I'm a Defy patient and waiting for my appointment with Dr. Saya in a month or so. I'm feeling pretty bad and hoping to get some suggestions and answers from the community here or maybe from Dr. Saya if he's around and sees this.
I've been on TRT for over 2 years now, with Defy for around 10 months. I'm 38, 6' tall, 195 pounds and in very good shape. Not sure on body fat % but I have a flat stomach, no love handles, and visible abs when I flex. No other health problems, work out 5x/week.
I've kept a log of everything related to my TRT treatments. Here is some history of my dosages, lab results, and how I felt.
9-21-15 After 4 weeks on 100mg Test 2x/week, 100 IU HCG/day, 0.25mg Anastrozole 2x/week:
Total T: 1237
Free T: 43.8
Estradiol: 20 on injection day, 24 the next day.
Notes: This is from a while back with another doctor, before I started with Defy. I'm including it because this is the best I've felt. I still had occasional issues and certain days of the week seemed better than others, which is why my doc and I kept tweaking things.
6-30-16 After 4 weeks on 56mg Test EOD, 125 IU HCG every day, 0.1mg Anastrozole every other day:
Total T: 1266-1438 (trough and peak)
Free T: 32 - 32.6
Estradiol: 16.3 - 33.5 (big swing from one day to the next!)
Felt pretty good, still some brain fog and ED. Needed 10mg of Cialis/day to function when I used to only need 5mg/day. Still noticing that I feel much better on some days than others, even with EOD injections.
In an attempt to get more stable E2 levels day to day, my anastrozole was switched from 0.1mg every other day to 0.05 every day. The results can be seen below. In a nutshell, I felt much worse and got very bad ED, even with Cialis.
8-22-16: After 4 weeks on 56mg Test EOD, 125 HCG every day, 0.05 mg Anastrozole every day (0.05, NOT 0.5)
Total T: 1291-1350
Free T: 27.9-28.6
Estradiol: 28.6 in morning before T injection, 30.1 same day, 6 hours later, after taking T and Anastrozole, 35.5 next morning (before taking Anastrozole).
Result: Feel bad. Brain fog, forgetful, bad mood, bad ED even on 10mg Cialis/day. I feel and function noticeably better (still not great) from 8-30 hours after taking my T shot, then go downhill again until it's time for the next one.
so...
Should I have a good mood and good erectile function at TT: 1291-1353, FT: 27.9-28.6, and E2: 28.3-35.3 ? Is an E2 level around 35 enough to cause symptoms with total T so high, or should I be looking at other possibilities?
While my total testosterone was always between 1200-1400 at the time of my labs, my Free Testosterone dropped from 43.8, to 32, to 28 as time went on - all at the same Total T levels. Any ideas why this would happen? The main changes in my routine seem to be splitting testosterone and anastrozole doses up into smaller, more frequent doses which somewhat correspond to the drop in free T to total T ratio. Are either of these things that might affect free T? What else might affect it? It's a pretty significant drop and I'm wondering if my free T level is why I'm feeling worse now.
At this point, at TT: 1291-1353, FT: 27.9-28.6, and E2: 28.3-35.3 I'm still having problems. Where should I go from here? Is the problem likely my lower free T level, or my E2 level of around 35? Which should I focus on?
Any advice would be appreciated.
I've been on TRT for over 2 years now, with Defy for around 10 months. I'm 38, 6' tall, 195 pounds and in very good shape. Not sure on body fat % but I have a flat stomach, no love handles, and visible abs when I flex. No other health problems, work out 5x/week.
I've kept a log of everything related to my TRT treatments. Here is some history of my dosages, lab results, and how I felt.
9-21-15 After 4 weeks on 100mg Test 2x/week, 100 IU HCG/day, 0.25mg Anastrozole 2x/week:
Total T: 1237
Free T: 43.8
Estradiol: 20 on injection day, 24 the next day.
Notes: This is from a while back with another doctor, before I started with Defy. I'm including it because this is the best I've felt. I still had occasional issues and certain days of the week seemed better than others, which is why my doc and I kept tweaking things.
6-30-16 After 4 weeks on 56mg Test EOD, 125 IU HCG every day, 0.1mg Anastrozole every other day:
Total T: 1266-1438 (trough and peak)
Free T: 32 - 32.6
Estradiol: 16.3 - 33.5 (big swing from one day to the next!)
Felt pretty good, still some brain fog and ED. Needed 10mg of Cialis/day to function when I used to only need 5mg/day. Still noticing that I feel much better on some days than others, even with EOD injections.
In an attempt to get more stable E2 levels day to day, my anastrozole was switched from 0.1mg every other day to 0.05 every day. The results can be seen below. In a nutshell, I felt much worse and got very bad ED, even with Cialis.
8-22-16: After 4 weeks on 56mg Test EOD, 125 HCG every day, 0.05 mg Anastrozole every day (0.05, NOT 0.5)
Total T: 1291-1350
Free T: 27.9-28.6
Estradiol: 28.6 in morning before T injection, 30.1 same day, 6 hours later, after taking T and Anastrozole, 35.5 next morning (before taking Anastrozole).
Result: Feel bad. Brain fog, forgetful, bad mood, bad ED even on 10mg Cialis/day. I feel and function noticeably better (still not great) from 8-30 hours after taking my T shot, then go downhill again until it's time for the next one.
so...
Should I have a good mood and good erectile function at TT: 1291-1353, FT: 27.9-28.6, and E2: 28.3-35.3 ? Is an E2 level around 35 enough to cause symptoms with total T so high, or should I be looking at other possibilities?
While my total testosterone was always between 1200-1400 at the time of my labs, my Free Testosterone dropped from 43.8, to 32, to 28 as time went on - all at the same Total T levels. Any ideas why this would happen? The main changes in my routine seem to be splitting testosterone and anastrozole doses up into smaller, more frequent doses which somewhat correspond to the drop in free T to total T ratio. Are either of these things that might affect free T? What else might affect it? It's a pretty significant drop and I'm wondering if my free T level is why I'm feeling worse now.
At this point, at TT: 1291-1353, FT: 27.9-28.6, and E2: 28.3-35.3 I'm still having problems. Where should I go from here? Is the problem likely my lower free T level, or my E2 level of around 35? Which should I focus on?
Any advice would be appreciated.