Supraphysiologic testosterone (350 mg weekly)

Polynaeu

New Member
"Conclusion

While 10–12 weeks of supraphysiologic testosterone reliably suppresses endogenous LH, FSH, and testosterone secretion, current high‑quality trials demonstrate full recovery of hormone levels within 3–6 months in healthy men, with no permanent disruption observed in these controlled settings . Healthy individuals considering short-term high‑dose testosterone should anticipate temporary axis suppression but can expect eventual biochemical normalization without long‑term endocrine harm."

I'm 30 years old. My total testosterone is in the 400s, and my free testosterone is 15.11 pg/ml (range: 6.7–50). I have low libido, and while I don’t feel overwhelmingly tired, I often lack energy. I suspect this might be more related to depression. I’ve tried several antidepressants, but none have really helped with my motivation issues.

I'm curious how higher testosterone levels might affect my mental state, and I’m also looking to build more muscle mass. I’m planning a 12-week trial where I’ll be using Sustanon 250 mg every five days, along with regular blood tests every three weeks.

When I asked an AI about it, the response I got suggested that a short-term increase in testosterone likely wouldn’t cause serious problems, according to scientific studies.

Does that sound accurate? I’ve done quite a bit of research, and there’s a lot of helpful information here, so I thought this would be a good place to ask.

Also, just to add — I've done a short trial before. I used high testosterone for about a month, and my libido shot up. But it wasn’t consistent — I only felt a noticeable boost two or three times. I ended up stopping because I got nervous about the side effects.
 
"Conclusion

While 10–12 weeks of supraphysiologic testosterone reliably suppresses endogenous LH, FSH, and testosterone secretion, current high‑quality trials demonstrate full recovery of hormone levels within 3–6 months in healthy men, with no permanent disruption observed in these controlled settings . Healthy individuals considering short-term high‑dose testosterone should anticipate temporary axis suppression but can expect eventual biochemical normalization without long‑term endocrine harm."

I'm 30 years old. My total testosterone is in the 400s, and my free testosterone is 15.11 pg/ml (range: 6.7–50). I have low libido, and while I don’t feel overwhelmingly tired, I often lack energy. I suspect this might be more related to depression. I’ve tried several antidepressants, but none have really helped with my motivation issues.

I'm curious how higher testosterone levels might affect my mental state, and I’m also looking to build more muscle mass. I’m planning a 12-week trial where I’ll be using Sustanon 250 mg every five days, along with regular blood tests every three weeks.

When I asked an AI about it, the response I got suggested that a short-term increase in testosterone likely wouldn’t cause serious problems, according to scientific studies.

Does that sound accurate? I’ve done quite a bit of research, and there’s a lot of helpful information here, so I thought this would be a good place to ask.

Also, just to add — I've done a short trial before. I used high testosterone for about a month, and my libido shot up. But it wasn’t consistent — I only felt a noticeable boost two or three times. I ended up stopping because I got nervous about the side effects.
Why do you have low testosterone? What levels are your LH and FSH?
 
I agree with Vince that looking into things like chronic infection or gut micro-biome issues, both of which could cause your symptoms, is a good place to start.

The issue with recovering your production is that 1) something that works for most people may occur for you, and more importantly 2) even if your production recovers, you body is a finely tuned machine of feedback loops and having higher testosterone for a while can impact dopamine pathways and other things that may not reset. DHEA, PT-141 making sure you're not overtraining or under eating, are some other things you may want to try first.
 
"Conclusion

While 10–12 weeks of supraphysiologic testosterone reliably suppresses endogenous LH, FSH, and testosterone secretion, current high‑quality trials demonstrate full recovery of hormone levels within 3–6 months in healthy men, with no permanent disruption observed in these controlled settings . Healthy individuals considering short-term high‑dose testosterone should anticipate temporary axis suppression but can expect eventual biochemical normalization without long‑term endocrine harm."

I'm 30 years old. My total testosterone is in the 400s, and my free testosterone is 15.11 pg/ml (range: 6.7–50). I have low libido, and while I don’t feel overwhelmingly tired, I often lack energy. I suspect this might be more related to depression. I’ve tried several antidepressants, but none have really helped with my motivation issues.

I'm curious how higher testosterone levels might affect my mental state, and I’m also looking to build more muscle mass. I’m planning a 12-week trial where I’ll be using Sustanon 250 mg every five days, along with regular blood tests every three weeks.

When I asked an AI about it, the response I got suggested that a short-term increase in testosterone likely wouldn’t cause serious problems, according to scientific studies.

Does that sound accurate? I’ve done quite a bit of research, and there’s a lot of helpful information here, so I thought this would be a good place to ask.

Also, just to add — I've done a short trial before. I used high testosterone for about a month, and my libido shot up. But it wasn’t consistent — I only felt a noticeable boost two or three times. I ended up stopping because I got nervous about the side effects.

Just to be clear this is a men's health/HRT forum and we are not here to dish out advice when it comes to cycling T let alone use/abuse of any AAS for the sole purpose of enhancing muscle/strength.

We are using therapeutic doses of T (100-200 mg T/week) here to treat symtoms of hypogonadism.

350 mg T week has absolutely nothing to do with hormone replacement therapy.

You will be far better off searching the numerous steroid forums littered on the net.

If you are strictly interested in addressing anything related to hormone replacement, nutrition/supplements, training, overall health then Nelsons Excel is where it's at!
 

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