madman
Super Moderator
Treatment of idiopathic oligozoospermia with combined human chorionic gonadotropin/human menopausal gonadotrophin: A randomised, double‐blinded, placebo‐controlled clinical study
Nan Zhao1 | Xi‐Lan Lu2 | Jun‐Tao Li2 | Jian‐Min Zhang
Abstract
To evaluate whether hCG/hMG therapy has beneficial effects on idiopathic oligozoo‐ spermia in Chinese infertility population. The patients were randomly divided into the treatment group receiving hCG/hMG for 3 months and the placebo group receiving placebo for 3 months. Semen and biochemical analysis was performed, and DNA fragmentation as well as spermatid concentration was evaluated. Administration of hCG/ hMG for 3 months could significantly improve sperm concentration, rate of forward motile spermatozoa, total motile sperm count, the percentage of sperm with normal morphology and the rate of spontaneous pregnancy in medium‐ and higher‐level inhibin B group respectively. Moreover, in medium‐ and higher‐level inhibin B group, sperm DNA fragmentation index and spermatid concentration were significantly declined respectively at the end of treatment. However, there were no significant differences in lower‐level inhibin B group before and after treatment in term of seminal parameters, DNA fragmentation and spermatid concentration. HCG/hMG therapy for 3 months has a beneficial effect on a part of male with idiopathic oligozoospermia, and the efficacy of hCG/hMG therapy is associated with the inhibin B level.
In summary, the present experiment shows that combined hCG/hMG therapy for 3 months could result in statistically significant improvements in a part of males with idiopathic oligo‐zoospermia in terms of seminal parameters, DNA fragmentation and spontaneous pregnancy rate, and which may mediated by increased inhibin B secretion and possibly a beneficial effect of on the testes. The efficacy of hCG/hMG therapy is associated with the inhibin B level.
Nan Zhao1 | Xi‐Lan Lu2 | Jun‐Tao Li2 | Jian‐Min Zhang
Abstract
To evaluate whether hCG/hMG therapy has beneficial effects on idiopathic oligozoo‐ spermia in Chinese infertility population. The patients were randomly divided into the treatment group receiving hCG/hMG for 3 months and the placebo group receiving placebo for 3 months. Semen and biochemical analysis was performed, and DNA fragmentation as well as spermatid concentration was evaluated. Administration of hCG/ hMG for 3 months could significantly improve sperm concentration, rate of forward motile spermatozoa, total motile sperm count, the percentage of sperm with normal morphology and the rate of spontaneous pregnancy in medium‐ and higher‐level inhibin B group respectively. Moreover, in medium‐ and higher‐level inhibin B group, sperm DNA fragmentation index and spermatid concentration were significantly declined respectively at the end of treatment. However, there were no significant differences in lower‐level inhibin B group before and after treatment in term of seminal parameters, DNA fragmentation and spermatid concentration. HCG/hMG therapy for 3 months has a beneficial effect on a part of male with idiopathic oligozoospermia, and the efficacy of hCG/hMG therapy is associated with the inhibin B level.
In summary, the present experiment shows that combined hCG/hMG therapy for 3 months could result in statistically significant improvements in a part of males with idiopathic oligo‐zoospermia in terms of seminal parameters, DNA fragmentation and spontaneous pregnancy rate, and which may mediated by increased inhibin B secretion and possibly a beneficial effect of on the testes. The efficacy of hCG/hMG therapy is associated with the inhibin B level.
