Putting non-hypogonadal men on testosterone in order to reverse muscle wasting. The article says:
Eighteen non‐hypogonadal healthy older men, 65–75 years, were assigned in a random double‐blinded fashion to receive, biweekly, either placebo (P, saline, n = 9) or T (Sustanon 250 mg, n = 9) injections over 6 week whole‐body resistance exercise training (RET) (three sets of 8–10 repetitions at 80% one‐repetition maximum).
Testosterone adjuvant to RET augmented total fat‐free mass, legs fat‐free mass, and appendicular fat‐free mass gains while decreasing total fat mass. Augmentations in VL muscle thickness, fascicle length, and quadriceps cross‐section area with RET occured to a greater extent in T. Sum strength and maximal voluntary contract (e.g. knee extension at 70°) increased significantly more in the T group. Mechanistically, both muscle protein synthesis rates and absolute breakdown rates were elevated with T therapy, which led to higher net turnover and protein accretion in the T group. Increases in ribosomal biogenesis (RNA
NA ratio); mRNA expression relating to T metabolism; insulin‐like growth factor (IGF)‐1 signalling and myogenic regulatory factors; and the activity of anabolic signalling (e.g. mTOR, AKT, and RPS6) were all up‐regulated with T therapy. Only T up‐regulated mitochondrial citrate synthase activity and transcription factor A, in addition to peroxisome proliferator‐activated receptor‐γ co‐activator 1‐α mRNA.
Administration of T adjuvant to RET enhanced skeletal muscle mass and performance, while up‐regulating myogenic gene programming, myocellular translational efficiency and capacity, collectively resulting in higher protein turnover, and net protein accretion. T coupled with RET is an effective short‐term intervention to improve muscle mass/function in older non‐hypogonadal men.
Eighteen non‐hypogonadal healthy older men, 65–75 years, were assigned in a random double‐blinded fashion to receive, biweekly, either placebo (P, saline, n = 9) or T (Sustanon 250 mg, n = 9) injections over 6 week whole‐body resistance exercise training (RET) (three sets of 8–10 repetitions at 80% one‐repetition maximum).
Testosterone adjuvant to RET augmented total fat‐free mass, legs fat‐free mass, and appendicular fat‐free mass gains while decreasing total fat mass. Augmentations in VL muscle thickness, fascicle length, and quadriceps cross‐section area with RET occured to a greater extent in T. Sum strength and maximal voluntary contract (e.g. knee extension at 70°) increased significantly more in the T group. Mechanistically, both muscle protein synthesis rates and absolute breakdown rates were elevated with T therapy, which led to higher net turnover and protein accretion in the T group. Increases in ribosomal biogenesis (RNA
NA ratio); mRNA expression relating to T metabolism; insulin‐like growth factor (IGF)‐1 signalling and myogenic regulatory factors; and the activity of anabolic signalling (e.g. mTOR, AKT, and RPS6) were all up‐regulated with T therapy. Only T up‐regulated mitochondrial citrate synthase activity and transcription factor A, in addition to peroxisome proliferator‐activated receptor‐γ co‐activator 1‐α mRNA. Administration of T adjuvant to RET enhanced skeletal muscle mass and performance, while up‐regulating myogenic gene programming, myocellular translational efficiency and capacity, collectively resulting in higher protein turnover, and net protein accretion. T coupled with RET is an effective short‐term intervention to improve muscle mass/function in older non‐hypogonadal men.
