasing the dose to 3 clicks instead of 4 per day.

TT 1352 ng/dL, FT 380.3 pg/mL

post#77 (June 26)
My results on 1 cc of 200 mg/mL per day (4 clicks) of the Empower hydrogel testosterone cream applied 50% on the scrotum and 50% on the SHOULDERS.

TT 896 ng/dL, FT 197.4

You stayed at the same dose as the previous protocol (4 clicks) in 1st set of labs yet this time around application sites were 50 percent on the scrotum and 50 percent on the inner thighs.

Your TT/FT dropped significantly!




Your most recent labs in this thread:

post #1 (July 2)
After a month of using the new hydrogel cream from Empower Pharmacy at 1 ml per day (4 clicks of 0.25 mg each), my testosterone increased dramatically higher than it was even on 200 mg per week of injectable testosterone cypionate.

TT 2183 ng/dL, FT 571 pg/mL

Again you stayed on the same dose as the previous protocol (4 clicks) in 2nd set of labs but no idea if you kept the application sites the same or as @sammmy stated did you apply 4 clicks strictly scrotal?

Your TT/FT levels went through the roof!

Looking over all 3 sets of labs where the dose was kept the same (4 clicks) but application sites were different.....TT/FT levels were all over the place.

 

[madman]

The million dollar question for the summer of 2021

Did Nelson go full out scrotal?

 

[nicknot]

Nelson, have you looked at your DHT (sorry if I missed it)? The scrotal application is supposed to produce much more DHT due to the presence of a high number of 5a-reductase enzymes.
Any idea where your E2 stands also?

 

[Zibernet]

After a month of using the new hydrogel cream from Empower Pharmacy at 1 ml per day (4 clicks of 0.25 mg each) my testosterone increased dramatically higher than it was even on 200 mg per week of injectable testosterone cypionate.

View attachment 15231


and this was after using the cream plus pregnenolone 100 mg nightly.

View attachment 15232

I was extremely surprised. I did not apply the cream 24 hours before the blood draw.

Might be from high dose Biotin skewing the results.
Are you taking Biotin?

 

[Nelson Vergel]

Are you taking Biotin?

No. Also, this is a test using liquid chromatography- no interactions.

 

[Nelson Vergel]

The million dollar question for the summer of 2021

Did Nelson go full out scrotal?

I used the hydrogel on my scrotum for the first two weeks but switched to shoulders and chest. The itching on my scrotum started driving me crazy.

 

[madman]

I used the hydrogel on my scrotum for the first two weeks but switched to shoulders and chest. The itching on my scrotum started driving me crazy.

Thanks.

Now we know the dose (4 clicks) was kept consistent but different application sites used between all 3 protocols/sets of labs:


Labs/Protocol

(May 1) TT 1352 ng/dL, FT 380.3 pg/mL - 50% on the scrotum and 50% on the INNER THIGHS

(June 6) TT 896 ng/dL, FT 197.4 pg/mL- 50% on the scrotum and 50% on the SHOULDERS

(July 2) TT 2183 ng/dL, FT 571 pg/mL- full scrotal first 2 weeks then 50% on the SHOULDERS and 50% on the CHEST


Your TT/FT level was all over the place let alone absurdly high on the last set of lab's (July 2) non-scrotal applications (50% on the SHOULDERS and 50% on the CHEST).

Odd!

 

[Cooper]

Hi Nelson - maybe I missed it but why did you switch from injection and would you go back or are you happier with cream?

 

[SSHSSA74]

After a month of using the new hydrogel cream from Empower Pharmacy at 1 ml per day (4 clicks of 0.25 mg each) my testosterone increased dramatically higher than it was even on 200 mg per week of injectable testosterone cypionate.

View attachment 15231


and this was after using the cream plus pregnenolone 100 mg nightly.

View attachment 15232

I was extremely surprised. I did not apply the cream 24 hours before the blood draw.

So that is 200 mg of T, correct? I thought you were dropping to 3 clicks, 150 mg.

 

[Nick Thomas]

After a month of using the new hydrogel cream from Empower Pharmacy at 1 ml per day (4 clicks of 0.25 mg each) my testosterone increased dramatically higher than it was even on 200 mg per week of injectable testosterone cypionate.

View attachment 15231


and this was after using the cream plus pregnenolone 100 mg nightly.

View attachment 15232

I was extremely surprised. I did not apply the cream 24 hours before the blood draw.

So that is 200 mg of T, correct? I thought you were dropping to 3 clicks, 150 mg.

Nelson do you know if your PSA went higher. I was on cream and number jumped up from 0.6 to 3.2 eventually went down but got a little worried since fortunately in my 60’s my number stays around 0.6-0.7

 

[Smokey]

Great to hear @

I used the hydrogel on my scrotum for the first two weeks but switched to shoulders and chest. The itching on my scrotum started driving me c

After a month of using the new hydrogel cream from Empower Pharmacy at 1 ml per day (4 clicks of 0.25 mg each) my testosterone increased dramatically higher than it was even on 200 mg per week of injectable testosterone cypionate.

View attachment 15231


and this was after using the cream plus pregnenolone 100 mg nightly.

View attachment 15232

I was extremely surprised. I did not apply the cream 24 hours before the blood draw.

Great to hear. I may switch back to cream but sweating in the summertime seemed like I wasnt absorbing. The one great thing I noticed is that my balls were actually larger than on IM T 200 per week and 500 HCG twice per week.

 

[Nelson Vergel]

Your TT/FT level was all over the place let alone absurdly high on the last set of lab's (July 2) non-scrotal applications (50% on the SHOULDERS and 50% on the CHEST).

Surprising, I know! I have really kept everything the same. There is data that shows transdermals can have high variability in T levels. I think I was able to spread the cream to a larger area when I switched from scrotum/inner thighs to upper body. That may be the reason.